ID A0A1X7V028_AMPQE Unreviewed; 352 AA.
AC A0A1X7V028;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 28-JAN-2026, entry version 34.
DE RecName: Full=BBSome complex member BBS5 PH domain-containing protein {ECO:0000259|SMART:SM00683};
GN Name=100635647 {ECO:0000313|EnsemblMetazoa:Aqu2.1.33585_001};
OS Amphimedon queenslandica (Sponge).
OC Eukaryota; Metazoa; Porifera; Demospongiae; Heteroscleromorpha;
OC Haplosclerida; Niphatidae; Amphimedon.
OX NCBI_TaxID=400682 {ECO:0000313|EnsemblMetazoa:Aqu2.1.33585_001};
RN [1] {ECO:0000313|Proteomes:UP000007879}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20686567; DOI=10.1038/nature09201;
RA Srivastava M., Simakov O., Chapman J., Fahey B., Gauthier M.E., Mitros T.,
RA Richards G.S., Conaco C., Dacre M., Hellsten U., Larroux C., Putnam N.H.,
RA Stanke M., Adamska M., Darling A., Degnan S.M., Oakley T.H.,
RA Plachetzki D.C., Zhai Y., Adamski M., Calcino A., Cummins S.F.,
RA Goodstein D.M., Harris C., Jackson D.J., Leys S.P., Shu S., Woodcroft B.J.,
RA Vervoort M., Kosik K.S., Manning G., Degnan B.M., Rokhsar D.S.;
RT "The Amphimedon queenslandica genome and the evolution of animal
RT complexity.";
RL Nature 466:720-726(2010).
RN [2] {ECO:0000313|EnsemblMetazoa:Aqu2.1.33585_001}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (MAY-2017) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium membrane
CC {ECO:0000256|ARBA:ARBA00004309}. Cytoplasm, cytoskeleton, microtubule
CC organizing center, centrosome, centriolar satellite
CC {ECO:0000256|ARBA:ARBA00004607}.
CC -!- SIMILARITY: Belongs to the BBS5 family.
CC {ECO:0000256|ARBA:ARBA00005822}.
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DR AlphaFoldDB; A0A1X7V028; -.
DR STRING; 400682.A0A1X7V028; -.
DR EnsemblMetazoa; Aqu2.1.33585_001; Aqu2.1.33585_001; Aqu2.1.33585.
DR EnsemblMetazoa; XM_003386046.3; XP_003386094.1; LOC100635647.
DR KEGG; aqu:100635647; -.
DR eggNOG; ENOG502QR2Z; Eukaryota.
DR InParanoid; A0A1X7V028; -.
DR OMA; PNFGIQY; -.
DR OrthoDB; 10261999at2759; -.
DR Proteomes; UP000007879; Unassembled WGS sequence.
DR GO; GO:0034464; C:BBSome; IEA:InterPro.
DR GO; GO:0034451; C:centriolar satellite; IEA:UniProtKB-SubCell.
DR GO; GO:0036064; C:ciliary basal body; IEA:TreeGrafter.
DR GO; GO:0060170; C:ciliary membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0032266; F:phosphatidylinositol-3-phosphate binding; IEA:TreeGrafter.
DR GO; GO:0060271; P:cilium assembly; IEA:TreeGrafter.
DR InterPro; IPR006606; BBL5.
DR InterPro; IPR030804; BBS5/fem-3.
DR InterPro; IPR014003; BBS5_PH.
DR PANTHER; PTHR21351:SF0; BARDET-BIEDL SYNDROME 5 PROTEIN; 1.
DR PANTHER; PTHR21351; BARDET-BIEDL SYNDROME PROTEIN 5; 1.
DR Pfam; PF07289; BBL5; 1.
DR PIRSF; PIRSF010072; DUF1448; 1.
DR SMART; SM00683; DM16; 2.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000007879}.
FT DOMAIN 32..86
FT /note="BBSome complex member BBS5 PH"
FT /evidence="ECO:0000259|SMART:SM00683"
FT DOMAIN 162..216
FT /note="BBSome complex member BBS5 PH"
FT /evidence="ECO:0000259|SMART:SM00683"
FT REGION 272..301
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 352 AA; 39580 MW; EC208BD093510BF8 CRC64;
MEAFEEEPFC LWQDRDIKFD SNDKALAPRP GETVISKFEA VEDTKGNNGA SGKLTVTNLR
IIWRSTAKPS VNLSIGLMCI FQIKARKATS KLRGQTESVY ILTKCKKTQF EFIFTNLVSD
TPKLFALILA VHRSYETSKL YREIKLRGAI IDNQTLKVLP LEQVYDKING VMNLCSSQGT
LGTMYITNVR VAWHANTNEA FNISVPYLHL ISIKMRESKF GLALVLETHK DTGGYVLGFR
IDPQEKLRST LQQINSLYRV FSAHPIFGVE YETDESVDPS DTTGGDSNEK EGGGAPFEDE
SEIVETSNNV CSAYFADPNK SHDREPFYSE HIGLAMETLP DGYSIKDLWE VT
//
