ID A0A1U8IJL2_GOSHI Unreviewed; 636 AA.
AC A0A1U8IJL2;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 28-JAN-2026, entry version 35.
DE SubName: Full=DNA repair protein RadA isoform X1 {ECO:0000313|RefSeq:XP_016678285.1};
GN Name=LOC107897358 {ECO:0000313|RefSeq:XP_016678285.1};
OS Gossypium hirsutum (Upland cotton) (Gossypium mexicanum).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Malvales; Malvaceae; Malvoideae; Gossypium.
OX NCBI_TaxID=3635 {ECO:0000313|Proteomes:UP000818029, ECO:0000313|RefSeq:XP_016678285.1};
RN [1] {ECO:0000313|Proteomes:UP000818029}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. TM-1 {ECO:0000313|Proteomes:UP000818029};
RX PubMed=32313247; DOI=10.1038/s41588-020-0614-5;
RA Chen Z.J., Sreedasyam A., Ando A., Song Q., De Santiago L.M.,
RA Hulse-Kemp A.M., Ding M., Ye W., Kirkbride R.C., Jenkins J., Plott C.,
RA Lovell J., Lin Y.M., Vaughn R., Liu B., Simpson S., Scheffler B.E., Wen L.,
RA Saski C.A., Grover C.E., Hu G., Conover J.L., Carlson J.W., Shu S.,
RA Boston L.B., Williams M., Peterson D.G., McGee K., Jones D.C., Wendel J.F.,
RA Stelly D.M., Grimwood J., Schmutz J.;
RT "Genomic diversifications of five Gossypium allopolyploid species and their
RT impact on cotton improvement.";
RL Nat. Genet. 52:525-533(2020).
RN [2] {ECO:0000313|RefSeq:XP_016678285.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (AUG-2025) to UniProtKB.
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DR RefSeq; XP_016678285.1; XM_016822796.2.
DR AlphaFoldDB; A0A1U8IJL2; -.
DR SMR; A0A1U8IJL2; -.
DR STRING; 3635.A0A1U8IJL2; -.
DR PaxDb; 3635-A0A1U8IJL2; -.
DR GeneID; 107897358; -.
DR KEGG; ghi:107897358; -.
DR OrthoDB; 41505at2759; -.
DR Proteomes; UP000818029; Chromosome A10.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000725; P:recombinational repair; IBA:GO_Central.
DR CDD; cd01121; RadA_SMS_N; 1.
DR FunFam; 3.40.50.300:FF:000050; DNA repair protein RadA; 1.
DR FunFam; 3.30.230.10:FF:000053; DNA repair protein radA isogeny; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR004504; DNA_repair_RadA.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR020588; RecA_ATP-bd.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR NCBIfam; TIGR00416; sms; 1.
DR PANTHER; PTHR32472; DNA REPAIR PROTEIN RADA; 1.
DR PANTHER; PTHR32472:SF10; DNA REPAIR PROTEIN RADA-LIKE PROTEIN; 1.
DR Pfam; PF13481; AAA_25; 1.
DR Pfam; PF13541; ChlI; 1.
DR PRINTS; PR01874; DNAREPAIRADA.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS50162; RECA_2; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000818029};
KW Stress response {ECO:0000256|ARBA:ARBA00023016}.
FT DOMAIN 238..392
FT /note="RecA family profile 1"
FT /evidence="ECO:0000259|PROSITE:PS50162"
FT REGION 67..95
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 636 AA; 68840 MW; 082B4B557F7AE51D CRC64;
MQIIEMKVLR SIYYTHTHFL HRNLSRTPVS LSLFSRHFHS SNPRFSLNSL ETDGTQRAPH
AWTAYEGLTP DLSTPTNRHK GITQGNESAS GDETDADFET HRTYGKAKNA NLSDGDKTQM
AKNARYIPNE NTDGMSRKKA FSVNGLGLGD IVGNKKKGKS RVKWVCENCG YSDGQWWGVC
RSCDFSGTMK RFSEVETKNR GLEFSETLAR SWLPKDTGDV EPVKLIDVNS GVKKTDYRIP
LFGPFGSEVA RVLGGGLVPG SLVLIGGDPG VGKSTLLLQM AALIAEGHDS GQPTCVVYVS
GEESVEQISS RAERMKIGAN ELYLYAGTEI EDILTKIQSL SPRALIVDSI QTVYLKEITG
SAGGLSQVRE CTSALLRFAK KTNIPVLLAG HVTKSGDIAG PRVLEHIVDA VLYLEGEKCS
SHRLLRSVKN RFGSIDELGI FEMSQLGLQV VLNPSEMFLS DQNSDSEFLA GLAVAVIMDG
SRAFLIEIQA LCVSSSTVSR HVNGIQASRA DMLISVLAKQ AGLKIQENAV FLNVVSGVSL
TETAGDLAIA ASICSSFLEF PIPSGVAFIG EIGLGGELRM VSRMDKRVST VAKLGYKKCI
VPMSAKKSLA TLDLGELEII GCNDLKGVIN TVFTKN
//
