ID A0A1V9ZEP9_ACHHY Unreviewed; 354 AA.
AC A0A1V9ZEP9;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 28-JAN-2026, entry version 23.
DE RecName: Full=Niemann-Pick C1 N-terminal domain-containing protein {ECO:0000259|Pfam:PF16414};
GN ORFNames=ACHHYP_15780 {ECO:0000313|EMBL:OQR96469.1};
OS Achlya hypogyna (Oomycete) (Protoachlya hypogyna).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Saprolegniomycetes;
OC Saprolegniales; Achlyaceae; Achlya.
OX NCBI_TaxID=1202772 {ECO:0000313|EMBL:OQR96469.1, ECO:0000313|Proteomes:UP000243579};
RN [1] {ECO:0000313|EMBL:OQR96469.1, ECO:0000313|Proteomes:UP000243579}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 48635 {ECO:0000313|EMBL:OQR96469.1,
RC ECO:0000313|Proteomes:UP000243579};
RX PubMed=25527045; DOI=10.1093/gbe/evu276;
RA Misner I., Blouin N., Leonard G., Richards T.A., Lane C.E.;
RT "The secreted proteins of Achlya hypogyna and Thraustotheca clavata
RT identify the ancestral oomycete secretome and reveal gene acquisitions by
RT horizontal gene transfer.";
RL Genome Biol. Evol. 7:120-135(2014).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OQR96469.1}.
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DR EMBL; JNBR01000144; OQR96469.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1V9ZEP9; -.
DR STRING; 1202772.A0A1V9ZEP9; -.
DR OrthoDB; 6510177at2759; -.
DR Proteomes; UP000243579; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:TreeGrafter.
DR GO; GO:0032934; F:sterol binding; IEA:TreeGrafter.
DR GO; GO:0015918; P:sterol transport; IEA:TreeGrafter.
DR InterPro; IPR032190; NPC1_N.
DR PANTHER; PTHR45727; NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1; 1.
DR PANTHER; PTHR45727:SF9; SSD DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF16414; NPC1_N; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000243579};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..354
FT /note="Niemann-Pick C1 N-terminal domain-containing
FT protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5011986243"
FT TRANSMEM 324..349
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 69..307
FT /note="Niemann-Pick C1 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16414"
SQ SEQUENCE 354 AA; 37975 MW; B6692246BAB41CBD CRC64;
MAMRGVLTCA LASLWLAGYV RASGCVMTQD CVNPGNIPDY DDCIPKALAN VTAPRPMRGD
GWAIVTGGGA CSADSDCHKG TCVDKSCVCQ NDGVTAGAHC DDFAIQCPEY KESACCSWQQ
NRALADNFKL IATMFGRNTA GGCDACAANM MRMWCGLVCA PNQADFMKMH LPYPSNNRRM
DSMTGKDNVK VLEMNVNLAK PFTCDLFDSC KHTAIASMSD AFKSSLGFLN YQGQTGAVGH
GEYLFFNFGH NASYFNTPAL RCDNYSQVLS PEIFDALPAQ AKLLPSMADP LAAKQCPCGA
CRATCSSSSG ASDHLVLVDN PISFWTGFDG ALVGAVYACI AVFTALLYWK HRND
//
