ID A0A1S3Z6M3_TOBAC Unreviewed; 409 AA.
AC A0A1S3Z6M3;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 28-JAN-2026, entry version 34.
DE SubName: Full=Transcription factor bHLH110 {ECO:0000313|RefSeq:XP_016460036.1};
GN Name=LOC107783563 {ECO:0000313|RefSeq:XP_016460036.1};
OS Nicotiana tabacum (Common tobacco).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae;
OC Nicotiana.
OX NCBI_TaxID=4097 {ECO:0000313|Proteomes:UP000790787, ECO:0000313|RefSeq:XP_016460036.1};
RN [1] {ECO:0000313|Proteomes:UP000790787}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24807620; DOI=10.1038/ncomms4833;
RA Sierro N., Battey J.N., Ouadi S., Bakaher N., Bovet L., Willig A.,
RA Goepfert S., Peitsch M.C., Ivanov N.V.;
RT "The tobacco genome sequence and its comparison with those of tomato and
RT potato.";
RL Nat. Commun. 5:3833-3833(2014).
RN [2] {ECO:0000313|RefSeq:XP_016460036.1}
RP IDENTIFICATION.
RC TISSUE=Leaf {ECO:0000313|RefSeq:XP_016460036.1};
RG RefSeq;
RL Submitted (AUG-2025) to UniProtKB.
CC -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR RefSeq; XP_016460036.1; XM_016604550.1.
DR RefSeq; XP_016460036.1; XM_016604550.2.
DR AlphaFoldDB; A0A1S3Z6M3; -.
DR STRING; 4097.A0A1S3Z6M3; -.
DR PaxDb; 4097-A0A1S3Z6M3; -.
DR GeneID; 107783563; -.
DR KEGG; nta:107783563; -.
DR OMA; FPINGDY; -.
DR OrthoDB; 1839773at2759; -.
DR Proteomes; UP000790787; Chromosome 12.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd11393; bHLH_AtbHLH_like; 1.
DR FunFam; 4.10.280.10:FF:000032; Transcription factor bHLH123 family; 1.
DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR InterPro; IPR045239; bHLH95_bHLH.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR045843; IND-like.
DR PANTHER; PTHR16223:SF56; TRANSCRIPTION FACTOR BHLH110; 1.
DR PANTHER; PTHR16223; TRANSCRIPTION FACTOR BHLH83-RELATED; 1.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR PROSITE; PS50888; BHLH; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000790787};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 287..336
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT REGION 238..294
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 352..371
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 244..260
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 409 AA; 44417 MW; 43FC2B9E87FF9457 CRC64;
MEPANLHHHH QQYHQLQFQD QLPLGISPNS SSSNSSYGDA TNTTHTWTPC TILNSAGTSL
SSYSSGAINT TNSSDPLLLR QQQQSGTNLV SMTQDLGFHW ANNSVSSQLV KQETSLDSYP
RFTQMLKSPS NIEERELSDM NAKLLFGTLS NSGCQMINTG LQLYPGDHNL LYSSNSSSST
NNRGKFSQIY PTINVSNLNI NQASYLANSS SLDMNLQPLD LVNTSRYGGS FSQPYGLTNH
FQHSSSESPV DSSSSISAFS NGVPEAKRTS NILEPKAPQN APKKSRVDSR ASCPPFKVRK
EKLGDRIAAL QQLVAPFGKT DTASVLMEAI GYIKFLQNQV ETLSVPYMKS SRNKTSRSLH
GGGGEMNGSE EVKRDLRSRG LCLVPLSCLT YMTDGGGGVW PPPNFAGGT
//
