ID A0A1S4B5B7_TOBAC Unreviewed; 1220 AA.
AC A0A1S4B5B7;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 28-JAN-2026, sequence version 2.
DT 28-JAN-2026, entry version 45.
DE SubName: Full=Late blight resistance protein R1-A-like isoform X2 {ECO:0000313|RefSeq:XP_016484145.2};
GN Name=LOC107804729 {ECO:0000313|RefSeq:XP_016484145.2};
OS Nicotiana tabacum (Common tobacco).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae;
OC Nicotiana.
OX NCBI_TaxID=4097 {ECO:0000313|Proteomes:UP000790787, ECO:0000313|RefSeq:XP_016484145.2};
RN [1] {ECO:0000313|Proteomes:UP000790787}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24807620; DOI=10.1038/ncomms4833;
RA Sierro N., Battey J.N., Ouadi S., Bakaher N., Bovet L., Willig A.,
RA Goepfert S., Peitsch M.C., Ivanov N.V.;
RT "The tobacco genome sequence and its comparison with those of tomato and
RT potato.";
RL Nat. Commun. 5:3833-3833(2014).
RN [2] {ECO:0000313|RefSeq:XP_016484145.2}
RP IDENTIFICATION.
RC TISSUE=Leaf {ECO:0000313|RefSeq:XP_016484145.2};
RG RefSeq;
RL Submitted (AUG-2025) to UniProtKB.
CC -!- FUNCTION: Confers resistance to late blight (Phytophthora infestans)
CC races carrying the avirulence gene Avr1. Resistance proteins guard the
CC plant against pathogens that contain an appropriate avirulence protein
CC via an indirect interaction with this avirulence protein. That triggers
CC a defense system including the hypersensitive response, which restricts
CC the pathogen growth. {ECO:0000256|ARBA:ARBA00002074}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Membrane {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}.
CC -!- SIMILARITY: Belongs to the disease resistance NB-LRR family.
CC {ECO:0000256|ARBA:ARBA00008894}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_016484145.1; XM_016628659.1.
DR RefSeq; XP_016484145.2; XM_016628659.2.
DR AlphaFoldDB; A0A1S4B5B7; -.
DR SMR; A0A1S4B5B7; -.
DR GeneID; 107804729; -.
DR OrthoDB; 1256185at2759; -.
DR Proteomes; UP000790787; Chromosome 20.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-ARBA.
DR GO; GO:0009626; P:plant-type hypersensitive response; IEA:UniProtKB-KW.
DR CDD; cd14798; RX-CC_like; 1.
DR FunFam; 3.40.50.300:FF:001091; Probable disease resistance protein At1g61300; 1.
DR FunFam; 1.10.10.10:FF:000322; Probable disease resistance protein At1g63360; 1.
DR Gene3D; 1.20.5.4130; -; 1.
DR Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR021929; R1A-like_N.
DR InterPro; IPR038005; RX-like_CC.
DR InterPro; IPR041118; Rx_N.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR058922; WHD_DRP.
DR PANTHER; PTHR23155:SF1152; AAA+ ATPASE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR23155; DISEASE RESISTANCE PROTEIN RP; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF12061; NB-LRR; 1.
DR Pfam; PF18052; Rx_N; 1.
DR Pfam; PF23559; WHD_DRP; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Hypersensitive response {ECO:0000256|ARBA:ARBA00022667};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Plant defense {ECO:0000256|ARBA:ARBA00022821};
KW Reference proteome {ECO:0000313|Proteomes:UP000790787};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
SQ SEQUENCE 1220 AA; 141559 MW; 64ECA93E6D408688 CRC64;
MLDISQKVQA LFQDALVDFS ELHLAEYFNF CIFKVQNKIW LIKMEIRAKY SFPKISSLPL
ISAKKNGSDI PKFVMDFMDT VVEILRDLVD DPCSSLLYVP ETNEHVEDVL KELKLLRTFV
CFVSERFIEP QSQHLANFFT HVLAVAGHAS MLVWLYFSSY GYEDRDVAVL GEINVFLFLQ
MKFKPIQPSI RKIYIALLEV LKSRIQSGWC PNIQNHEHAA DSEANFLETI QQDLAELPTN
SNFSQSDALK DQLVILKEML DILRADIIHV PIRDLEVLLR DIDTFIIDVG LVVYSLYKGE
EEEKEVVAVG EVNPALVLDL LGNIQKIIIT EKLMPIRKAF HSNYLPRIHG LGYVDFILKN
LKEFQSRHLD SLASTTKLLQ RIQKELESWQ PFLESVAEEQ HNDIDKIQRC ATQLIGKAYE
IEYLIDACIC EKAPVWCLEH WFLDIVEDTI LVKDEVTEIH EKKMVEDALI NTVTTRTTSN
LERSPRMNEE IVGFDDVVEN LREQLVKGTK GRDVISIVGM PGLGKTTLAY RLYSDRLVVS
HFDIRADCCV SQVYSRKNLL LAILRDVISE NSEFREKKAD ELADLLRKAL FSKRYLILVD
DVWEASVWDD LICCFQDANN GSRIILTTRN HEIAEYAKFQ SNPFSLRMFN NEESWKLLRK
KVFGEESCPS LLMNIGRQIA EKCGQLPLSI ALVAGVLAEV EKKEECWEQV ANNLVPHIHN
DSRAIIENSY QILPYHLRSC FLYFGAFLED NVINVSKLIR LWISEGFVKG CEGKSLEDIA
EGYLGNLIGR NLVMGTKRSF RGKIKACRIH DLLHDFCKVR AKEENLVQWM KWEQTANPSS
NISCLEQLAH RMSIYGKWYR IGEWSTCWSR VGSIILLNDC LAFDIVSQIF YSFKFLKVLD
LQFTTIDSFP TDLVYLRYFA AQTHKSLDIS IITNCWNLET LILHNYGAMS LPLTLWNMVN
LRNLHIFRCS FNIKYAKYSL ENSKSLYGLR TFSAPYFSCV EDAELILRKT PNLRELKCTF
LDEDVDKFRY YVLNFPTEIE TLKIYCPYFC KLTIPFCISA PNLKNLTLER YCLHPQHLST
IALLQNLQVL KMKSIKFEKK VWEVSNGDFP ELKVLKLQEI FCFEEWDVTD DEAFPKLERL
VLRECEYLKE IPSAFGEISS LKYIEVRKCP ESVDKSARDI REIQVEDYQN TGFEIFIRER
RKYQLLLRKI CENITKQLSN
//
