ID A0A1V6Q251_9EURO Unreviewed; 1044 AA.
AC A0A1V6Q251;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 28-JAN-2026, entry version 33.
DE RecName: Full=P-type Na(+) transporter {ECO:0000256|ARBA:ARBA00035029};
DE EC=7.2.2.3 {ECO:0000256|ARBA:ARBA00035029};
GN ORFNames=PENANT_c019G09552 {ECO:0000313|EMBL:OQD82796.1};
OS Penicillium antarcticum.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium.
OX NCBI_TaxID=416450 {ECO:0000313|EMBL:OQD82796.1, ECO:0000313|Proteomes:UP000191672};
RN [1] {ECO:0000313|Proteomes:UP000191672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IBT 31811 {ECO:0000313|Proteomes:UP000191672};
RX PubMed=28368369; DOI=10.1038/nmicrobiol.2017.44;
RA Nielsen J.C., Grijseels S., Prigent S., Ji B., Dainat J., Nielsen K.F.,
RA Frisvad J.C., Workman M., Nielsen J.;
RT "Global analysis of biosynthetic gene clusters reveals vast potential of
RT secondary metabolite production in Penicillium species.";
RL Nat. Microbiol. 2:17044-17044(2017).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=K(+)(in) + ATP + H2O = K(+)(out) + ADP + phosphate + H(+);
CC Xref=Rhea:RHEA:75815, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:29103, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474,
CC ChEBI:CHEBI:456216; Evidence={ECO:0000256|ARBA:ARBA00048599};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Na(+)(in) + ATP + H2O = Na(+)(out) + ADP + phosphate + H(+);
CC Xref=Rhea:RHEA:14633, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:29101, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474,
CC ChEBI:CHEBI:456216; EC=7.2.2.3;
CC Evidence={ECO:0000256|ARBA:ARBA00049499};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:14634;
CC Evidence={ECO:0000256|ARBA:ARBA00049499};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
CC -!- SIMILARITY: Belongs to the cation transport ATPase (P-type) (TC 3.A.3)
CC family. Type IID subfamily. {ECO:0000256|ARBA:ARBA00035017}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OQD82796.1}.
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DR EMBL; MDYN01000019; OQD82796.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1V6Q251; -.
DR STRING; 416450.A0A1V6Q251; -.
DR OrthoDB; 3352408at2759; -.
DR Proteomes; UP000191672; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0008554; F:P-type sodium transporter activity; IEA:UniProtKB-EC.
DR GO; GO:0006813; P:potassium ion transport; IEA:UniProtKB-KW.
DR CDD; cd02086; P-type_ATPase_Na_ENA; 1.
DR FunFam; 2.70.150.10:FF:000016; Calcium-transporting P-type ATPase putative; 1.
DR FunFam; 3.40.50.1000:FF:000001; Phospholipid-transporting ATPase IC; 1.
DR FunFam; 1.20.1110.10:FF:000015; Sodium ion P-type ATPase; 1.
DR FunFam; 1.20.1110.10:FF:000020; Sodium ion P-type ATPase; 1.
DR FunFam; 3.40.1110.10:FF:000039; Sodium P-type ATPase; 1.
DR FunFam; 3.40.50.1000:FF:000047; Sodium P-type ATPase; 1.
DR Gene3D; 3.40.1110.10; Calcium-transporting ATPase, cytoplasmic domain N; 1.
DR Gene3D; 2.70.150.10; Calcium-transporting ATPase, cytoplasmic transduction domain A; 1.
DR Gene3D; 1.20.1110.10; Calcium-transporting ATPase, transmembrane domain; 2.
DR InterPro; IPR006068; ATPase_P-typ_cation-transptr_C.
DR InterPro; IPR004014; ATPase_P-typ_cation-transptr_N.
DR InterPro; IPR023299; ATPase_P-typ_cyto_dom_N.
DR InterPro; IPR018303; ATPase_P-typ_P_site.
DR InterPro; IPR023298; ATPase_P-typ_TM_dom_sf.
DR InterPro; IPR008250; ATPase_P-typ_transduc_dom_A_sf.
DR InterPro; IPR059000; ATPase_P-type_domA.
DR InterPro; IPR036412; HAD-like_sf.
DR InterPro; IPR006414; P-type_ATPase_IID.
DR InterPro; IPR001757; P_typ_ATPase.
DR InterPro; IPR044492; P_typ_ATPase_HD_dom.
DR NCBIfam; TIGR01523; ATPase-IID_K-Na; 1.
DR NCBIfam; TIGR01494; ATPase_P-type; 2.
DR PANTHER; PTHR42861; CALCIUM-TRANSPORTING ATPASE; 1.
DR Pfam; PF13246; Cation_ATPase; 1.
DR Pfam; PF00689; Cation_ATPase_C; 1.
DR Pfam; PF00690; Cation_ATPase_N; 1.
DR Pfam; PF00122; E1-E2_ATPase; 1.
DR PRINTS; PR00119; CATATPASE.
DR PRINTS; PR00121; NAKATPASE.
DR SFLD; SFLDG00002; C1.7:_P-type_atpase_like; 1.
DR SFLD; SFLDS00003; Haloacid_Dehalogenase; 1.
DR SFLD; SFLDF00027; p-type_atpase; 1.
DR SMART; SM00831; Cation_ATPase_N; 1.
DR SUPFAM; SSF81653; Calcium ATPase, transduction domain A; 1.
DR SUPFAM; SSF81665; Calcium ATPase, transmembrane domain M; 1.
DR SUPFAM; SSF56784; HAD-like; 1.
DR SUPFAM; SSF81660; Metal cation-transporting ATPase, ATP-binding domain N; 1.
DR PROSITE; PS00154; ATPASE_E1_E2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Potassium {ECO:0000256|ARBA:ARBA00022958};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW Reference proteome {ECO:0000313|Proteomes:UP000191672};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW Translocase {ECO:0000256|ARBA:ARBA00022967};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 75..93
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 99..120
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 297..318
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 324..350
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 866..893
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 913..935
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 964..985
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 997..1016
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 21..95
FT /note="Cation-transporting P-type ATPase N-terminal"
FT /evidence="ECO:0000259|SMART:SM00831"
SQ SEQUENCE 1044 AA; 114632 MW; 595817B052375534 CRC64;
MGEKVTSGTS GPEINELLSK PAHSLPYDIV VQELGSQVDE GLSNDEAARR LQQYGPNKLE
DGEGISVLKI LIGQVANAMM LVLILAMAVS FGIQSWIEGG FICAVIVLNI VVGFFQEYAA
EKTMESLHSL SSPTGIVSRN GQTFSVPSLE IVPGDMVELK TGDTVPADLR LVEAVNFETD
EALLTGESLP VQKEVDSIFK EDTGPGDRLN IAYSSSTVTR GRARGIVVRT GMGTEIGSIA
AALRESDSKV RKVKRGPDGE TKKRWYLQAW TLTGTDAVGR FLGVNVGTSL QRKLSKLAII
LFGVAVLFAI VVMSANLWSS KSEVILYAVG TGLSMIPACL VVVLTITMAV GSKRMVERHV
IVRKLDSLEA LGSVTNICSD KTGTLTQGKM VVRKSWVPAL GTYSVGSSNE PFNPTLGDVT
FSSVAPENHD AEKDGGPFDC QDLLCPELED FLNVASMANL AHVYLSEENE WHARGEPTEI
AIEVFASRFD WNRDRWTKGS EPTWRQKAEF PFDSTVKKMS VLYSTLANGE EKNMVFSKGA
VERILDASTS IVWEKGSAPI ALTDDHRQTI LRNMDELASL GLRVLALAQR PFDQSTRVLE
GSNLERDEVE KNLQFLGLVG IYDPPRPETA GAVAACYRAG ISVHMVTGDH PATAKAIAQL
VGIIPANLSE VSAEVEKAMV LTASEFDKMT DEEVDALPIL PRVIARCAPQ TKVRMIDALH
RRGASVAMTG DGVNDSPSLK HSDVGIAMGK AGSDVAKDVS DIILTDDNFA SILNAVEEGR
RIFDNIQKFV LHLLSENIAQ ACTLLIGLAF KDLDGQSVFP LSPVEIIWVI MITSGMPDMG
LGMEVAAPDI MDRPPHSKQG IFTWEVVIDI LAYGLWTSAL CLSSFSLVMW GFGNGNLGRG
CNREFSEECE LVFKARATTF VCLTWFALFL AWEMVNMRRS FFRMQPKSKK YFTQWAHDVW
RNQFLFWSIL AGFVTVVPIL YIPVINDVVF KHKGITWEWA IVVVETLLFF LGVETWKWGK
RVFFRRMGRQ QHKDAFQQQA GSQA
//
