ID A0A1W6B6N2_9GAMM Unreviewed; 774 AA.
AC A0A1W6B6N2;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 18-JUN-2025, entry version 31.
DE RecName: Full=peptidoglycan glycosyltransferase {ECO:0000256|ARBA:ARBA00044770};
DE EC=2.4.99.28 {ECO:0000256|ARBA:ARBA00044770};
GN ORFNames=B1H58_12495 {ECO:0000313|EMBL:ARJ42760.1};
OS Pantoea alhagi.
OC Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
OC Enterobacterales; Erwiniaceae; Pantoea.
OX NCBI_TaxID=1891675 {ECO:0000313|EMBL:ARJ42760.1, ECO:0000313|Proteomes:UP000192900};
RN [1] {ECO:0000313|EMBL:ARJ42760.1, ECO:0000313|Proteomes:UP000192900}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LTYR-11Z {ECO:0000313|EMBL:ARJ42760.1,
RC ECO:0000313|Proteomes:UP000192900};
RA Zhang L.;
RT "Complete genome sequence of the drought resistance-promoting endophyte
RT Pantoea alhagi LTYR-11Z.";
RL Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-
CC Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-
CC (1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-
CC cis-undecaprenyl diphosphate = [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-
CC D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans,octa-cis-undecaprenyl
CC diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+);
CC Xref=Rhea:RHEA:23708, Rhea:RHEA-COMP:9602, Rhea:RHEA-COMP:9603,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:58405, ChEBI:CHEBI:60033,
CC ChEBI:CHEBI:78435; EC=2.4.99.28;
CC Evidence={ECO:0000256|ARBA:ARBA00049902};
CC -!- PATHWAY: Cell wall biogenesis; peptidoglycan biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004752}.
CC -!- SIMILARITY: In the C-terminal section; belongs to the transpeptidase
CC family. {ECO:0000256|ARBA:ARBA00007090}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the
CC glycosyltransferase 51 family. {ECO:0000256|ARBA:ARBA00007739}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP019706; ARJ42760.1; -; Genomic_DNA.
DR RefSeq; WP_085070714.1; NZ_CP019706.1.
DR AlphaFoldDB; A0A1W6B6N2; -.
DR STRING; 1891675.B1H58_12495; -.
DR KEGG; palh:B1H58_12495; -.
DR OrthoDB; 9766909at2; -.
DR UniPathway; UPA00219; -.
DR Proteomes; UP000192900; Chromosome.
DR GO; GO:0030288; C:outer membrane-bounded periplasmic space; IEA:TreeGrafter.
DR GO; GO:0004180; F:carboxypeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR GO; GO:0008955; F:peptidoglycan glycosyltransferase activity; IEA:InterPro.
DR GO; GO:0009252; P:peptidoglycan biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR FunFam; 1.10.3810.10:FF:000006; Penicillin-binding protein 1C; 1.
DR FunFam; 3.40.710.10:FF:000021; Penicillin-binding protein 1C; 1.
DR Gene3D; 1.10.3810.10; Biosynthetic peptidoglycan transglycosylase-like; 1.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR001264; Glyco_trans_51.
DR InterPro; IPR050396; Glycosyltr_51/Transpeptidase.
DR InterPro; IPR023346; Lysozyme-like_dom_sf.
DR InterPro; IPR011815; PBP_1c.
DR InterPro; IPR009647; PBP_C.
DR InterPro; IPR036950; PBP_transglycosylase.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR NCBIfam; TIGR02073; PBP_1c; 1.
DR NCBIfam; NF008414; PRK11240.1; 1.
DR PANTHER; PTHR32282; BINDING PROTEIN TRANSPEPTIDASE, PUTATIVE-RELATED; 1.
DR PANTHER; PTHR32282:SF15; PENICILLIN-BINDING PROTEIN 1C; 1.
DR Pfam; PF06832; BiPBP_C; 1.
DR Pfam; PF00912; Transgly; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF53955; Lysozyme-like; 1.
PE 3: Inferred from homology;
KW Carboxypeptidase {ECO:0000256|ARBA:ARBA00022645};
KW Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022670};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000192900};
KW Transferase {ECO:0000256|ARBA:ARBA00022676}.
FT DOMAIN 57..222
FT /note="Glycosyl transferase family 51"
FT /evidence="ECO:0000259|Pfam:PF00912"
FT DOMAIN 298..516
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
FT DOMAIN 688..771
FT /note="Penicillin-binding C-terminal"
FT /evidence="ECO:0000259|Pfam:PF06832"
SQ SEQUENCE 774 AA; 84436 MW; 96859D5A26989A64 CRC64;
MKFLLRPVKI VLSGLFILLA LLWLADRLFP LPLQQAAPAR LVVAEDGTPL WRFADKNGIW
RYPVTPEEVS PWYLQALLTY EDRWFWHHPG INPLALLRAA WQDLRGGEIV SGGSTLTMQV
ARLIDPQPRT FAGKLHQAWR ALQLEWHLSK REILTLYLNR APFGGTLEGV GAASWSWLGK
SPAALTRGEA ALLAVLPQAP SRLRPDRWPE RAQAARDKVL LRLADYGVWP RVDVEEIMQE
PVWLAPRQMP QLAPLLARRV LALSKQSKIT TTINTSLQRQ IEALAQGWKG SLPPRTSMAV
LVVDHTTMQV RAWMGSVDLN DESRFGHVDM IGSVRSPGSV LKPFLYGLAL DDGLIAAESL
LQDVPRRFGD YRPGNFDTGF HGPVSASEAL VRSLNLPAVQ LLEAYGPKRL TAALRNAGLT
LRFPAAAEPN LSLILGGTGA RMEEIVAAYG AFARHGQAAR LRLLADDPLI ERPLLSPGAA
WIIRRILAGE AQPQPDAALP LIAPLAWKTG TSYGYRDAWA IGINARYLIG VWVGRPDGTP
VAGQFGAASA IPVLNQVHHL LMASPQLRGA VLPADPRPAS VSALTLCWPG GQPLPAGDSN
CRQRRQSWVL NGTTPPTLLA DGQEGLFGLQ QTVWLNAQGE RVAADCSGAQ ARRVALWPMP
LEPWLLPDER RAQRLPLPSA SCAPALQSIA PPLLLTGIRD GQILHRLPGK SELSLSVTTQ
GGEGMARWWF LNGEVLSAAD GSLTQRLVLN RTGHYQLSVL DAAGQVAAVS FTVE
//
