ID A0A1U7QJE0_MESAU Unreviewed; 602 AA.
AC A0A1U7QJE0;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 18-JUN-2025, entry version 39.
DE SubName: Full=Ligand-dependent nuclear receptor corepressor-like protein isoform X3 {ECO:0000313|RefSeq:XP_005068848.1};
GN Name=Lcorl {ECO:0000313|RefSeq:XP_005068848.1};
OS Mesocricetus auratus (Golden hamster).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Mesocricetus.
OX NCBI_TaxID=10036 {ECO:0000313|Proteomes:UP000189706, ECO:0000313|RefSeq:XP_005068848.1};
RN [1] {ECO:0000313|RefSeq:XP_005068848.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (MAR-2025) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00320}.
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DR RefSeq; XP_005068848.1; XM_005068791.3.
DR AlphaFoldDB; A0A1U7QJE0; -.
DR STRING; 10036.ENSMAUP00000022404; -.
DR Ensembl; ENSMAUT00000026402; ENSMAUP00000022404; ENSMAUG00000019848.
DR eggNOG; KOG4565; Eukaryota.
DR Proteomes; UP000189706; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:TreeGrafter.
DR FunFam; 1.10.10.60:FF:000019; Ligand-dependent corepressor isoform 1; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 2.
DR InterPro; IPR009057; Homeodomain-like_sf.
DR InterPro; IPR007889; HTH_Psq.
DR PANTHER; PTHR21545:SF10; LIGAND-DEPENDENT NUCLEAR RECEPTOR COREPRESSOR-LIKE PROTEIN; 1.
DR PANTHER; PTHR21545; TRANSCRIPTION FACTOR MLR1/2; 1.
DR Pfam; PF05225; HTH_psq; 2.
DR SUPFAM; SSF46689; Homeodomain-like; 2.
DR PROSITE; PS50960; HTH_PSQ; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00320};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00320}; Reference proteome {ECO:0000313|Proteomes:UP000189706};
KW Transcription {ECO:0000256|ARBA:ARBA00023015};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 517..569
FT /note="HTH psq-type"
FT /evidence="ECO:0000259|PROSITE:PS50960"
FT DNA_BIND 545..565
FT /note="H-T-H motif"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00320"
FT REGION 105..126
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 498..522
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 565..602
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 107..124
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 589..602
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 602 AA; 66955 MW; 7F15B9E7450BC3AB CRC64;
MDKGRERMAA AAAAAAAAAA AAAQCRSPRC AAERRGFRRE LDSWRHRLMH CVGFESILEG
LYGPRLRRDL SLFEDCEPEE LTDWSMDEKC SFCNLQREAV SDCIPSLDSS QSTPTEELSS
QGQSHTDKIE CQAENYLNAL FRKKDLPQNC DPNIPLVAQE LMKKMIRQFA IEYISKSGKI
QENRNGSIGA SLVYKSIQMN QAENCLQDEQ EGPLDLTVTR TQEQTAQQGD GVLDLSTKKT
SIKSEESPIC DPSSENAVAG RLHRNREDYV ERSAEFADGL LSKALKDIQS GALDINKAGI
LYGIPQKTLL LHLEALPAGK PASFKNKTRD FNDSYSYKDS KETCAVLQKV ALWARAQAER
TEKSKLNLLE TSELKFPTAS SYLHQLTLQK MVTQFKEKNE SLQYETSNPP VQLKIPQLRV
NSVSKSQPDG SGLLDVMYQV SKTSSVLEGS ALQKLKNILP KQNKIECSGP VTHSSVDSYF
LHGDLSPLCL NSKNGTIDGT SENTEDGLDR KDNKQPRKKR GRYRQYDHEI MEEAIAMVMS
GKMSVSKAQG IYGVPHSTLE YKVKERSGTL KTPPKKKLRL PDTGLYMTDS GTGSCRNSSK
PV
//
