ID A0A1U7TNT8_CARSF Unreviewed; 236 AA.
AC A0A1U7TNT8;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 28-JAN-2026, entry version 35.
DE SubName: Full=Coiled-coil domain-containing protein 103 isoform X2 {ECO:0000313|RefSeq:XP_008054727.1, ECO:0000313|RefSeq:XP_021567267.1};
GN Name=CCDC103 {ECO:0000313|RefSeq:XP_008054727.1,
GN ECO:0000313|RefSeq:XP_021567267.1, ECO:0000313|RefSeq:XP_021567268.1};
OS Carlito syrichta (Philippine tarsier) (Tarsius syrichta).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Tarsiiformes; Tarsiidae;
OC Carlito.
OX NCBI_TaxID=1868482 {ECO:0000313|RefSeq:XP_008054727.1};
RN [1] {ECO:0000313|RefSeq:XP_008054727.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Dynein-attachment factor required for cilia motility.
CC {ECO:0000256|ARBA:ARBA00004048}.
CC -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738}.
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium, flagellum
CC {ECO:0000256|ARBA:ARBA00004230}. Cytoplasm
CC {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the DNAAF19/PR46b family.
CC {ECO:0000256|ARBA:ARBA00049986}.
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DR RefSeq; XP_008054727.1; XM_008056536.2.
DR RefSeq; XP_021567267.1; XM_021711592.1.
DR RefSeq; XP_021567268.1; XM_021711593.1.
DR AlphaFoldDB; A0A1U7TNT8; -.
DR STRING; 1868482.ENSTSYP00000006625; -.
DR GeneID; 103258859; -.
DR KEGG; csyr:103258859; -.
DR CTD; 388389; -.
DR OMA; YRNWRRH; -.
DR OrthoDB; 447931at2759; -.
DR Proteomes; UP000189704; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:GOC.
DR GO; GO:0031514; C:motile cilium; IEA:UniProtKB-SubCell.
DR GO; GO:0036157; C:outer dynein arm; IEA:InterPro.
DR GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR GO; GO:0071907; P:determination of digestive tract left/right asymmetry; IEA:Ensembl.
DR GO; GO:0003351; P:epithelial cilium movement involved in extracellular fluid movement; IEA:TreeGrafter.
DR GO; GO:0001947; P:heart looping; IEA:Ensembl.
DR GO; GO:0036159; P:inner dynein arm assembly; IEA:Ensembl.
DR GO; GO:0036158; P:outer dynein arm assembly; IEA:Ensembl.
DR InterPro; IPR042422; CC103.
DR InterPro; IPR031733; Dynein_attach_N.
DR InterPro; IPR025986; RPAP3-like_C.
DR PANTHER; PTHR28572; COILED-COIL DOMAIN-CONTAINING PROTEIN 103; 1.
DR PANTHER; PTHR28572:SF1; COILED-COIL DOMAIN-CONTAINING PROTEIN 103; 1.
DR Pfam; PF15867; Dynein_attach_N; 1.
DR Pfam; PF13877; RPAP3_C; 1.
PE 3: Inferred from homology;
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Cilium biogenesis/degradation {ECO:0000256|ARBA:ARBA00022794};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Flagellum {ECO:0000256|ARBA:ARBA00022846};
KW Reference proteome {ECO:0000313|Proteomes:UP000189704}.
FT DOMAIN 7..74
FT /note="Dynein attachment factor N-terminal"
FT /evidence="ECO:0000259|Pfam:PF15867"
FT DOMAIN 99..188
FT /note="RNA-polymerase II-associated protein 3-like C-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF13877"
FT REGION 63..101
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 75..90
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 236 AA; 26466 MW; D699042A0B2202EB CRC64;
MERNDVIDFK VLEKELQAAL AADEKYKREN AAKLRAVEQR VASYEEFRGI ILASHLKPLE
RKDKAGGKRS VPWNCHTTQG RTSQDVATEI SQEKSPLEPQ TSAEFYRDWR RHLRSGPERY
QALLQLGGLK LGHLFQTDVG FGLLGELLVA LADHVRPADR AAVLGILRSL AGTGRFPLNL
SLLSQEERES CKRLFRKLQA LGAPRPAEEQ GLEAQTGELR VEDGALQELL ALYQVD
//
