ID A0A1S3P2Q6_SALSA Unreviewed; 184 AA.
AC A0A1S3P2Q6;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 28-JAN-2026, entry version 38.
DE SubName: Full=Transcription factor HES-5-like {ECO:0000313|RefSeq:XP_014021821.1};
GN Name=LOC106582843 {ECO:0000313|RefSeq:XP_014021821.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP001652741, ECO:0000313|RefSeq:XP_014021821.1};
RN [1] {ECO:0000313|RefSeq:XP_014021821.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (AUG-2025) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR RefSeq; XP_014021821.1; XM_014166346.1.
DR AlphaFoldDB; A0A1S3P2Q6; -.
DR PaxDb; 8030-ENSSSAP00000108525; -.
DR GeneID; 106582843; -.
DR KEGG; sasa:106582843; -.
DR OrthoDB; 6085656at2759; -.
DR Proteomes; UP001652741; Chromosome ssa22.
DR Bgee; ENSSSAG00000077365; Expressed in sexually immature organism and 2 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd11461; bHLH-O_HES5; 1.
DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR050370; HES_HEY.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR003650; Orange_dom.
DR PANTHER; PTHR10985; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, HES-RELATED; 1.
DR Pfam; PF07527; Hairy_orange; 1.
DR Pfam; PF00010; HLH; 1.
DR SMART; SM00353; HLH; 1.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR SUPFAM; SSF158457; Orange domain-like; 1.
DR PROSITE; PS50888; BHLH; 1.
DR PROSITE; PS51054; ORANGE; 1.
PE 4: Predicted;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP001652741};
KW Repressor {ECO:0000256|ARBA:ARBA00022491};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 39..95
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT DOMAIN 112..142
FT /note="Orange"
FT /evidence="ECO:0000259|PROSITE:PS51054"
FT REGION 142..172
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 184 AA; 21373 MW; DC0DFEE5029C5C9A CRC64;
MKPVEIRFSL HRPLQHRDPA MVPTITSAMI YSKEHLTLTN KLRKPVVEKL RRDRINNSIE
QLKSLLVPEI LNQQPDSKLD KADILEMTVC ILRQQQQNQS VSSSFCSAPV NQGYSRCVQE
IVHFLSKDEL TTQSQRRLLS HFQSLQPSSE KNRREIDRPQ LSSPAQHSIS KDRSPVNITL
WRPW
//
