ID A0A1V6TVK1_9EURO Unreviewed; 768 AA.
AC A0A1V6TVK1;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 05-FEB-2025, entry version 27.
DE RecName: Full=Anaphase-promoting complex subunit 5 {ECO:0000256|ARBA:ARBA00016066};
DE AltName: Full=Cyclosome subunit 5 {ECO:0000256|ARBA:ARBA00031069};
GN ORFNames=PENSTE_c002G05316 {ECO:0000313|EMBL:OQE29573.1};
OS Penicillium steckii.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium.
OX NCBI_TaxID=303698 {ECO:0000313|EMBL:OQE29573.1, ECO:0000313|Proteomes:UP000191285};
RN [1] {ECO:0000313|Proteomes:UP000191285}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IBT 24891 {ECO:0000313|Proteomes:UP000191285};
RX PubMed=28368369; DOI=10.1038/nmicrobiol.2017.44;
RA Nielsen J.C., Grijseels S., Prigent S., Ji B., Dainat J., Nielsen K.F.,
RA Frisvad J.C., Workman M., Nielsen J.;
RT "Global analysis of biosynthetic gene clusters reveals vast potential of
RT secondary metabolite production in Penicillium species.";
RL Nat. Microbiol. 2:17044-17044(2017).
CC -!- FUNCTION: Component of the anaphase promoting complex/cyclosome
CC (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls
CC progression through mitosis and the G1 phase of the cell cycle. The
CC APC/C complex acts by mediating ubiquitination and subsequent
CC degradation of target proteins: it mainly mediates the formation of
CC 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the
CC formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. The
CC APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked
CC branched ubiquitin chains on target proteins.
CC {ECO:0000256|ARBA:ARBA00045696}.
CC -!- SIMILARITY: Belongs to the APC5 family.
CC {ECO:0000256|ARBA:ARBA00007450}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OQE29573.1}.
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DR EMBL; MLKD01000002; OQE29573.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1V6TVK1; -.
DR STRING; 303698.A0A1V6TVK1; -.
DR OrthoDB; 2504561at2759; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000191285; Unassembled WGS sequence.
DR GO; GO:0005680; C:anaphase-promoting complex; IEA:InterPro.
DR GO; GO:0031145; P:anaphase-promoting complex-dependent catabolic process; IEA:TreeGrafter.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0045842; P:positive regulation of mitotic metaphase/anaphase transition; IEA:TreeGrafter.
DR GO; GO:0070979; P:protein K11-linked ubiquitination; IEA:TreeGrafter.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR037679; Apc5.
DR InterPro; IPR026000; Apc5_dom.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR12830; ANAPHASE-PROMOTING COMPLEX SUBUNIT 5; 1.
DR PANTHER; PTHR12830:SF9; ANAPHASE-PROMOTING COMPLEX SUBUNIT 5; 1.
DR Pfam; PF12862; ANAPC5; 1.
DR SUPFAM; SSF48452; TPR-like; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Cell division {ECO:0000256|ARBA:ARBA00022618};
KW Mitosis {ECO:0000256|ARBA:ARBA00022776};
KW Reference proteome {ECO:0000313|Proteomes:UP000191285};
KW Signal {ECO:0000256|SAM:SignalP};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..768
FT /note="Anaphase-promoting complex subunit 5"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5012325235"
FT DOMAIN 264..354
FT /note="Anaphase-promoting complex subunit 5"
FT /evidence="ECO:0000259|Pfam:PF12862"
SQ SEQUENCE 768 AA; 87984 MW; 8C4249998D8BED11 CRC64;
MARYLTPWRI SLLCLITVYT DGVVPNSSAI HVLSFLTAGL FPLDPADKQW EKHYLPGIEE
LEETLSHHES SIPGRTLWDL FLKKIWSLDS LDALEELMND VLPSLLSKTR EQLIHDRDNG
IDPEEEGMRL SRSSPLGVFI RRACLEYTRL QFHDSVRLWT GFVKYRLPTY HMWARRNPSD
EQSPVDVNLA MNGLDTNSYL SQVVYGNFEE EAQEEGTVSV KDAERLVEFQ VGELQRLGGR
VPDEMRAQLK HIMTSESSVP VLMYYLEYLD AWRAGDYTSA FDNLHRYFDY TMHSNVDRSA
YQFALLNLAI IQADFECFSE AISAVQEAVA IARESHDMNC LNFCMSWLYH FGKAFPEQMR
EVQNSGMLGN EKEGLAFLKA KSKETDMWSL LSTTLVSEAK LEMQQGESLA SIIECFVRAS
HVNMTKSLST STGTHMQLQS IMYARIGATH LSWLDTEVFR ECYAEGSPYD DFVRITFRNC
QILAQKGNYK ESFSRMNKVE PERLRAFRYN NSWTYYSGLL QLRRQICRDD KVAVEHILSQ
LRAVQLLEFD MRLLLAFHTI EFTIRQGDYG RALRMVEQAA HSMQPENFDV HSQIKLLCLK
ARILEKSGHP QRGFSLAMRA ASIAHRSKIL FDLWESICTL AAVLLSLREF EAAVELVESI
MPQILESEDF ALIARAYSLL VDANMGIAGE LWSTLGRESL PARKEYVSRA LGYIDSAYDS
YEEIEDLLGQ TEMMAKKATV MHLTGDPVLA NDYAAKYLDL RRRRGAEV
//
