ID A0A1S3FVC7_DIPOR Unreviewed; 419 AA.
AC A0A1S3FVC7;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 28-JAN-2026, entry version 41.
DE RecName: Full=Vascular endothelial growth factor C {ECO:0000256|ARBA:ARBA00070957};
DE AltName: Full=Flt4 ligand {ECO:0000256|ARBA:ARBA00080219};
DE AltName: Full=Vascular endothelial growth factor-related protein {ECO:0000256|ARBA:ARBA00082345};
GN Name=Vegfc {ECO:0000313|RefSeq:XP_012879974.1};
OS Dipodomys ordii (Ord's kangaroo rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Castorimorpha; Heteromyidae;
OC Dipodomyinae; Dipodomys.
OX NCBI_TaxID=10020 {ECO:0000313|Proteomes:UP000081671, ECO:0000313|RefSeq:XP_012879974.1};
RN [1] {ECO:0000313|RefSeq:XP_012879974.1}
RP IDENTIFICATION.
RC TISSUE=Kidney {ECO:0000313|RefSeq:XP_012879974.1};
RG RefSeq;
RL Submitted (AUG-2025) to UniProtKB.
CC -!- FUNCTION: Growth factor active in angiogenesis, and endothelial cell
CC growth, stimulating their proliferation and migration and also has
CC effects on the permeability of blood vessels. May function in
CC angiogenesis of the venous and lymphatic vascular systems during
CC embryogenesis, and also in the maintenance of differentiated lymphatic
CC endothelium in adults. Binds and activates KDR/VEGFR2 and FLT4/VEGFR3
CC receptors. {ECO:0000256|ARBA:ARBA00055409}.
CC -!- SUBUNIT: Homodimer; non-covalent and antiparallel. Interacts with
CC FLT4/VEGFR3; the interaction is required for FLT4/VEGFR3
CC homodimarization and activation. {ECO:0000256|ARBA:ARBA00063227}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the PDGF/VEGF growth factor family.
CC {ECO:0000256|ARBA:ARBA00006686, ECO:0000256|RuleBase:RU003818}.
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DR RefSeq; XP_012879974.1; XM_013024520.1.
DR AlphaFoldDB; A0A1S3FVC7; -.
DR FunCoup; A0A1S3FVC7; 1072.
DR STRING; 10020.ENSDORP00000018857; -.
DR GeneID; 105991790; -.
DR KEGG; dord:105991790; -.
DR CTD; 7424; -.
DR InParanoid; A0A1S3FVC7; -.
DR OMA; ALPQCQA; -.
DR OrthoDB; 9981160at2759; -.
DR Proteomes; UP000081671; Unplaced.
DR GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0042056; F:chemoattractant activity; IEA:Ensembl.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0043185; F:vascular endothelial growth factor receptor 3 binding; IEA:Ensembl.
DR GO; GO:0009887; P:animal organ morphogenesis; IEA:Ensembl.
DR GO; GO:1990830; P:cellular response to leukemia inhibitory factor; IEA:Ensembl.
DR GO; GO:0014009; P:glial cell proliferation; IEA:Ensembl.
DR GO; GO:0050930; P:induction of positive chemotaxis; IEA:Ensembl.
DR GO; GO:0016331; P:morphogenesis of embryonic epithelium; IEA:Ensembl.
DR GO; GO:0045668; P:negative regulation of osteoblast differentiation; IEA:Ensembl.
DR GO; GO:0045766; P:positive regulation of angiogenesis; IEA:Ensembl.
DR GO; GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-KW.
DR GO; GO:0001938; P:positive regulation of endothelial cell proliferation; IEA:TreeGrafter.
DR GO; GO:0060252; P:positive regulation of glial cell proliferation; IEA:Ensembl.
DR GO; GO:1901492; P:positive regulation of lymphangiogenesis; IEA:Ensembl.
DR GO; GO:0060754; P:positive regulation of mast cell chemotaxis; IEA:Ensembl.
DR GO; GO:1902462; P:positive regulation of mesenchymal stem cell proliferation; IEA:Ensembl.
DR GO; GO:0001666; P:response to hypoxia; IEA:TreeGrafter.
DR GO; GO:0002040; P:sprouting angiogenesis; IEA:TreeGrafter.
DR GO; GO:0048010; P:vascular endothelial growth factor receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0038084; P:vascular endothelial growth factor signaling pathway; IEA:TreeGrafter.
DR CDD; cd00135; PDGF; 1.
DR FunFam; 2.10.90.10:FF:000025; vascular endothelial growth factor C; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR004153; CXCXC_repeat.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR023581; PD_growth_factor_CS.
DR InterPro; IPR000072; PDGF/VEGF_dom.
DR InterPro; IPR050507; PDGF/VEGF_growth_factor.
DR PANTHER; PTHR12025; VASCULAR ENDOTHELIAL GROWTH FACTOR; 1.
DR PANTHER; PTHR12025:SF3; VASCULAR ENDOTHELIAL GROWTH FACTOR C; 1.
DR Pfam; PF03128; CXCXC; 3.
DR Pfam; PF00341; PDGF; 1.
DR SMART; SM00141; PDGF; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00249; PDGF_1; 1.
DR PROSITE; PS50278; PDGF_2; 1.
PE 3: Inferred from homology;
KW Angiogenesis {ECO:0000256|ARBA:ARBA00022657};
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|RuleBase:RU003818}; Mitogen {ECO:0000256|ARBA:ARBA00023246};
KW Reference proteome {ECO:0000313|Proteomes:UP000081671};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..419
FT /note="Vascular endothelial growth factor C"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010291674"
FT DOMAIN 117..216
FT /note="Platelet-derived growth factor (PDGF) family
FT profile"
FT /evidence="ECO:0000259|PROSITE:PS50278"
SQ SEQUENCE 419 AA; 46886 MW; 74F870109DF8E8D0 CRC64;
MHLLGFLSLA CSLLAAALLP GPRQAPAAAA AWESGLGYSD AEPDAGEVKA YASKDLEGQL
RSVSSVDELM TVLYPEYWKM YKCQLRKGGW QHNKEQANPN TRTEDTVTFA AAHYNAEILK
SIDNEWRKTQ CMPREVCIDV GKEFGAATNT FFKPPCVSVY RCGGCCNSEG LQCMNTSTGY
LSKTLFEITV PLSQGPKPVT VSFANHTSCR CMSKLDVYRQ VHSIIRRSLP ATLPQCQAAN
KTCPMNYIWN NHLCRCLAQQ DFMFSSNTED DTTNGFHDIC GPNKELDEET CQCVCKGGLR
ASSCGPHKEL DRDSCQCVCK NKLFPNSCGA NREFDENTCQ CVCKRTCPRN QPLNPGKCTC
ECTENPQKCF LKGKKFQHQT CSCYRRPCTN RMKHCEPGLS FSEEVCRCVP SYWKRPHMN
//
