ID A0A1U7QS36_MESAU Unreviewed; 2417 AA.
AC A0A1U7QS36;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 18-JUN-2025, entry version 40.
DE RecName: Full=Nucleoprotein TPR {ECO:0000256|ARBA:ARBA00019789};
DE AltName: Full=Megator {ECO:0000256|ARBA:ARBA00083105};
DE AltName: Full=NPC-associated intranuclear protein {ECO:0000256|ARBA:ARBA00077074};
DE AltName: Full=Translocated promoter region protein {ECO:0000256|ARBA:ARBA00079318};
GN Name=Tpr {ECO:0000313|RefSeq:XP_005073531.1};
OS Mesocricetus auratus (Golden hamster).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Mesocricetus.
OX NCBI_TaxID=10036 {ECO:0000313|Proteomes:UP000189706, ECO:0000313|RefSeq:XP_005073531.1};
RN [1] {ECO:0000313|RefSeq:XP_005073531.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (MAR-2025) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Chromosome, centromere, kinetochore
CC {ECO:0000256|ARBA:ARBA00004629}. Cytoplasm, cytoskeleton, spindle
CC {ECO:0000256|ARBA:ARBA00004186}. Nucleus membrane
CC {ECO:0000256|ARBA:ARBA00004335}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004335}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004335}. Nucleus membrane
CC {ECO:0000256|ARBA:ARBA00004620}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004620}; Nucleoplasmic side
CC {ECO:0000256|ARBA:ARBA00004620}. Nucleus, nuclear pore complex
CC {ECO:0000256|ARBA:ARBA00004567}.
CC -!- SIMILARITY: Belongs to the TPR family. {ECO:0000256|ARBA:ARBA00005274}.
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DR RefSeq; XP_005073531.1; XM_005073474.3.
DR SMR; A0A1U7QS36; -.
DR STRING; 10036.ENSMAUP00000024450; -.
DR GeneID; 101825058; -.
DR KEGG; maua:101825058; -.
DR CTD; 7175; -.
DR eggNOG; KOG4674; Eukaryota.
DR OrthoDB; 343070at2759; -.
DR Proteomes; UP000189706; Unplaced.
DR GO; GO:0034399; C:nuclear periphery; IEA:UniProtKB-ARBA.
DR GO; GO:0005643; C:nuclear pore; IEA:UniProtKB-ARBA.
DR GO; GO:0017056; F:structural constituent of nuclear pore; IEA:TreeGrafter.
DR GO; GO:0006406; P:mRNA export from nucleus; IEA:TreeGrafter.
DR GO; GO:0006606; P:protein import into nucleus; IEA:InterPro.
DR GO; GO:1901673; P:regulation of mitotic spindle assembly; IEA:TreeGrafter.
DR FunFam; 1.10.287.1490:FF:000004; nucleoprotein TPR isoform X2; 1.
DR FunFam; 1.10.287.1490:FF:000005; nucleoprotein TPR isoform X2; 1.
DR Gene3D; 1.10.287.1490; -; 2.
DR InterPro; IPR012929; TPR/MLP1.
DR PANTHER; PTHR18898:SF2; NUCLEOPROTEIN TPR; 1.
DR PANTHER; PTHR18898; NUCLEOPROTEIN TPR-RELATED; 1.
DR Pfam; PF25481; Nucleoprot-TPR; 1.
DR Pfam; PF07926; TPR_MLP1_2; 1.
PE 3: Inferred from homology;
KW Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Cell division {ECO:0000256|ARBA:ARBA00022618};
KW Centromere {ECO:0000256|ARBA:ARBA00023328};
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Kinetochore {ECO:0000256|ARBA:ARBA00022838};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Methylation {ECO:0000256|ARBA:ARBA00022481};
KW Mitosis {ECO:0000256|ARBA:ARBA00022776};
KW mRNA transport {ECO:0000256|ARBA:ARBA00022816};
KW Nuclear pore complex {ECO:0000256|ARBA:ARBA00023132};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000189706};
KW Translocation {ECO:0000256|ARBA:ARBA00023010};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 1095..1222
FT /note="Nucleoprotein TPR/MLP1"
FT /evidence="ECO:0000259|Pfam:PF07926"
FT REGION 1..54
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 972..991
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1504..1526
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1538..1578
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1675..1730
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1859..2188
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2281..2417
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 85..337
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 377..422
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 483..569
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 599..652
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 721..857
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1152..1225
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1277..1479
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 38..54
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 972..982
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1513..1526
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1560..1569
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1675..1687
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1689..1708
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1859..1884
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1923..1937
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1940..1949
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1980..1991
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2002..2043
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2053..2074
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2080..2090
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2091..2104
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2281..2298
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2299..2308
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2313..2326
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2327..2337
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2339..2353
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2354..2374
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2406..2417
FT /note="Gly residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2417 AA; 272574 MW; 834CC402D5BC658D CRC64;
MASRGFDGSR RGSLRRAGAR EPASDAADGT PQASGFRASP SSFVSPSAAA ATTPADMAAV
LQQVLERPEL NKLPKSTQNK LEKFLADQQS EIDGLKGRHE KFKVESEQQY FEIEKRLSQS
QERLVNETRE CQNLRLELEK LNNQVKVLTE KNKELETSQD RNLGIQSQFT RAKEELEAEK
RDLIRTNERL SQEVEYLTED VKRLNEKLKE SNTTKGELQL KLDELQASDV AVKYREKRLE
QEKELLQNQN SWLNTELKTK TDELLALGRE KGNEILELKC NLENKKEEVL RLEEQMNGLK
TSNEHLQKHV EDLLTKLKEA KEQQASMEEK FHNELNAHIK LSNLYKSAAD DSEAKSNELT
RAVDELHKLL KEAGEANKTI QDHLLQAEES KDQMEKEMLE KIGKLEKELE NANDLLSATK
RKGAILSEEE LAAMSPTAAA VAKIVKPGMK LTELYNAYVE TQDQLLLEKL ENKRINKYLD
EIVKEVEAKA PILKRQREEY ERAQKAVASL SAKLEQAMKE IQRLQEETDK ANKHSSVLER
DNQRMEVQIK DLSQQIRVLL MELEEARGNH VIRDEEVSSA DISSSSEVIS QHLVSYRNIE
ELQQQNQRLL FALRELGETR EREEQETTSS KISELQHKLE NSLTELEQLR ESRQHQMQLV
DSIVRQRDMY RILLSQTTGM AIPLQSSSLD DISLVSTPKR SSTSQTASTP APVSVIESTE
AIEARAALKQ LQEIFENYKK EKIDSEKLQN EQLEKLQEQV TDLRSQNTKI STQLDFASKR
YEMLQDNVEG YRREITSLQE RNQKLTATTQ KQEQIINTMT QDLRGANEKL AVAEVRADNL
KKEKEMLKLS EVRLSQQRES LLAEQRGQNL LLTNLQTIQG ILERSETETK QRLSNQIEKL
EHEISHLKKK LENELEQRHT LTRNLDVQLL DTKRQLDTEI NLHLNTKELL KNAQKEIATL
KQHLNNMEVQ LASQSTQRSG KGQPSDRDDV DDLMSQLRQA EEQVNDLKER LKTSTSNVEQ
YRAMVTSLED SLNKEKQVTE EVHKNIEVRL KESAEFQTQL EKKLMEVEKE KQELQDDKRK
AIESMEQQLS ELKKTLSSVQ NEVQEALQRA STALSNEQQA RRDCQEQAKI AVEAQNKYER
ELMLHAADVE ALQAAKEQVS KMTSVRQHLE ETAQKAESQL LACKASWEER ERVLKDEVSK
SVSRCEDLEK QNRLLHDQIE KLSDKVVASM KEVVQTPLNV SVSEEGKSQE QILEILRFIR
REKEIAETRF EVAQVESLRY RQRVELLERE LQELQDSLNA EREKVQVTAK TMAQHEELMK
KTETMNVVME TNKMLREEKE RLEQNLQQMQ AKVRKLELDI LPLQEANAEL SEKSGMLQAE
KKLLEEDVKR WKARNQHLVN QQKDPDTEEY RKLLSEKEIH TKRIQQLNEE VGRLKAEIAR
SNASLTNNQN LIQSLKEDLN KVRNEKDNIQ KDLDAKIIDI QEKVKTITQV KKIGRRYKTQ
YEELKAQQDK AMESSTQSSG DHQEQHISVQ EMQELKDTLN QSETKTKSLE GQVENLQKTL
SEKETEARSL QEQTAQLQSE LSRLRQDLQD RTTQEEQLRQ QITEKDEKTR KAIVAAKSKI
AHLAGVKDQL TKENEELKQR NGALDQQKDE LDVRMTALKS QYEGRISRLE RELREHQERH
LEQRDEPQEP TNKAPEQQRQ ITLKTTPASG ERGIASTSDP PTANIKPTPV VSTPSKVTAA
AMAGNKSTPR ASIRPMVTPA TVTNPTTTPT ATVMPTTQVE SQEALQSEGP VEHVTVFGST
SGSVRSTSPN VQPSISQPIL TVQQQTQATA FVQPTQQSHP QIEPANQELS PNIVEVVQSS
PVERPSTSTA GFGTVSATPS SSLPKRTREE EEDSAAEAAE QVPDDTVEMP LPKKLKTVTP
VGTEEEVMAE ESTDGEVETQ VYNQDSQDSI GEGVTQGDYT PMEDSEETSQ SLQIDLGPLQ
SDQQTTSSQD GQGKGDDVIV IDSDDEDDDE ENDGEHEDYE EDEDDDDDDE DDTGMGDEGE
DSNEGTGSAD GNDGYEADDA EGGDGTDPGT ETEESMGGAE SNQRAADSQN SGEGSTSAAE
SSFSQEVARE QQPSSASERQ TPRAPQSPRR PPHPLPPRLT IHAPPQELGP PVQRIQMTRR
QSVGRGLQLT PGIGGMQQHF FDDEDRTVPS TPTLVVPHRT DGFAEAIHSP QVAGVPRFRF
GPPEDMPQTS SSHSDLGQLA SQGGLGMYET PLFLAHEEES GGRSVPTTPL QVAAPVTVFT
ESTTSDASEH ASQSVPMVTT STGTLSTTNE SAAGDDGDEV FVEAESEGIS SEAGLEIDSQ
QEEEPVQASD ESDLPSTSQD PPSSSSVDTS SSQPKPFRRV RLQTTLRQGV RGRQFNRQRG
VSHAMGGRGG INRGNIN
//
