ID A0A1U8KMW5_GOSHI Unreviewed; 798 AA.
AC A0A1U8KMW5;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 08-OCT-2025, sequence version 2.
DT 28-JAN-2026, entry version 33.
DE SubName: Full=Phosphate transporter PHO1 homolog 3 {ECO:0000313|RefSeq:XP_016703821.2};
GN Name=LOC107918749 {ECO:0000313|RefSeq:XP_016703821.2};
OS Gossypium hirsutum (Upland cotton) (Gossypium mexicanum).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Malvales; Malvaceae; Malvoideae; Gossypium.
OX NCBI_TaxID=3635 {ECO:0000313|Proteomes:UP000818029, ECO:0000313|RefSeq:XP_016703821.2};
RN [1] {ECO:0000313|Proteomes:UP000818029}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. TM-1 {ECO:0000313|Proteomes:UP000818029};
RX PubMed=32313247; DOI=10.1038/s41588-020-0614-5;
RA Chen Z.J., Sreedasyam A., Ando A., Song Q., De Santiago L.M.,
RA Hulse-Kemp A.M., Ding M., Ye W., Kirkbride R.C., Jenkins J., Plott C.,
RA Lovell J., Lin Y.M., Vaughn R., Liu B., Simpson S., Scheffler B.E., Wen L.,
RA Saski C.A., Grover C.E., Hu G., Conover J.L., Carlson J.W., Shu S.,
RA Boston L.B., Williams M., Peterson D.G., McGee K., Jones D.C., Wendel J.F.,
RA Stelly D.M., Grimwood J., Schmutz J.;
RT "Genomic diversifications of five Gossypium allopolyploid species and their
RT impact on cotton improvement.";
RL Nat. Genet. 52:525-533(2020).
RN [2] {ECO:0000313|RefSeq:XP_016703821.2}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (AUG-2025) to UniProtKB.
CC -!- FUNCTION: May transport inorganic phosphate (Pi).
CC {ECO:0000256|ARBA:ARBA00043939}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
CC -!- SIMILARITY: Belongs to the SYG1 (TC 2.A.94) family.
CC {ECO:0000256|ARBA:ARBA00009665}.
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DR RefSeq; XP_016703821.2; XM_016848332.2.
DR AlphaFoldDB; A0A1U8KMW5; -.
DR SMR; A0A1U8KMW5; -.
DR STRING; 3635.A0A1U8KMW5; -.
DR PaxDb; 3635-A0A1U8KMW5; -.
DR GeneID; 107918749; -.
DR KEGG; ghi:107918749; -.
DR Proteomes; UP000818029; Chromosome A12.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005802; C:trans-Golgi network; IBA:GO_Central.
DR GO; GO:0000822; F:inositol hexakisphosphate binding; IBA:GO_Central.
DR GO; GO:0005315; F:phosphate transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0016036; P:cellular response to phosphate starvation; IBA:GO_Central.
DR GO; GO:0006817; P:phosphate ion transport; IBA:GO_Central.
DR CDD; cd14476; SPX_PHO1_like; 1.
DR InterPro; IPR004342; EXS_C.
DR InterPro; IPR034092; PHO1_SPX.
DR InterPro; IPR004331; SPX_dom.
DR PANTHER; PTHR10783:SF4; PHOSPHATE TRANSPORTER PHO1 HOMOLOG 3; 1.
DR PANTHER; PTHR10783; XENOTROPIC AND POLYTROPIC RETROVIRUS RECEPTOR 1-RELATED; 1.
DR Pfam; PF03124; EXS; 1.
DR Pfam; PF03105; SPX; 1.
DR PROSITE; PS51380; EXS; 1.
DR PROSITE; PS51382; SPX; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Phosphate transport {ECO:0000256|ARBA:ARBA00022592};
KW Reference proteome {ECO:0000313|Proteomes:UP000818029};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 394..416
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 436..457
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 477..498
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 518..537
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 544..561
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 606..623
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 643..660
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 666..692
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 713..733
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..343
FT /note="SPX"
FT /evidence="ECO:0000259|PROSITE:PS51382"
FT DOMAIN 602..796
FT /note="EXS"
FT /evidence="ECO:0000259|PROSITE:PS51380"
FT REGION 210..246
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 210..236
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 798 AA; 92601 MW; F2A2BC16EFD9368B CRC64;
MKFGKEFASQ MVPEWQGAYM DYDYLKTLLK DIHTFNQRTK QQSIPHGLKR SLSMYRAFSG
LLIHRHSQHP PTSPPSPDVE EQPILVNSVN RNGSHKVETT FLMQGDKGGE YELVYFRRLD
DEFNKVDKFY KSKVAEVTQE AEVLNKQMDA LIAFRIKVEN PHGWSWQDQS GDLTRLASDV
AMSTATLAAT IPAGARASGR RSVEHMEIIE EGPSVHDDSD EDKKDTVKKD SGEQNIEKPV
GSKFKKHKPA PLQILDRVKM NNTLATPRST IKVFLNAPKQ SDLKFDRENL KRVENKLKRA
FVEFYQKLLL LKSYSFLNTL AFSKIMKKYD KIASRNASES YMNMVDCSYL GSSEEVTKLM
ERVEATFIKH FANSNRSKGM NVLRPKARKQ RHTTTFYTGF FAGCTAALII ALILVIRARH
ILGHDGTDQY METMFPLYSL FGFIVLHTVM YAGNVYFWRR YRVNYAFIFG FKQGTELGYR
EVLLVSFGLA VMSLGSALSN LDMEMDPKTN DYKAFTEIVP LILVVVVFII LFFPFNILYR
SSRFFFLTCL FHSILAPLYK VRLPDFFLAD QLTSQVQAFR SLEFYVCYYG WGDFRHRENS
CKTNDVFNTF SFIVAVIPFW SRLLQCLRRF FEEKDTLQGY NGIKYFITIV ALCLRTAYSL
NKGLGWEILA LVFSVAAAIV GTYWDLVYDW GLLQRHSRNR WLRDKLLVPR KSVYFGAMVL
NVLLRFAWLQ TVFNFKIFDL HRQTVTTMVA SLEIIRRGMW NFFRLENEHL NNVGKYRAFK
SVPLPFNYDE DEDEDKNE
//
