ID A0A1S3MRH2_SALSA Unreviewed; 178 AA.
AC A0A1S3MRH2;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 28-JAN-2026, entry version 35.
DE SubName: Full=Glucagon-1 {ECO:0000313|RefSeq:XP_014005828.1};
GN Name=LOC106574454 {ECO:0000313|RefSeq:XP_014005828.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP001652741, ECO:0000313|RefSeq:XP_014005828.1};
RN [1] {ECO:0000313|RefSeq:XP_014005828.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (AUG-2025) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the glucagon family.
CC {ECO:0000256|ARBA:ARBA00008369}.
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DR RefSeq; XP_014005828.1; XM_014150353.2.
DR AlphaFoldDB; A0A1S3MRH2; -.
DR STRING; 8030.ENSSSAP00000111976; -.
DR PaxDb; 8030-ENSSSAP00000111976; -.
DR GeneID; 106574454; -.
DR KEGG; sasa:106574454; -.
DR OMA; WVMTSKT; -.
DR OrthoDB; 9904258at2759; -.
DR Proteomes; UP001652741; Chromosome ssa16.
DR Bgee; ENSSSAG00000078604; Expressed in hindgut and 9 other cell types or tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0031769; F:glucagon receptor binding; IEA:TreeGrafter.
DR GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR GO; GO:0042594; P:response to starvation; IEA:TreeGrafter.
DR Gene3D; 6.10.250.590; -; 3.
DR InterPro; IPR015550; Glucagon.
DR InterPro; IPR000532; Glucagon_GIP_secretin_VIP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR PANTHER; PTHR11418; GLUCAGON; 1.
DR PANTHER; PTHR11418:SF0; PRO-GLUCAGON; 1.
DR Pfam; PF00123; Hormone_2; 2.
DR SMART; SM00070; GLUCA; 3.
DR PROSITE; PS00260; GLUCAGON; 3.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP001652741};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..178
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010270128"
FT DOMAIN 52..74
FT /note="Glucagon / GIP / secretin / VIP family"
FT /evidence="ECO:0000259|PROSITE:PS00260"
FT DOMAIN 90..112
FT /note="Glucagon / GIP / secretin / VIP family"
FT /evidence="ECO:0000259|PROSITE:PS00260"
FT DOMAIN 137..159
FT /note="Glucagon / GIP / secretin / VIP family"
FT /evidence="ECO:0000259|PROSITE:PS00260"
SQ SEQUENCE 178 AA; 20068 MW; 3DF5DB6E1588F77A CRC64;
MFGIHSLAGV LLLVIVQSSW QVPLQEAEDN SSLETADPLL EDLMGVSNMK RHSEGTFSND
YSKYQEERMA QDFVQWLMNS KRSGAPSKRH ADGTYTSDVS TYLQDQAAKD FVSWLKSGRA
RRESAEESRN GPMSRRHVDG SFTSDVNKVL DSLAAKEYLL WVMTSKTSGK SNKRQEDH
//
