ID A0A1U7YS76_NICSY Unreviewed; 374 AA.
AC A0A1U7YS76;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 28-JAN-2026, entry version 37.
DE SubName: Full=1-aminocyclopropane-1-carboxylate oxidase homolog {ECO:0000313|RefSeq:XP_009802074.1};
GN Name=LOC104247695 {ECO:0000313|RefSeq:XP_009802074.1};
OS Nicotiana sylvestris (Wood tobacco) (South American tobacco).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae;
OC Nicotiana.
OX NCBI_TaxID=4096 {ECO:0000313|Proteomes:UP000189701, ECO:0000313|RefSeq:XP_009802074.1};
RN [1] {ECO:0000313|Proteomes:UP000189701}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23773524; DOI=10.1186/gb-2013-14-6-r60;
RA Sierro N., Battey J.N., Ouadi S., Bovet L., Goepfert S., Bakaher N.,
RA Peitsch M.C., Ivanov N.V.;
RT "Reference genomes and transcriptomes of Nicotiana sylvestris and Nicotiana
RT tomentosiformis.";
RL Genome Biol. 14:R60.1-R60.17(2013).
RN [2] {ECO:0000313|RefSeq:XP_009802074.1}
RP IDENTIFICATION.
RC TISSUE=Leaf {ECO:0000313|RefSeq:XP_009802074.1};
RG RefSeq;
RL Submitted (AUG-2025) to UniProtKB.
CC -!- SIMILARITY: Belongs to the iron/ascorbate-dependent oxidoreductase
CC family. {ECO:0000256|ARBA:ARBA00008056, ECO:0000256|RuleBase:RU003682}.
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DR RefSeq; XP_009802074.1; XM_009803772.1.
DR AlphaFoldDB; A0A1U7YS76; -.
DR STRING; 4096.A0A1U7YS76; -.
DR GeneID; 104247695; -.
DR KEGG; nsy:104247695; -.
DR eggNOG; KOG0143; Eukaryota.
DR OrthoDB; 1274583at2759; -.
DR Proteomes; UP000189701; Unplaced.
DR GO; GO:0016706; F:2-oxoglutarate-dependent dioxygenase activity; IEA:UniProtKB-ARBA.
DR GO; GO:0031418; F:L-ascorbic acid binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0009805; P:coumarin biosynthetic process; IEA:UniProtKB-ARBA.
DR GO; GO:0002238; P:response to molecule of fungal origin; IEA:UniProtKB-ARBA.
DR FunFam; 2.60.120.330:FF:000005; 1-aminocyclopropane-1-carboxylate oxidase homolog 1; 1.
DR Gene3D; 2.60.120.330; B-lactam Antibiotic, Isopenicillin N Synthase, Chain; 1.
DR InterPro; IPR026992; DIOX_N.
DR InterPro; IPR044861; IPNS-like_FE2OG_OXY.
DR InterPro; IPR027443; IPNS-like_sf.
DR InterPro; IPR005123; Oxoglu/Fe-dep_dioxygenase_dom.
DR PANTHER; PTHR10209:SF792; 1-AMINOCYCLOPROPANE-1-CARBOXYLATE OXIDASE HOMOLOG; 1.
DR PANTHER; PTHR10209; OXIDOREDUCTASE, 2OG-FE II OXYGENASE FAMILY PROTEIN; 1.
DR Pfam; PF03171; 2OG-FeII_Oxy; 1.
DR Pfam; PF14226; DIOX_N; 1.
DR SUPFAM; SSF51197; Clavaminate synthase-like; 1.
DR PROSITE; PS51471; FE2OG_OXY; 1.
PE 3: Inferred from homology;
KW Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|RuleBase:RU003682};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU003682};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|RuleBase:RU003682};
KW Reference proteome {ECO:0000313|Proteomes:UP000189701};
KW Vitamin C {ECO:0000256|ARBA:ARBA00022896}.
FT DOMAIN 221..321
FT /note="Fe2OG dioxygenase"
FT /evidence="ECO:0000259|PROSITE:PS51471"
SQ SEQUENCE 374 AA; 42150 MW; 909F4C473727C7D6 CRC64;
MVFSGGEEHQ GTFQQNYDKQ SELKAFDDTK AGVKGVVDAG ITKVPRMFIH PQESIHNSSN
STEKNFIFPV IDLEGIDHPI KHKEIVDKVR DASETWGFFQ VVNHGIPLPV LEEMLQGARR
FFEQDIEIKR QYYTRDNTKK VAHVSNFDLY STSVPAASWR DSLYCVMAPN PPDPEELPVA
CREILMDFSE HMMKLGYSLL ELLSEGLGLN SCHLKDMNIA EGLSIGHHYY PACPQPELTI
GTRKHSDCVF MTVLLQDDIG GLQVLHQNQW IDVPPLSGAL VVNIGDMLQL ILNDKYLSVE
HRVLSNKVGP RISVPSFFST GAFPSSRIYG PIKELLSECN PPKYRATTVK EYTDFFRSKG
FDGTSALQHY KILS
//
