ID A0A1Y1VI44_9FUNG Unreviewed; 3890 AA.
AC A0A1Y1VI44;
DT 30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT 30-AUG-2017, sequence version 1.
DT 08-OCT-2025, entry version 31.
DE RecName: Full=Non-specific serine/threonine protein kinase {ECO:0008006|Google:ProtNLM};
GN ORFNames=BCR36DRAFT_320871 {ECO:0000313|EMBL:ORX56054.1};
OS Piromyces finnis.
OC Eukaryota; Fungi; Fungi incertae sedis; Chytridiomycota;
OC Chytridiomycota incertae sedis; Neocallimastigomycetes; Neocallimastigales;
OC Neocallimastigaceae; Piromyces.
OX NCBI_TaxID=1754191 {ECO:0000313|EMBL:ORX56054.1, ECO:0000313|Proteomes:UP000193719};
RN [1] {ECO:0000313|EMBL:ORX56054.1, ECO:0000313|Proteomes:UP000193719}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=finn {ECO:0000313|Proteomes:UP000193719};
RG DOE Joint Genome Institute;
RA Haitjema C.H., Gilmore S.P., Henske J.K., Solomon K.V., De Groot R.,
RA Kuo A., Mondo S.J., Salamov A.A., Labutti K., Zhao Z., Chiniquy J.,
RA Barry K., Brewer H.M., Purvine S.O., Wright A.T., Boxma B., Van Alen T.,
RA Hackstein J.H., Baker S.E., Grigoriev I.V., O'Malley M.A.;
RT "Genomes of anaerobic fungi encode conserved fungal cellulosomes for
RT biomass hydrolysis.";
RL Submitted (AUG-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ORX56054.1, ECO:0000313|Proteomes:UP000193719}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=finn {ECO:0000313|Proteomes:UP000193719};
RG DOE Joint Genome Institute;
RA Mondo S.J., Dannebaum R.O., Kuo R.C., Labutti K., Haridas S., Kuo A.,
RA Salamov A., Ahrendt S.R., Lipzen A., Sullivan W., Andreopoulos W.B.,
RA Clum A., Lindquist E., Daum C., Ramamoorthy G.K., Gryganskyi A., Culley D.,
RA Magnuson J.K., James T.Y., O'Malley M.A., Stajich J.E., Spatafora J.W.,
RA Visel A., Grigoriev I.V.;
RT "Pervasive Adenine N6-methylation of Active Genes in Fungi.";
RL Submitted (AUG-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family. TRA1 subfamily.
CC {ECO:0000256|ARBA:ARBA00007234}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ORX56054.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; MCFH01000008; ORX56054.1; -; Genomic_DNA.
DR STRING; 1754191.A0A1Y1VI44; -.
DR OrthoDB; 5570127at2759; -.
DR Proteomes; UP000193719; Unassembled WGS sequence.
DR GO; GO:0035267; C:NuA4 histone acetyltransferase complex; IEA:EnsemblFungi.
DR GO; GO:0005634; C:nucleus; IEA:EnsemblFungi.
DR GO; GO:0000124; C:SAGA complex; IEA:EnsemblFungi.
DR GO; GO:0046695; C:SLIK (SAGA-like) complex; IEA:EnsemblFungi.
DR GO; GO:0004402; F:histone acetyltransferase activity; IEA:EnsemblFungi.
DR GO; GO:0006281; P:DNA repair; IEA:EnsemblFungi.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:EnsemblFungi.
DR CDD; cd05163; PIKK_TRRAP; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR050517; DDR_Repair_Kinase.
DR InterPro; IPR003152; FATC_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR003151; PIK-rel_kinase_FAT.
DR InterPro; IPR014009; PIK_FAT.
DR InterPro; IPR046807; Tra1_central.
DR InterPro; IPR046805; Tra1_ring.
DR PANTHER; PTHR11139; ATAXIA TELANGIECTASIA MUTATED ATM -RELATED; 1.
DR PANTHER; PTHR11139:SF1; TRANSFORMATION_TRANSCRIPTION DOMAIN-ASSOCIATED PROTEIN; 1.
DR Pfam; PF02259; FAT; 1.
DR Pfam; PF02260; FATC; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF20175; Tra1_central; 1.
DR Pfam; PF20206; Tra1_ring; 1.
DR SMART; SM01343; FATC; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; ARM repeat; 2.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51189; FAT; 1.
DR PROSITE; PS51190; FATC; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000193719}.
FT DOMAIN 2664..3231
FT /note="FAT"
FT /evidence="ECO:0000259|PROSITE:PS51189"
FT DOMAIN 3456..3785
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT DOMAIN 3858..3890
FT /note="FATC"
FT /evidence="ECO:0000259|PROSITE:PS51190"
FT REGION 3243..3278
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3795..3859
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3247..3257
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3260..3275
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3798..3809
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3827..3836
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3837..3852
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3890 AA; 451358 MW; 8D29449242501601 CRC64;
MDNQNNQNII KKMDIASTKL NDLNIDIEVK ISILNEIKDS IENIQAVEYS RFLHLFFPVF
FSILTKTEPS FISTHLNQKI RNTVLEIIQR IPHNEALQEY VPDLMKILLD LLKNDNEENG
TICVKIIVDL HKNNKNILEN YVQSFFDIVK EMYGNIKQTV TNVFDDNQQT TNAVENANNK
LSKSMYSFKI LKECPIIIVL LFQLHKKFVQ SNVEAFIPLI IECLELQPEA QKQEHEEAEK
KGEIFIGVSP RIKNRIAYVD FKALQVKTLS FVAYILRGFI QLLEPHKERI AKSVIELMKD
CPPDASGIRK ELLIATRHIW YTSFKFAFMK HIDTLLNENV FVGTGVTSRE TLRSLAYSIL
ADLLHNVRSE LSQKQLSKTI YIYSRNLHDQ SISPNIQTMC VKLLVNLVEE IVKLKNKNEA
RNLLVRLLDA FSKKILSLNT AFSIIIKHHY FQQKQLIRKS ENFANINPPK GYLDLEYSHP
IRSCMGPFET SQDLIKDIKF LLKYLMSGCK LVVVEIKSCS IKNTKIEGEI ENNKEKQNSS
NNTTTEKVPY YNNTAGSENC NDNNQPEFNE DEIEILIRIF REGLKCFNIY NLSNFDEEGQ
IKEGNEIQKQ AAFIQPNLPK DGKEMLDCFS ALFITIEPYA FQEVLTSQIP FFYEQILINP
NLVIISQAFL AKQIISPNFA SILLNFLMEK LEELKEDNEL NCFVLIRLFK FLFMSISLFP
LTNEKILKPH LKSLILKSLE FSSKAHNPLN YFTLLRSLFR SIGGGKFDQL YNEVSPLLCI
LLESLNNLLA NTHKQHMKEL FVELCLTVPV RLSVLIPYLS YLMKPLVIAL KAGPELVSQG
LRTLELCIDN LTQEFLDPIM NPVINDLMDA LWKHLRPHPY NIVHSHTTLR ILGKLGGRNR
KMLRIPSELN YYKHDKAMLD IGLTSNLENL VHMFDLEPCL FVVERLIDKN LASNTLFYKE
QMYQFIKSCI PLLFNIDIGS SELSALLNKY INSKDNFTDI QVIEEEDYEL LVDRVREKTK
VQIEPSYNAV KKVLYCLYSL ASQKGFEDKE VVDLCRNMCI HFAILHIEEI MLAKSKFNIQ
YTKVSSLDVK FSPFSTQIDA FVDAIVDVIA SEEKEKRTVG ENAIKLFYDT CKTLLGNNKD
ILEHLPVFHK LSMRFCLYCF KQEWYYKNGG CFGISLLCSK IDLGTKWMLD HELEFVKSLL
YVLKDTSPEM ASNNIDDATK TLSHVLKVCN RDNDEGQDRQ AEFKNLILLL VSELPNSNGE
VRKTVQLSLQ LLADLTGNEV TDLLAPVQEN LLKPIFAKPL RTLPFSMQIG HIDAVTYCLS
LRPPLLQFND DLTRLIAEAQ ALADAEDQSL IGKGLPHRNV SSLVKLRVTC IKLLSTALNC
EDSALNQTNN LSKKNRIISV FFKSLYSNSN DVVEVANKGL KQVLQQQNKL PKELLQVGLQ
PILTKLGDYK SLTVQGLEGL ERLLELLNNY FKIEIGYKLL EHMKSWEEIA TKENHFNEPL
SEVESIKIIV HILDVFYQLP PVAHVLMDEI ITFVIKIENK LKRKVSSPFR KPLIKYLNKY
VSKSIEYFYK NLTKPNISKL FIDILKSEYA SVLRLEIINN TNNLIENTFA IKKEDNEDAD
ELHYQGILIV NVLCRTHTNW LIQNNNMVIE KVLEVWESPY ITSNFSKEEE LPYNRLQENI
FILEILINYC INKNSDDSDY YIKIIFSMIR AFCYSSIIDY DLLKQFLWED VALKFTDDQK
KLVLNKFLDL FSDPNTTQII KIQTFKYLIN PILYISFTKC ENCNIIDEEL IEKIHLKLWC
PFLLEQSVMK LDDSLKIELL QFTTLLVQYI PSIISNYRKD IIKLEWNLIK VDDLTCKQTA
YVALSRFIEA FDTPGKIVVQ IFAALLRAHQ PEGRILVKQA LDILILVLPK RITSLPGQQN
DPKFPTWVRW TRKIIIEDSQ NNAQLVIIYQ LLIRHSELFY SSRKHFIPQI IASLTKLGLT
PNTAYETRQL TVELIELIIN WEKKYIEENK LNSNNEILKD NNDNTDITTS TNSNNNEINN
INITTTTINN NNNKTDINKK VVTTIDSNLQ EMMITYLIKL LAILNPMNDN RNILAPRIVL
LIKKLINLFP DVIINIGNLE KFIRIEPNEN QANAIKTILD VLKIIVDEKS NLWFIENLSA
ISKYLISYIK CENTIIMESV GNLLISVFKK IYILSKEGRK LVNEIEPLMK EIERIVMQGL
NNMNNIFSII TLIEATYHEQ PEKLDNLIPL LIKLLQKLVK DHINYQPNNN NNNINSNINI
NNGNNMNNSN NNINNNNNIN NNNTNTITTI NNNTNTNTNN IQNGPNDISS QSSNNIVAGN
NNNSMVVRLL TMLLNLLKLR ISNMGDNRRQ VLIAIIQLIE KSKDISLLKN ILDIVSEWIL
IKPESFPTTK EKANIMIKMM VFERRDKSLL EEYLLLVSKI YLNPNFARTE LTIKLEQAFL
LGTRNDNPKI RKLFTQIFDK SIGKGLFTRL NYVIGVQNWE YLSTSFWLHQ ALDILLGSYM
NTKPLYQSSS SYRIVPISHV ESIFRLQLGD NFMDVDDTNP NNIIENHQKF LKNLQTLDVS
NLLMTIRQLI YLDIDMSSQM WINTFVMSWS FLRKKERHDI IKVLIILLAR EYHLKQADFR
PNVIQILLEG ICRSVPTIQL PPQLIKYLGR TFNAWHIAIE LLQNNTPDLK YGIMSSTKDE
EKIKECTMDA LANLYEELNE DDYFYGLWRR RCLFQETNIA ISYEQCKKWN EAQYMYEAAQ
KKARSGSHLY NESEYYLWED HWILCAQKLQ QWDILTDLAK HEGDTNLLLE CAWRVSDWDS
ESEFLQKAIN VYSDVPLARR KIFEAFLLLN QSTENNNKLE EFKKIYDEGV QLTLKKWHML
PEVVSYSHIN LLHMFQQFVE LNEANQIKMN LNNTKVDNIE KKSEELKGIL QTWRERLPNY
WEDINLWSDL VAWRQHIFST INKAYLPIIQ LLNQNTNNSG SNNNAASSYT YRGFHETAWI
INRFAHIARK HGLTDICVNS LSKIYTLPNI EIQEAFYKLK EQAKCYFQSS IDYATGLDVI
NNTNLMYFTD SQTSEFWTLK GQFLSKLNLI SEANEAFSTA TKIEMASPKA WAQWGIYNDN
LFKEHPNEIS YGEYAISCYL QASGLYKNYK SRKYIARILW LLSFDDNKGK LTEIFTKFKG
DYVHWYWIIY IPQLLTCLAN KEAISANIII QKIAKAYPQA LYFLLRTTRE DYKLIKKQAA
MTSNNGRDLH QNPEDSQAKN NNSGSTTIQS QQTQSFGNKK QPWEYVEEIM GTVKTSFPLL
TLSIEKMIDQ IIQKLKPSPD EDIYRLIVAL LTDGVQQLVG RITNFGDTRS LPRGTEANLK
RFHESMSGGH HKYKEAFEED FIKSKPSITE LVEKFRDWRD KLEYQLDLRN TKQHLEYFSH
DLVEFEHKKF DDIEIPGQYL LHKDSNNEFI RIDKFESIVD VVRGHGICYR RLSLRGNDGS
LHPFVVQHPA ARQCRREERI VQLFRIMNSI MERKKDCRKY KIAFHLPLMV PLAPQVRLVQ
DDLSYLSLQE IYEKHCEKSG FHKDDPTILY INSINKIINR DKKNSIKRTK NDVINLKMAI
IQQIEETMVP NTVLTKFVLG KMKQYIDIFI LRKQFTYQMA AVSFMSYVMS IAHRYPHKIN
ISFETGNIWS TELLPSLSPS TFLFGSNEPV PFRFTPNIQT FITPIGVEGV FTNIMMSIAR
ALTEPEFELE NYLGIFIKDE IVSIQNISQK HPTLQDNSLR NYITQNINLI QHRAESLSCK
QERIKIKTFI ENQKDKNVGN QPKSKFDSLN SDAKNKEEND EEDKNNNKNN LSNGLNDKNK
NNDDSNKENN KNDDDDTFKI PANQTLIDLI SQATNPHKLS QLDITWMPYY
//
