ID A0A1X6WVP7_9MICO Unreviewed; 596 AA.
AC A0A1X6WVP7;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 28-JAN-2026, entry version 32.
DE RecName: Full=Selenocysteine-specific elongation factor {ECO:0000256|ARBA:ARBA00015953};
DE AltName: Full=SelB translation factor {ECO:0000256|ARBA:ARBA00031615};
GN ORFNames=FM110_03810 {ECO:0000313|EMBL:SLM89534.1};
OS Brachybacterium nesterenkovii.
OC Bacteria; Bacillati; Actinomycetota; Actinomycetes; Micrococcales;
OC Dermabacteraceae; Brachybacterium.
OX NCBI_TaxID=47847 {ECO:0000313|EMBL:SLM89534.1, ECO:0000313|Proteomes:UP000195981};
RN [1] {ECO:0000313|EMBL:SLM89534.1, ECO:0000313|Proteomes:UP000195981}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CIP104813 {ECO:0000313|EMBL:SLM89534.1,
RC ECO:0000313|Proteomes:UP000195981};
RA Peterson S.W.;
RL Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Translation factor necessary for the incorporation of
CC selenocysteine into proteins. It probably replaces EF-Tu for the
CC insertion of selenocysteine directed by the UGA codon. SelB binds GTP
CC and GDP. {ECO:0000256|ARBA:ARBA00025526}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR EMBL; FWFG01000033; SLM89534.1; -; Genomic_DNA.
DR RefSeq; WP_087102816.1; NZ_FWFG01000033.1.
DR AlphaFoldDB; A0A1X6WVP7; -.
DR OrthoDB; 9803139at2; -.
DR Proteomes; UP000195981; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
DR GO; GO:0001514; P:selenocysteine incorporation; IEA:InterPro.
DR CDD; cd04171; SelB; 1.
DR Gene3D; 1.10.10.2770; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR057335; Beta-barrel_SelB.
DR InterPro; IPR050055; EF-Tu_GTPase.
DR InterPro; IPR004161; EFTu-like_2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR015191; SelB_WHD4.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR004535; Transl_elong_SelB.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR NCBIfam; TIGR00475; selB; 1.
DR PANTHER; PTHR43721:SF22; ELONGATION FACTOR TU, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43721; ELONGATION FACTOR TU-RELATED; 1.
DR Pfam; PF25461; Beta-barrel_SelB; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF03144; GTP_EFTU_D2; 1.
DR Pfam; PF09107; WHD_3rd_SelB; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS51722; G_TR_2; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Elongation factor {ECO:0000313|EMBL:SLM89534.1};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00023134};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000195981}.
FT DOMAIN 1..171
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
SQ SEQUENCE 596 AA; 62413 MW; 14269CC23E2645FF CRC64;
MQVVASAGHV DHGKSTLIRA LTGIEPDRWA EERRRGLTID LGFAWTRLPS GREVSFVDVP
GHERFLGNML AGVGPAPVVL FVVAADEGWR AQSDDHRDAV AALGIDRGVV ALTRADRADA
ERIAAVTAQV RAQLAGTGLV DAPVVPVSAI TGEGMDALRE TLDAVLAAAP APDPGAPVRL
WIDRAFSISG AGTVVTGSLI AGTLRTGDRL ELLGAETAAE VQVRGLQSRE SSVEELEPVS
RAAVNLRGIA ADALSRGDAL LTPGAWHRTA VLDVRRTTGG ALDDAPEQVV AHIGAAAVPA
HVRPFDADHA RLLLDRPLPL AVGDALVLRG SGDHAVLGGV RALDVDPPAL DRRGDGTRRA
AALAALPDAG DATAEVSRRG DLRIDALTRL GIATPDPLPP GIVREGDWLI AADRLESWTA
ALREGVARLH REQPLAPGLT RGAAAGLLGL PDAALLGPVA ARAGLAVEGG HVRDPRQEAG
LGAAEAGIAE LEKRLRAEPF RAPEADDLAA LRLGPRELAT AQRLGRVLRL EGDVILLPTA
PALAMRELAA LSQPFTLSEA RQALGTTRRV AVPLLEHLDA RGWTRRVDGS RREIVR
//
