ID A0A1S3SDU4_SALSA Unreviewed; 3326 AA.
AC A0A1S3SDU4;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 08-OCT-2025, sequence version 2.
DT 28-JAN-2026, entry version 49.
DE SubName: Full=Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 isoform X3 {ECO:0000313|RefSeq:XP_014062515.2};
GN Name=LOC106608858 {ECO:0000313|RefSeq:XP_014062515.2};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP001652741, ECO:0000313|RefSeq:XP_014062515.2};
RN [1] {ECO:0000313|RefSeq:XP_014062515.2}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (AUG-2025) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR RefSeq; XP_014062515.2; XM_014207040.2.
DR GeneID; 106608858; -.
DR Proteomes; UP001652741; Chromosome ssa07.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005178; F:integrin binding; IEA:UniProtKB-ARBA.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0003013; P:circulatory system process; IEA:UniProtKB-ARBA.
DR GO; GO:0030855; P:epithelial cell differentiation; IEA:UniProtKB-ARBA.
DR GO; GO:0051241; P:negative regulation of multicellular organismal process; IEA:UniProtKB-ARBA.
DR GO; GO:0010572; P:positive regulation of platelet activation; IEA:UniProtKB-ARBA.
DR GO; GO:0048731; P:system development; IEA:UniProtKB-ARBA.
DR CDD; cd00033; CCP; 34.
DR CDD; cd00054; EGF_CA; 7.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 2.10.70.10; Complement Module, domain 1; 35.
DR Gene3D; 2.10.25.10; Laminin; 10.
DR Gene3D; 2.10.50.10; Tumor Necrosis Factor Receptor, subunit A, domain 2; 3.
DR InterPro; IPR050350; Compl-Cell_Adhes-Reg.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR000742; EGF.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR003410; HYR_dom.
DR InterPro; IPR049883; NOTCH1_EGF-like.
DR InterPro; IPR001759; PTX_dom.
DR InterPro; IPR035976; Sushi/SCR/CCP_sf.
DR InterPro; IPR000436; Sushi_SCR_CCP_dom.
DR InterPro; IPR011641; Tyr-kin_ephrin_A/B_rcpt-like.
DR PANTHER; PTHR19325; COMPLEMENT COMPONENT-RELATED SUSHI DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR19325:SF575; LOCOMOTION-RELATED PROTEIN HIKARU GENKI; 1.
DR Pfam; PF00008; EGF; 5.
DR Pfam; PF07645; EGF_CA; 1.
DR Pfam; PF07699; Ephrin_rec_like; 4.
DR Pfam; PF12661; hEGF; 3.
DR Pfam; PF02494; HYR; 2.
DR Pfam; PF00354; Pentaxin; 1.
DR Pfam; PF00084; Sushi; 34.
DR PRINTS; PR00895; PENTAXIN.
DR SMART; SM00032; CCP; 35.
DR SMART; SM00181; EGF; 13.
DR SMART; SM00179; EGF_CA; 8.
DR SMART; SM01411; Ephrin_rec_like; 4.
DR SMART; SM00159; PTX; 1.
DR SUPFAM; SSF57535; Complement control module/SCR domain; 35.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 3.
DR PROSITE; PS00010; ASX_HYDROXYL; 6.
DR PROSITE; PS00022; EGF_1; 8.
DR PROSITE; PS01186; EGF_2; 9.
DR PROSITE; PS50026; EGF_3; 9.
DR PROSITE; PS01187; EGF_CA; 3.
DR PROSITE; PS50825; HYR; 2.
DR PROSITE; PS51828; PTX_2; 1.
DR PROSITE; PS50923; SUSHI; 35.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP001652741};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Sushi {ECO:0000256|ARBA:ARBA00022659, ECO:0000256|PROSITE-
KW ProRule:PRU00302}.
FT DOMAIN 64..123
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 124..183
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 184..248
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 247..331
FT /note="HYR"
FT /evidence="ECO:0000259|PROSITE:PS50825"
FT DOMAIN 332..411
FT /note="HYR"
FT /evidence="ECO:0000259|PROSITE:PS50825"
FT DOMAIN 412..475
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 890..926
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 928..964
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 966..1002
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1004..1040
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1042..1078
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1080..1116
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1121..1323
FT /note="Pentraxin (PTX)"
FT /evidence="ECO:0000259|PROSITE:PS51828"
FT DOMAIN 1325..1383
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 1384..1441
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 1441..1480
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1483..1540
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 1541..1598
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 1599..1656
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 1657..1714
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 1715..1776
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 1777..1839
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 1840..1897
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 1898..1957
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 1958..2016
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2017..2074
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2075..2136
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2137..2194
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2195..2252
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2253..2309
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2310..2398
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2399..2456
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2457..2514
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2515..2572
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2573..2632
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2633..2690
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2691..2747
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2748..2807
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2808..2866
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2867..2928
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2929..2986
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2987..3044
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 3046..3103
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 3104..3165
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 3166..3222
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 3252..3284
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 3285..3316
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 578..602
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 578..595
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 94..121
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 154..181
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 916..925
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 954..963
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 992..1001
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1030..1039
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1068..1077
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1106..1115
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1354..1381
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 1412..1439
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 1511..1538
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 1569..1596
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 1627..1654
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 1685..1712
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 1779..1822
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 1868..1895
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 2045..2072
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 2107..2134
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 2165..2192
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 2223..2250
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 2369..2396
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 2427..2454
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 2485..2512
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 2543..2570
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 2661..2688
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 2718..2745
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 2957..2984
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 3015..3042
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 3074..3101
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 3136..3163
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 3256..3266
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 3274..3283
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 3288..3298
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 3306..3315
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 3326 AA; 359263 MW; DF1AC10F58BF5948 CRC64;
MLMDRFLCLP CPPGTYKPEG TPGGLSTCLL CPDQHHTSQP GSTAPSDCVC KQGYRSQGKT
CEVVYCPELF PPGNGFFIHN VCNNQFNAAC GVRCQPGYDR QGSGIRLCQP NGTWSGSPPS
CRVRSCPALT PPQHGHMNCT KGVASYRAAC EVRCAKGYKL EGDARLSCQA DSKWSGIQPR
CVEVRCPPMV TLRNVLLSPP ACGQRKVKPG TLCRLACRHG YRLQGDLEAR CLSSGDWSAN
VHKATCTDSE PPWVQCPRDV VAETDERRGT ANISWNVPTA TDNSGQEVLV QVKPVYTPPQ
LFPIGEERIT YVATDRAGNQ ANCTFTVTVI DTEPPVIDRC RSPPTFQATD MQTAVVWEVP
QFSDNSGGRL SVSTTHTPSS LFSVGETVVS YTAADQAGNN RTCDLTITVQ GSTCEQPFAP
VNGGFACSDE EDGVNCTLYC NAGYSFTQQT VHSYFCANNG VWEPPHSPDR PDCSLNRIAN
HGFKPFEMLF KASRCDDLDL VKSFTGEFNT KLRDMLPTIC SHDDVACKLE VISQGHCLEY
NYDYENGFAI GPGGWSSNLG PQSGQDYAYF DSGFATDSPR TPMQQDGSAR TGTSHYRSKR
HRKITSRDHK IQIFFNITAS IPQPSSRNDS VEVANQKRLL RILEQLTNRL KRTLAKQPLS
SYHVSSEMIV VADPKSLESK RASLFCRPGS VLKGRMCVQC PVGTYYSLEY AECESCWLGS
YQDQEGQMEC KTCPDGSSTA YLHARNQDEC KEQCKPGGYS VNGLETCESC PLGYYQPGLG
SRECLVCPDE TSTVTSGARE MAECGVPCLA GHFSRTGLVP CYPCPRDYYQ PDHGRSYCLS
CPFYGTTTIT GATAIQHCSS FGSSFLPKEE SVTSAPEVVV SQGYQASSQV FHECFLNPCQ
NRGTCEEVGA GYICTCLPGF TGAKCESDID ECDSAPCQNG GLCKDGTGDF LCQCRPGFVG
SLCEAEVNEC SSSPCLNEGV CVDEVNQYTC SCADGFTGSH CELEIDECLS SPCLNGGVCD
DLEGGYSCTC LPGYSGDRCE VNVDECNSAP CQNGGTCRDA VNNFRCQCVE GYRGRLCQVD
VDECQANPCI NGATCVDGLG SYTCRCPPGF NGTRCETEMS TSFNLDFEVS GIHGYVMMDG
MMPALTEITC TFWMRSSDTT NYGTPISYAV EGSDNAFLLI DYNGWVLYVN GKERITDCPA
VNTGQWHHIG VSWRSWDGDW RVYINGNPSD GGKGLSVGTT IPGGGALVLG QDQDQRGEGF
NPVESFVGSL SQLHIWDRVL DPQQIKILAN TCPGNNIRGN VLAWPDFLNG VVGRVKTNPN
CIFCADCPLL ENAVPHLRAS SPAVSPGSQT QLFCDPGFYL VGEPLLQCQN KGEWSHALPR
CERVTCGPPR PLEHGLFQGS DYHAGSTVVY QCNPGFYLLG DAKVLCTNSG KWGGNPPACL
DVDECALGSD CDEHASCHNT DGSYTCTCIY PYTGDGKNCT EPVKCENPGA PEFGYRDGSN
FLMGSEVVFS CEEGYELIGS SHVQCLETGS WNDIFPYCRA LSCGRPSVPE NAVMMGTNFT
FGSKVTFSCV KGFVPGDPYE MRCQASLKWS RAPPACQRVT CGDPPHVDNS DVTLKGKTYL
STVLYTCAEG YRLQGSEEVV CEASGEWSSP APSCASIQCG DPPALRDAAT IGNDHALGNK
VHYVCKEGYT LIGPETRECL STGQWSSTSA QCVPRSCGPP PSIDHAIAHA GHQLFGDMAN
YFCTDGYTAG NNSKVVCNAQ GEWAPTEGQE APHCIANFCQ RPTDLPHAIL DSVNKPKYAS
NTEVSYKCEE GFVLNTTATL KCMIGGEWMP SPYDVGCVPV RCSKPSGIER GYVSGTNYSF
GAVVAYSCDK GFLIRGEKRR TCKANGEWGG VLPVCQPVSC PFPPPLKNGF IQNKGRFFFN
SKVTYACNAG YRLTGRPVRL CQANRQWSNG DLPACHLLTC DPPPSILHGQ YQGSVFEVGR
KVKYICDEGY EISGDAVWTC LKYGKWDKLR RPHCSPVQCP EPPLEENHLV LRSLDSDSGT
VELSCEDGYV LHGARTLHCT PAQEWNDTFP VCKQVFCAPP PEVAFGDPSS APLSAPSYFS
SVVSYTCMDG FTLRKEGSVT CQADGHWSSP VPECIPVECP QPVEIANGIV DVQGLMYLST
ALYSCKPGYT LVGNATVLCG ESGLWIGGVP SCRPIECSVP KEIPNGKVAY TKLQFSHAVT
YSCRRGYRLQ GPETLKCLAN GQWDQETPVC VQIYCAPPNP IDNGFVEGLD HKFGVTIFYS
CFPGFQLVGQ NHLTCEEFDW SSSVPVCVPS DCGLPPHIDF GDYLRLLDPN AELAGRDTAI
TSKPIGGATV AFSLMDMRFL HGTVIVYRCH KGYELTAPMA LMCLEDGGWN GTAPMCVPAE
CEEPPSPDHG SVNITDTTLG SLVKYSCEQG YELEGESVRQ CVAGRQWSDV PPVCRPISCD
DPGNIDNGSN HVDSFLYLGV LHYECNSGFN LKGGDTRTCQ ADARWDGEKP WCEPISCGSP
VVPSDVTVKG KEYTFSKQVE LSCRAGLLLQ GPSVSVCQAD GTWSQGSPEC RPANCGRPTS
IQNGQVLGSD FGYGHEVWYK CEEGYSLSGG NPKRLCRGDG LWGEGPTPRC DIITCDPPQD
ISHGFLNGSS FNFDDVVEYV CFDGYEVIGD PVLRCSAQGH WVGTVPECLP CLCTPPMLRY
GVVLGRNHAC GDRVSFHCDE GYKILGPSAA TCEKGGLWSP GVPVCGRGRC VAAPPTIPHA
VQQGGGAGAA DTVTYRCRPG YQMKGSYPHV TCGREGRWGE VRISCEPVSC GAPTPVRHAQ
VVGEIFTFGS QIQYRCDEGY ELSSQSDSLS CQSEGTWSKQ SIRCRPAPCP LPANLPTHVM
VTGEDLTPVG GVVTLSCPTG FILQGPGLAE CQLGGSWSPG LSSVSCGLVV CEKPPLLPHG
ITEGDSYSYG DIVLYTCLPG FEMKGDSVQT CQGDRTWSGA QPTCVTVSCG PPPSVENAEV
QTSDEAYQGN VSYVCNPGLH LVGPQNLTCL ANGTWSLPAP TCKAGQGCDI PKALLNGRVQ
EESLTTGRAV AFQCDKGYAL KGDTLVVCMG DGTWSSTFPV CQPKPCPLPP RWKVSGGGVN
TSKQLFYVGQ SLPFACPKGH QAKRTAAITC RTDQTWTPVS TVCERVSCGP PLHVAHGVVR
GAVFQFGDVA VYSCFGGYAM EGHSRSVCLE NGTWTPPPAC RAMCWLQCLN GGVCQRPNTC
SCSEGWMGRL CEEPICILPC LNGGRCVAPY QCECPTGWMG TRCHSAVCLS PCLNGGRCIR
PNRCQCSPGW SGHDCSRKRK SGHFHF
//
