ID A0A1U8NAR6_GOSHI Unreviewed; 673 AA.
AC A0A1U8NAR6;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 08-OCT-2025, sequence version 2.
DT 28-JAN-2026, entry version 33.
DE SubName: Full=Inorganic pyrophosphatase TTM2 isoform X1 {ECO:0000313|RefSeq:XP_016736105.2};
GN Name=LOC107946344 {ECO:0000313|RefSeq:XP_016736105.2};
OS Gossypium hirsutum (Upland cotton) (Gossypium mexicanum).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Malvales; Malvaceae; Malvoideae; Gossypium.
OX NCBI_TaxID=3635 {ECO:0000313|Proteomes:UP000818029, ECO:0000313|RefSeq:XP_016736105.2};
RN [1] {ECO:0000313|Proteomes:UP000818029}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. TM-1 {ECO:0000313|Proteomes:UP000818029};
RX PubMed=32313247; DOI=10.1038/s41588-020-0614-5;
RA Chen Z.J., Sreedasyam A., Ando A., Song Q., De Santiago L.M.,
RA Hulse-Kemp A.M., Ding M., Ye W., Kirkbride R.C., Jenkins J., Plott C.,
RA Lovell J., Lin Y.M., Vaughn R., Liu B., Simpson S., Scheffler B.E., Wen L.,
RA Saski C.A., Grover C.E., Hu G., Conover J.L., Carlson J.W., Shu S.,
RA Boston L.B., Williams M., Peterson D.G., McGee K., Jones D.C., Wendel J.F.,
RA Stelly D.M., Grimwood J., Schmutz J.;
RT "Genomic diversifications of five Gossypium allopolyploid species and their
RT impact on cotton improvement.";
RL Nat. Genet. 52:525-533(2020).
RN [2] {ECO:0000313|RefSeq:XP_016736105.2}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (AUG-2025) to UniProtKB.
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DR RefSeq; XP_016736105.2; XM_016880616.2.
DR AlphaFoldDB; A0A1U8NAR6; -.
DR STRING; 3635.A0A1U8NAR6; -.
DR PaxDb; 3635-A0A1U8NAR6; -.
DR GeneID; 107946344; -.
DR KEGG; ghi:107946344; -.
DR Proteomes; UP000818029; Chromosome D12.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016301; F:kinase activity; IEA:InterPro.
DR GO; GO:0016462; F:pyrophosphatase activity; IBA:GO_Central.
DR CDD; cd02028; UMPK_like; 1.
DR Gene3D; 2.40.320.10; Hypothetical Protein Pfu-838710-001; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR033469; CYTH-like_dom_sf.
DR InterPro; IPR023577; CYTH_domain.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR006083; PRK/URK.
DR PANTHER; PTHR10285; URIDINE KINASE; 1.
DR Pfam; PF01928; CYTH; 1.
DR Pfam; PF00485; PRK; 1.
DR PRINTS; PR00988; URIDINKINASE.
DR SUPFAM; SSF55154; CYTH-like phosphatases; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51707; CYTH; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000818029};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 644..665
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 261..419
FT /note="CYTH"
FT /evidence="ECO:0000259|PROSITE:PS51707"
FT COILED 510..537
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 673 AA; 75835 MW; A74D976A6F320204 CRC64;
MPEVAVIFSM AQDASGIETC HKKPGLLKDQ VPLVKRKDID RHEIVSIQDP LSFEQGFFIV
IRACQSLAQK NDGIVLVGLA GPSGAGKTVF TEKMLNFMPN IAIITMDNYN DSSRIVDGNF
DDPRLTDYDM LLQNVHDLKE GKDVQVPIYD FKTSSRTGYR TLEVPISRIV IIEGIYALSE
KLRPMLDLRV SVTGGVHFDL VKRVLRDIQR AGQEPEEIIH QISETVYPMY KAFIEPDLQT
AHIKIINKFN PFTGFQSPTY ILKSARKFTV DQIKSVVSKA HMETEEQTYD IYLLPPGEDP
DSCQSYLRMQ NKDGKYSLMF EEWVTDIPFV ISPRITFEVS VRLLGGLMAL GYTISAILKR
NSHVFSDDNV CVKIDWLEQL NRQYLQVQGR DRSVVKDVAE RLGLEGSYIP RTYIEQIRLE
KLVNEVMALP EDLKTKLSLD EDLVSSPKEA LLGASMDMVA LRNMHLRSGM SLSYSTQREK
YISNFAGYSV NNQRFGQRNS ESALANKGVI NQLSEQISSL NDRMDEFTTR VEELNSKLTI
KRRTSIQQNL AFRAESCKGS ASTSYFINGL GNGSIITNSS SSSQLAKDSP LMEEQISTVA
EGQRRIIYQL DSLSNLLHER LGERSEQANT RRKYMVAGAE PIKVPLILTT LTIGGLGIFL
FRGFLCNSSS QVF
//
