ID A0A1V4D7B1_9ACTN Unreviewed; 1552 AA.
AC A0A1V4D7B1;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 28-JAN-2026, entry version 33.
DE SubName: Full=Cation-transporting ATPase {ECO:0000313|EMBL:OPF80741.1};
GN ORFNames=VT50_0211765 {ECO:0000313|EMBL:OPF80741.1};
OS Streptomyces antioxidans.
OC Bacteria; Bacillati; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1507734 {ECO:0000313|EMBL:OPF80741.1, ECO:0000313|Proteomes:UP000033615};
RN [1] {ECO:0000313|EMBL:OPF80741.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MUSC 164 {ECO:0000313|EMBL:OPF80741.1};
RA Lee L.-H., Ser H.-L.;
RT "Genome sequence of Streptomyces antioxidans MUSC 164.";
RL Submitted (DEC-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + phosphate + H(+); Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216;
CC Evidence={ECO:0000256|ARBA:ARBA00049360};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OPF80741.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; LAKD02000029; OPF80741.1; -; Genomic_DNA.
DR Proteomes; UP000033615; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0005388; F:P-type calcium transporter activity; IEA:TreeGrafter.
DR Gene3D; 3.30.70.100; -; 1.
DR Gene3D; 3.40.1110.10; Calcium-transporting ATPase, cytoplasmic domain N; 1.
DR Gene3D; 2.70.150.10; Calcium-transporting ATPase, cytoplasmic transduction domain A; 1.
DR Gene3D; 1.20.1110.10; Calcium-transporting ATPase, transmembrane domain; 1.
DR Gene3D; 3.40.50.1000; HAD superfamily/HAD-like; 1.
DR InterPro; IPR006068; ATPase_P-typ_cation-transptr_C.
DR InterPro; IPR023299; ATPase_P-typ_cyto_dom_N.
DR InterPro; IPR018303; ATPase_P-typ_P_site.
DR InterPro; IPR023298; ATPase_P-typ_TM_dom_sf.
DR InterPro; IPR008250; ATPase_P-typ_transduc_dom_A_sf.
DR InterPro; IPR059000; ATPase_P-type_domA.
DR InterPro; IPR036412; HAD-like_sf.
DR InterPro; IPR023214; HAD_sf.
DR InterPro; IPR036163; HMA_dom_sf.
DR InterPro; IPR001757; P_typ_ATPase.
DR InterPro; IPR044492; P_typ_ATPase_HD_dom.
DR NCBIfam; TIGR01494; ATPase_P-type; 2.
DR PANTHER; PTHR24093; CATION TRANSPORTING ATPASE; 1.
DR PANTHER; PTHR24093:SF513; CATION-TRANSPORTING ATPASE I-RELATED; 1.
DR Pfam; PF00689; Cation_ATPase_C; 1.
DR Pfam; PF00122; E1-E2_ATPase; 1.
DR Pfam; PF00702; Hydrolase; 1.
DR PRINTS; PR00119; CATATPASE.
DR PRINTS; PR00120; HATPASE.
DR SFLD; SFLDG00002; C1.7:_P-type_atpase_like; 1.
DR SFLD; SFLDS00003; Haloacid_Dehalogenase; 1.
DR SFLD; SFLDF00027; p-type_atpase; 1.
DR SUPFAM; SSF81653; Calcium ATPase, transduction domain A; 1.
DR SUPFAM; SSF81665; Calcium ATPase, transmembrane domain M; 1.
DR SUPFAM; SSF56784; HAD-like; 1.
DR SUPFAM; SSF55008; HMA, heavy metal-associated domain; 1.
DR PROSITE; PS00154; ATPASE_E1_E2; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000033615};
KW Translocase {ECO:0000256|ARBA:ARBA00022967};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 819..916
FT /note="P-type ATPase A"
FT /evidence="ECO:0000259|Pfam:PF00122"
FT DOMAIN 1381..1537
FT /note="Cation-transporting P-type ATPase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00689"
FT REGION 642..665
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1552 AA; 159963 MW; D1A8C6EECED0F524 CRC64;
MLTGLVSAPS RAMNGLRLRL ADLNDILRDT GDRRGGRSMW ARAGRAHVEV RGLTGHGDGH
ERLVRELEDA LRRVAGVNWA GVNAALGQVL VDFDEDRLGP DDVLEVIERV EEARGTDADT
FPAGRPQPPF ASAPATLAAT ALAADCLGLL TAAIRRVAMR PARSPALRLP AVMAELQPRV
RGLLESRFGR AHADTLIGVS NAVVHALTRG EAPLALDALQ RVLQLAEIRG RQAVWERREP
ELVADGDGLP ARSHPPAARP APLPPGPVET CVDHTSLASL AGAGGLLAWT RDPERSAKAL
LATVPKAAAM GREAFAARLG DVLARDGAVP MDGTALRLLD RVSAVLIDSR VLCARRPRLL
SVTTVGDLGE AEAWSAAQSV LDRRTLRELS GEGPWTHGRW RLERSSELPA ALPASPLALT
AELCGEDGRR QARIRIGCEL DPLADALVVA ARSGARRLVV TSHASTDEIA PWADELLPLG
MSLPDTVRRL QLEGHGVLLI SGEDDEALGA ADLGVAVTAR GADRVCWSAD LLCGPGLLHA
WRVLRALEDA RSVSRRSARL SMGGSVLGAL IAAAGTRPAV AGLATSPVYS AAFLAVLGGI
GAARRVERRP APEPRVRGNW HALGARETLS VLRAFRENGT ELPDGSGALR STGSGDPGAA
RASGAVWAAG ARPAHKAAGT AVRTGAPGAA GHGPARFAAL ARNAAPSARF AALTRNAASL
AHAVREELHD PLTPVLALGA AASAAVGSGV DSILVVSVMA GNAVISGAQR LRAERSLRAL
LLSERMNGRL VAWAPAMSLA DGVTADREVF FAGLATAPVR TVATEELRVG DIVALRPSDV
VPADARLLVS DRLELDEAGL TGESGPVAKD PAATPGADLA DRSCMLYQGC TVLAGTGYAV
VVAAGAQTEA GRAAELAGHA TAPVGIEGRL AALTKVALPA TGLGGAAVTL LGLVHGVPVR
EALSTGVAIA VAAVPEGLPL VATVAQSAAA RRLSHRGVLT RSARVLEALG RVDVVCFDKT
GTLTEGRLAV ARVAGYDQEL PTRSALGKRL LRTAARACPE PEGGRALAHA TDQAVIDAAA
AHCEGDGAWR PVSELPFEAN RGFSACLGTR SGRPRLAVKG APEVVLARCA YALSPGAADD
TVPLTPERRS ATERLLHSLA SDGLRVLAVA EARPAASNTP AAEVAELARE LTLLGFIAIA
DTTRPGAAET VKRLTGAGVR VAMVTGDHPT TAVAIARELG IADAEPVLTG AELDTLPEGE
RVERIARTSV FARVSPEHKV RIVQALRQAG QVVAMTGDGV NDAAAIRLAD IGIGLSAHGS
ASARAAADLV LTDPDPTRIL DALREGRALW RSVRDAVAIL VGGNAGEVAF TLLGAAVAGR
APLGTRQLLL VNLLTDMLPA LAVALARARE PKSGEDPLMG GPSSALFGSD LGRILAVRGS
ATALGAAAAW QCGRMTGRAR RASTMGLAAL VGTQLGQTYL TDWHSPLVLI TSAASAAALF
AIVETPVVSH FFGCTPLGPM AWSIVGGCSA AATVAAAVAP RLLFPRRVPL AV
//
