ID A0A1V4A2C8_9ACTN Unreviewed; 310 AA.
AC A0A1V4A2C8;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 02-APR-2025, entry version 28.
DE SubName: Full=RNA polymerase subunit sigma {ECO:0000313|EMBL:OON72996.1};
GN ORFNames=B1H18_27950 {ECO:0000313|EMBL:OON72996.1};
OS Streptomyces tsukubensis.
OC Bacteria; Bacillati; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=83656 {ECO:0000313|EMBL:OON72996.1, ECO:0000313|Proteomes:UP000190539};
RN [1] {ECO:0000313|EMBL:OON72996.1, ECO:0000313|Proteomes:UP000190539}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=F601 {ECO:0000313|EMBL:OON72996.1,
RC ECO:0000313|Proteomes:UP000190539};
RA Zong G., Zhong C., Fu J., Qin R., Cao G.;
RT "Draft Genome Sequence of Streptomyces tsukubaensis F601, a Producer of the
RT immunosuppressant tacrolimus FK506.";
RL Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OON72996.1}.
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DR EMBL; MVFC01000033; OON72996.1; -; Genomic_DNA.
DR RefSeq; WP_077972634.1; NZ_CP045178.1.
DR AlphaFoldDB; A0A1V4A2C8; -.
DR STRING; 83656.B1H18_27950; -.
DR Proteomes; UP000190539; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0016987; F:sigma factor activity; IEA:UniProtKB-KW.
DR GO; GO:0006352; P:DNA-templated transcription initiation; IEA:InterPro.
DR CDD; cd06171; Sigma70_r4; 1.
DR Gene3D; 1.20.120.1810; -; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 2.
DR InterPro; IPR014284; RNA_pol_sigma-70_dom.
DR InterPro; IPR014322; RNA_pol_sigma-B/F/G.
DR InterPro; IPR000943; RNA_pol_sigma70.
DR InterPro; IPR007627; RNA_pol_sigma70_r2.
DR InterPro; IPR007624; RNA_pol_sigma70_r3.
DR InterPro; IPR007630; RNA_pol_sigma70_r4.
DR InterPro; IPR013325; RNA_pol_sigma_r2.
DR InterPro; IPR013324; RNA_pol_sigma_r3/r4-like.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR NCBIfam; TIGR02980; SigBFG; 1.
DR NCBIfam; TIGR02937; sigma70-ECF; 1.
DR PANTHER; PTHR30385:SF4; RNA POLYMERASE SIGMA-E FACTOR; 1.
DR PANTHER; PTHR30385; SIGMA FACTOR F FLAGELLAR; 1.
DR Pfam; PF04542; Sigma70_r2; 1.
DR Pfam; PF04539; Sigma70_r3; 1.
DR Pfam; PF04545; Sigma70_r4; 1.
DR PRINTS; PR00046; SIGMA70FCT.
DR SUPFAM; SSF88946; Sigma2 domain of RNA polymerase sigma factors; 1.
DR SUPFAM; SSF88659; Sigma3 and sigma4 domains of RNA polymerase sigma factors; 2.
DR PROSITE; PS00715; SIGMA70_1; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Reference proteome {ECO:0000313|Proteomes:UP000190539};
KW Sigma factor {ECO:0000256|ARBA:ARBA00023082};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 113..126
FT /note="RNA polymerase sigma-70"
FT /evidence="ECO:0000259|PROSITE:PS00715"
FT REGION 1..54
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..27
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 310 AA; 34633 MW; 2486ECE2D9DC01A5 CRC64;
MEDTMSPQLD ESHQFWATST LPPQRTGSDL PEAVQSTADL STEPEGLPEI PPFDKVGPLD
ARALSKTLFE RLETLEEGTH EHAYVRNTLV ELNLALVKFA ASRFRSRSEP MEDIIQVGTI
GLIKAIDRFE LTRGVEFPTF AMPTIVGEIK RFFRDTSWSV RVPRRLQELR LDLAKAGDEL
AQQLDRSPTP GELAEKLGIS RDEVVEGMAA SNAYTASSLD AQPEEDDSEG ALADRIGYED
HSLEGIEYIE SLKPMIAELP ARDRQILSLR FVANMTQSEI GEELGISQMH VSRLLSRTLV
RLRKGLTLEE
//
