ID A0A1V1UY85_9CAUL Unreviewed; 972 AA.
AC A0A1V1UY85;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 18-JUN-2025, entry version 25.
DE SubName: Full=Na(+)/H(+) antiporter subunit A {ECO:0000313|EMBL:GAW40833.1};
GN Name=mrpA {ECO:0000313|EMBL:GAW40833.1};
GN ORFNames=SH203_01233 {ECO:0000313|EMBL:GAW40833.1};
OS Brevundimonas sp. SH203.
OC Bacteria; Pseudomonadati; Pseudomonadota; Alphaproteobacteria;
OC Caulobacterales; Caulobacteraceae; Brevundimonas.
OX NCBI_TaxID=345167 {ECO:0000313|EMBL:GAW40833.1, ECO:0000313|Proteomes:UP000195546};
RN [1] {ECO:0000313|EMBL:GAW40833.1, ECO:0000313|Proteomes:UP000195546}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SH203 {ECO:0000313|EMBL:GAW40833.1,
RC ECO:0000313|Proteomes:UP000195546};
RA Suzuki T., Kikuchi M., Habu N., Konno N.;
RT "Draft Genome Sequence of Brevundimonas sp. SH203, producing Cellouronate
RT (beta-1,4-linked polyglucuronate) lyase.";
RL Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|RuleBase:RU000320}; Multi-pass membrane protein
CC {ECO:0000256|RuleBase:RU000320}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GAW40833.1}.
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DR EMBL; BDMM01000002; GAW40833.1; -; Genomic_DNA.
DR RefSeq; WP_087119968.1; NZ_BDMM01000002.1.
DR AlphaFoldDB; A0A1V1UY85; -.
DR OrthoDB; 9811798at2; -.
DR Proteomes; UP000195546; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR GO; GO:0006811; P:monoatomic ion transport; IEA:UniProtKB-KW.
DR InterPro; IPR050616; CPA3_Na-H_Antiporter_A.
DR InterPro; IPR007182; MnhB.
DR InterPro; IPR025383; MrpA_C/MbhD.
DR InterPro; IPR046806; MrpA_C/MbhE.
DR InterPro; IPR001750; ND/Mrp_TM.
DR InterPro; IPR001516; Proton_antipo_N.
DR NCBIfam; NF009288; PRK12648.1; 1.
DR PANTHER; PTHR43373; NA(+)/H(+) ANTIPORTER SUBUNIT; 1.
DR PANTHER; PTHR43373:SF1; NA(+)_H(+) ANTIPORTER SUBUNIT A; 1.
DR Pfam; PF13244; MbhD; 1.
DR Pfam; PF20501; MbhE; 1.
DR Pfam; PF04039; MnhB; 1.
DR Pfam; PF00361; Proton_antipo_M; 1.
DR Pfam; PF00662; Proton_antipo_N; 1.
DR PRINTS; PR01434; NADHDHGNASE5.
PE 4: Predicted;
KW Antiport {ECO:0000256|ARBA:ARBA00022449};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000195546};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000320};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 6..24
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 31..54
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 74..98
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 110..128
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 166..189
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 209..234
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 246..268
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 274..295
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 302..321
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 371..393
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 413..431
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 463..483
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 503..527
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 580..600
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 612..630
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 637..657
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 663..685
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 706..727
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 765..783
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 827..845
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 851..874
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 886..911
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 931..954
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 68..114
FT /note="NADH-Ubiquinone oxidoreductase (complex I) chain 5
FT N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00662"
FT DOMAIN 130..405
FT /note="NADH:quinone oxidoreductase/Mrp antiporter
FT transmembrane"
FT /evidence="ECO:0000259|Pfam:PF00361"
FT DOMAIN 623..686
FT /note="MrpA C-terminal/MbhD"
FT /evidence="ECO:0000259|Pfam:PF13244"
FT DOMAIN 703..800
FT /note="MrpA C-terminal/MbhE"
FT /evidence="ECO:0000259|Pfam:PF20501"
FT DOMAIN 824..947
FT /note="Na+/H+ antiporter MnhB subunit-related protein"
FT /evidence="ECO:0000259|Pfam:PF04039"
FT REGION 792..814
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 795..805
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 972 AA; 104661 MW; E61B215B6DFE1E80 CRC64;
MSISFLLLII LILPFMGAIA AAGLPRHART AAAILSWIVA LISLGCLAAL WPMFQDGETL
KFEIPWLPSL GVNLALRLDG LSWLFSALIL GIGALVVLYA RYYMSPKDPV PRFFSFLLAF
MGAMQGVVLS GNLIQLVVFW ELTSLFSFLL IGYWHQNPAA REGSRMALTV TATGGIALLV
GMILIGRIVG SYDLDVVLAS RKAIQDSPLY LPALLLLLAG AMTKSAQFPF HFWLPRAMAA
PTPVSAYLHS ATMVKAGVFL LIRFWPVFAG TESWYLIVGG MGLATLLLGA WCAIFQHDLK
GLLAYSTISH LGLIVLLLGL GSPLGCIAAI FHTVNHATFK ASLFMAAGII DHEAGTRDMR
KLSGLFRFMP FTATLAMVAA AAMAGVPLLN GFLSKEMFLA EAVASVNTHG LNLLLPALAT
LASAFSVLYS LRFIHTTFFG PPPTELDRTP HEPPAWMRRP VEVLVGLCLV VGVFPAVTVG
PFLKSAAVSV LGFNLPYYSL ALWHGFNLPL VLSLIALGGG VALYVAFGSR INANPRGGPW
GWKRLNGGWL FEKTMTGLFK GSDALVRLFG ATRQQPQLRA IVLVALLAGG LAATGGGLVV
QPILPTPSLA DWAFAGLWLI GAGCAVAAAW QAKYHRLAAV VLMGGAGLAS CLSFVWLSAP
DLAVTQLLVE VVTTVLLLLG LRWLPKRLEF IRLPPAMEKR SRVRRRIDLI IAAAVGTALA
AIAYAVMTRP SVEGISRFFV EHAYKDAGGR NIVNVILVDF RAFDTFGEIT VLGVVGLTVF
ALLRRFRPAD DTLSGPKQQR VQNASDRAHE SRSEGDTLKE TMLIPRVVMR WLFPFIILLA
VHLFLRGHDL PGGGFAAGVA LSIAFVLQYM ASGARWVEER LAIRPIVWIG AGLVIAALSG
VGSWLFGYPF LTSWFQYADL PILGRVPLAS AVLFDLGVVV LVVGATVLTL VALAHQSLRK
PKQRDAEEGE PS
//
