ID A0A1T4VXB5_9BACT Unreviewed; 636 AA.
AC A0A1T4VXB5;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 28-JAN-2026, entry version 36.
DE RecName: Full=Selenocysteine-specific elongation factor {ECO:0000256|ARBA:ARBA00015953};
DE AltName: Full=SelB translation factor {ECO:0000256|ARBA:ARBA00031615};
GN ORFNames=SAMN02745702_01161 {ECO:0000313|EMBL:SKA69577.1};
OS Desulfobaculum bizertense DSM 18034.
OC Bacteria; Pseudomonadati; Thermodesulfobacteriota; Desulfovibrionia;
OC Desulfovibrionales; Desulfovibrionaceae; Desulfobaculum.
OX NCBI_TaxID=1121442 {ECO:0000313|EMBL:SKA69577.1, ECO:0000313|Proteomes:UP000189733};
RN [1] {ECO:0000313|EMBL:SKA69577.1, ECO:0000313|Proteomes:UP000189733}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 18034 {ECO:0000313|EMBL:SKA69577.1,
RC ECO:0000313|Proteomes:UP000189733};
RA Peterson S.W.;
RL Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Translation factor necessary for the incorporation of
CC selenocysteine into proteins. It probably replaces EF-Tu for the
CC insertion of selenocysteine directed by the UGA codon. SelB binds GTP
CC and GDP. {ECO:0000256|ARBA:ARBA00025526}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; FUYA01000003; SKA69577.1; -; Genomic_DNA.
DR RefSeq; WP_078684461.1; NZ_FUYA01000003.1.
DR AlphaFoldDB; A0A1T4VXB5; -.
DR STRING; 1121442.SAMN02745702_01161; -.
DR OrthoDB; 9803139at2; -.
DR Proteomes; UP000189733; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:TreeGrafter.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
DR GO; GO:0001514; P:selenocysteine incorporation; IEA:InterPro.
DR CDD; cd04171; SelB; 1.
DR CDD; cd03696; SelB_II; 1.
DR CDD; cd15491; selB_III; 1.
DR FunFam; 3.40.50.300:FF:001064; Selenocysteine-specific translation elongation factor; 1.
DR Gene3D; 1.10.10.2770; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR057335; Beta-barrel_SelB.
DR InterPro; IPR050055; EF-Tu_GTPase.
DR InterPro; IPR004161; EFTu-like_2.
DR InterPro; IPR015190; Elong_fac_SelB-wing-hlx_typ-2.
DR InterPro; IPR031157; G_TR_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR015191; SelB_WHD4.
DR InterPro; IPR005225; Small_GTP-bd.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR009001; Transl_elong_EF1A/Init_IF2_C.
DR InterPro; IPR004535; Transl_elong_SelB.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR NCBIfam; TIGR00475; selB; 1.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR43721:SF22; ELONGATION FACTOR TU, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43721; ELONGATION FACTOR TU-RELATED; 1.
DR Pfam; PF25461; Beta-barrel_SelB; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF03144; GTP_EFTU_D2; 1.
DR Pfam; PF09106; WHD_2nd_SelB; 1.
DR Pfam; PF09107; WHD_3rd_SelB; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR SUPFAM; SSF50465; EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 3.
DR PROSITE; PS00301; G_TR_1; 1.
DR PROSITE; PS51722; G_TR_2; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Elongation factor {ECO:0000313|EMBL:SKA69577.1};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000189733}.
FT DOMAIN 1..171
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
SQ SEQUENCE 636 AA; 70532 MW; 43CFE73127B76E4D CRC64;
MPVIMGTAGH IDHGKTTLVK ALTGIDCDRL AEEKKRGITI ELGFAYVDLP DGQRVSIVDV
PGHERFVKNM VAGASGIDFV VLVIAADEGV MPQTREHLEI CTLLGIEKGM VVLTKADSVD
EEWMELVRED VSEFLAGSFL EDAPVLAVSS HTGQGLDELR AELQKLVNGL KGQSRSDLMR
LPVDRVFSIK GHGTVVTGTL LSGSVSVGDD VELFPSGQMS KVRSVQSHEE SVEKGLAGRR
TAINLAGLEV ADVQRGEVLG RPESLFPSLV WDVELKYLPS AGRELKHRKE LHFHHGTRDV
LARVSFPDRD KVLPGETVLC QVRFQEPMVG VYGDRVVLRS FSPLRTIAGG RIINPFGRKM
KRFRDESTAQ LQQLADGTSE DVIRTQLELS RAEGLSFAQL LTACGLEKKA LEKVLSKLMS
RSEIFLYDKE SRSYISGREV ERLCDAAEAA VRAYHEAEPM KQGIVRGELA SGWGRRLAPK
LFHFLSERLL RQKRLVAEAE LLRLPQHKVS LASDQEKLKQ LLVEAYASKG ETPPNLKDVL
EPLDLTFREA APVFKLLLDA GELVKVKEEM YYHAPALAGI VDKVRAFITE HGAMSAADFK
TLSGLSRKFA IPVLEYMDRE RITMRVGDDR MLRAQR
//
