ID A0A1T4TFI3_9HYPH Unreviewed; 629 AA.
AC A0A1T4TFI3;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 28-JAN-2026, entry version 32.
DE RecName: Full=Selenocysteine-specific elongation factor {ECO:0000256|ARBA:ARBA00015953};
DE AltName: Full=SelB translation factor {ECO:0000256|ARBA:ARBA00031615};
GN ORFNames=SAMN02745126_06140 {ECO:0000313|EMBL:SKA38959.1};
OS Enhydrobacter aerosaccus.
OC Bacteria; Pseudomonadati; Pseudomonadota; Alphaproteobacteria;
OC Hyphomicrobiales; Enhydrobacter.
OX NCBI_TaxID=225324 {ECO:0000313|EMBL:SKA38959.1, ECO:0000313|Proteomes:UP000190092};
RN [1] {ECO:0000313|Proteomes:UP000190092}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 27094 {ECO:0000313|Proteomes:UP000190092};
RA Varghese N., Submissions S.;
RL Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Translation factor necessary for the incorporation of
CC selenocysteine into proteins. It probably replaces EF-Tu for the
CC insertion of selenocysteine directed by the UGA codon. SelB binds GTP
CC and GDP. {ECO:0000256|ARBA:ARBA00025526}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR EMBL; FUWJ01000016; SKA38959.1; -; Genomic_DNA.
DR RefSeq; WP_170921235.1; NZ_FUWJ01000016.1.
DR AlphaFoldDB; A0A1T4TFI3; -.
DR STRING; 225324.SAMN02745126_06140; -.
DR Proteomes; UP000190092; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0004020; F:adenylylsulfate kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
DR GO; GO:0001514; P:selenocysteine incorporation; IEA:InterPro.
DR CDD; cd04171; SelB; 1.
DR CDD; cd15491; selB_III; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 3.
DR InterPro; IPR057335; Beta-barrel_SelB.
DR InterPro; IPR050055; EF-Tu_GTPase.
DR InterPro; IPR004161; EFTu-like_2.
DR InterPro; IPR015190; Elong_fac_SelB-wing-hlx_typ-2.
DR InterPro; IPR031157; G_TR_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR015191; SelB_WHD4.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR009001; Transl_elong_EF1A/Init_IF2_C.
DR InterPro; IPR004535; Transl_elong_SelB.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR InterPro; IPR048931; WHD_2nd_SelB_bact.
DR NCBIfam; TIGR00475; selB; 1.
DR PANTHER; PTHR43721; ELONGATION FACTOR TU-RELATED; 1.
DR PANTHER; PTHR43721:SF11; SELENOCYSTEINE-SPECIFIC ELONGATION FACTOR; 1.
DR Pfam; PF25461; Beta-barrel_SelB; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF03144; GTP_EFTU_D2; 1.
DR Pfam; PF09106; WHD_2nd_SelB; 1.
DR Pfam; PF21214; WHD_2nd_SelB_bact; 1.
DR Pfam; PF09107; WHD_3rd_SelB; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR SUPFAM; SSF50465; EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 3.
DR PROSITE; PS00301; G_TR_1; 1.
DR PROSITE; PS51722; G_TR_2; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Elongation factor {ECO:0000313|EMBL:SKA38959.1};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000190092}.
FT DOMAIN 1..169
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
SQ SEQUENCE 629 AA; 68094 MW; A6F622CB28766039 CRC64;
MIVGTAGHID HGKTALVKAL TGVDADRLKE EKARGITIDL GYAYSDLGDG RQLGFVDVPG
HERFVHNMLA GATGIDAALL VVAATEGIKP QTIEHLQIID LLGLDRGLVA LTKADLATDD
QLLERMTEVE TLLASTSLAG AEIVPVSAVT GQGIQELKAK LLTLGESGKG TTGFARLAVD
RSFVLSGAGI VVTGTVHAGE IKVDDRLLLT PSGLDARVRS LHAQNRPAGI GRAGERCALN
LAGPKLSKES VRRGDWVVSP ELHAPTDRLD IRLKLLASEP QPLKHWSPVH VHLAAAHVMG
RVALLEGDHL APGGSGLAQL VLEEKIGALA GDRVILRDPS ATRTMAGGTV IDPFGPPRNR
RTPRRLAELS TLAQPDPFTR LLALDGGFVD LGRYGLAHNQ RPEDLERHLA DADGVRVQGF
GFLPTTMEQI RRDIAETLTA FHKSNADAPG MQPERLRVSL KQRWPAPVFR ALLDGEVAAK
TLVLDGGFVR LPGHSLTLAP RDEALWRKIS AELARDRFKP PRVRDFAQTY REPEPNVRKL
MRQLARLGQV VEVAPDQFFL RPVVAEMIAI ADGLGADFTA AQFRDKLDNG RKLAILILEF
FDRHGITVRR GDLRRTMPQK LGQYGPPPA
//
