ID A0A1T4TAG4_9ACTN Unreviewed; 629 AA.
AC A0A1T4TAG4;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 28-JAN-2026, entry version 37.
DE RecName: Full=Selenocysteine-specific elongation factor {ECO:0000256|ARBA:ARBA00015953};
DE AltName: Full=SelB translation factor {ECO:0000256|ARBA:ARBA00031615};
GN ORFNames=SAMN02745673_04695 {ECO:0000313|EMBL:SKA37376.1};
OS Marinactinospora thermotolerans DSM 45154.
OC Bacteria; Bacillati; Actinomycetota; Actinomycetes; Streptosporangiales;
OC Nocardiopsidaceae; Marinactinospora.
OX NCBI_TaxID=1122192 {ECO:0000313|EMBL:SKA37376.1, ECO:0000313|Proteomes:UP000190637};
RN [1] {ECO:0000313|EMBL:SKA37376.1, ECO:0000313|Proteomes:UP000190637}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 45154 {ECO:0000313|EMBL:SKA37376.1,
RC ECO:0000313|Proteomes:UP000190637};
RA Peterson S.W.;
RL Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Translation factor necessary for the incorporation of
CC selenocysteine into proteins. It probably replaces EF-Tu for the
CC insertion of selenocysteine directed by the UGA codon. SelB binds GTP
CC and GDP. {ECO:0000256|ARBA:ARBA00025526}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR EMBL; FUWS01000017; SKA37376.1; -; Genomic_DNA.
DR RefSeq; WP_078763914.1; NZ_FUWS01000017.1.
DR AlphaFoldDB; A0A1T4TAG4; -.
DR STRING; 1122192.SAMN02745673_04695; -.
DR OrthoDB; 9803139at2; -.
DR Proteomes; UP000190637; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:TreeGrafter.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
DR GO; GO:0001514; P:selenocysteine incorporation; IEA:InterPro.
DR CDD; cd04171; SelB; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR057335; Beta-barrel_SelB.
DR InterPro; IPR050055; EF-Tu_GTPase.
DR InterPro; IPR004161; EFTu-like_2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR015191; SelB_WHD4.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR004535; Transl_elong_SelB.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR NCBIfam; TIGR00475; selB; 1.
DR PANTHER; PTHR43721:SF22; ELONGATION FACTOR TU, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43721; ELONGATION FACTOR TU-RELATED; 1.
DR Pfam; PF25461; Beta-barrel_SelB; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF03144; GTP_EFTU_D2; 1.
DR Pfam; PF09107; WHD_3rd_SelB; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR PROSITE; PS51722; G_TR_2; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Elongation factor {ECO:0000313|EMBL:SKA37376.1};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00023134};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000190637}.
FT DOMAIN 1..169
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
FT REGION 589..629
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 629 AA; 66582 MW; 0C2B9D056A3EACA4 CRC64;
MHVVATAGHV DHGKSTLVRA LTGMEPDRWR AERERGLTID LGFAWTRLPS GRRVAFVDVP
GHERFVPNTL AGLGPVPAVL FVVAADGGWM PQSAEHLAAL DALGVGHGLL VVTRADLADP
TPARRVALER IAATTLGEIP SVVVSGVTGE GMAELRAGVD ALVGRLPPAD PDADVRLWVD
RSFTVGGSGT VVTGTLGAGT VRAGDTLLLS STGEQVRVRA VESLGEAVAE QRAVARVALN
LRGVERSRVR RGDALLSPGV WRLTDAIDVE LRGSAEAPPP RQAMLHVGSA AVPVETRPLG
AAWARLRLAR PLPLRFGDTA LLRDPGAHRI VAGVRVLDVD PPPLRHRGAP ARRAAELAAI
VAGGAREAAR SRLLRSGFVP VGEPRVLGLP ALGEVRAGFH VAPEAWARLR SRLGSVVAAW
RGHRPLEPGP PVEQVRRELG LPAPRLVTLL ARECGLEVRE GRVLSPDAVG DLPPRVRGSL
ERLARDLRRA PFAAPDTPRL AELGLGPREI AASVRAGRLM RVAEGVVLLP GAVEQAHAEL
SRLPQPFTVS AARRALATSR RVAVPLLELL DRRGLTRRLD ADLREVVGEP GRVGTAFPRP
EEASARPGPR RGPARCAPPP PGRDRGPAA
//
