ID A0A1W0WAV1_HYPEX Unreviewed; 389 AA.
AC A0A1W0WAV1;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 18-JUN-2025, entry version 27.
DE RecName: Full=Proteasomal ubiquitin receptor ADRM1 homolog {ECO:0000256|ARBA:ARBA00070663};
GN ORFNames=BV898_13420 {ECO:0000313|EMBL:OQV12308.1};
OS Hypsibius exemplaris (Freshwater tardigrade).
OC Eukaryota; Metazoa; Ecdysozoa; Tardigrada; Eutardigrada; Parachela;
OC Hypsibioidea; Hypsibiidae; Hypsibius.
OX NCBI_TaxID=2072580 {ECO:0000313|EMBL:OQV12308.1, ECO:0000313|Proteomes:UP000192578};
RN [1] {ECO:0000313|Proteomes:UP000192578}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Z151 {ECO:0000313|Proteomes:UP000192578};
RA Yoshida Y., Koutsovoulos G., Laetsch D., Stevens L., Kumar S., Horikawa D.,
RA Ishino K., Komine S., Tomita M., Blaxter M., Arakawa K.;
RT "Comparative genomics of anhydrobiosis in the tardigrade Hypsibius
RT dujardini.";
RL Submitted (JAN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May function as a proteasomal ubiquitin receptor. May promote
CC the deubiquitinating activity associated with the 26S proteasome.
CC {ECO:0000256|ARBA:ARBA00054744}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the ADRM1 family.
CC {ECO:0000256|ARBA:ARBA00009216}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OQV12308.1}.
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DR EMBL; MTYJ01000148; OQV12308.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1W0WAV1; -.
DR OrthoDB; 340431at2759; -.
DR Proteomes; UP000192578; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0008541; C:proteasome regulatory particle, lid subcomplex; IEA:TreeGrafter.
DR GO; GO:0061133; F:endopeptidase activator activity; IEA:TreeGrafter.
DR GO; GO:0070628; F:proteasome binding; IEA:TreeGrafter.
DR CDD; cd13314; PH_Rpn13; 1.
DR FunFam; 2.30.29.70:FF:000001; Proteasomal ubiquitin receptor ADRM1; 1.
DR Gene3D; 1.10.2020.20; -; 1.
DR Gene3D; 2.30.29.70; Proteasomal ubiquitin receptor Rpn13/ADRM1; 1.
DR InterPro; IPR044867; DEUBAD_dom.
DR InterPro; IPR006773; Rpn13/ADRM1.
DR InterPro; IPR044868; Rpn13/ADRM1_Pru.
DR InterPro; IPR038633; Rpn13/ADRM1_Pru_sf.
DR InterPro; IPR032368; RPN13_DEUBAD.
DR InterPro; IPR038108; RPN13_DEUBAD_sf.
DR PANTHER; PTHR12225; ADHESION REGULATING MOLECULE 1 110 KDA CELL MEMBRANE GLYCOPROTEIN; 1.
DR PANTHER; PTHR12225:SF0; PROTEASOMAL UBIQUITIN RECEPTOR ADRM1; 1.
DR Pfam; PF04683; Rpn13_ADRM1_Pru; 1.
DR Pfam; PF16550; RPN13_C; 1.
DR PROSITE; PS51916; DEUBAD; 1.
DR PROSITE; PS51917; PRU; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Proteasome {ECO:0000256|ARBA:ARBA00022942};
KW Receptor {ECO:0000313|EMBL:OQV12308.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000192578}.
FT DOMAIN 12..126
FT /note="Pru"
FT /evidence="ECO:0000259|PROSITE:PS51917"
FT DOMAIN 252..364
FT /note="DEUBAD"
FT /evidence="ECO:0000259|PROSITE:PS51916"
FT REGION 192..230
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 358..389
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 196..211
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 364..373
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 389 AA; 41252 MW; 9BD31BE213778ED3 CRC64;
MALFGRTTQQ RGASRYLVEF KAGRMTMEGK TVKADPRAGI VYIIKSEEDS LLHFCWKERA
AATAEDDLIV FANDVELKKV PQCKDGRVFV LKVKETGRKL FYWIQEPDAA KDDENLKKVS
EYLAGKTPPR NAAGAGAEGG GLPADLQAMG IDDAALQEML GGVDRNQLMQ LLGMQGGGGA
GNLLQGLRSA VRQEGSAAAA PTATPTSRPP TGNASARGAP RKTATNAAPT SRIQLADLRS
ILGAVAPGAP AATEESAPID WTPALSQSLL LPILSNPAFV ERLTPHLPQD PLVPQTAQEV
MSTIQSPQFQ QAIGAFTSAF ETRQLGPLIQ EFNLGPQAVQ AAQNGDFRAF VKALEKKKEE
EAAPADSAAK PAAVGPSKPN NDDDEMSVD
//
