ID A0A1Z5IAZ5_9LACO Unreviewed; 269 AA.
AC A0A1Z5IAZ5;
DT 27-SEP-2017, integrated into UniProtKB/TrEMBL.
DT 27-SEP-2017, sequence version 1.
DT 05-FEB-2025, entry version 20.
DE SubName: Full=2-dehydropantoate 2-reductase {ECO:0000313|EMBL:GAW98797.1};
GN Name=apbA_3 {ECO:0000313|EMBL:GAW98797.1};
GN ORFNames=IWT30_00756 {ECO:0000313|EMBL:GAW98797.1};
OS Secundilactobacillus mixtipabuli.
OC Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC Secundilactobacillus.
OX NCBI_TaxID=1435342 {ECO:0000313|EMBL:GAW98797.1, ECO:0000313|Proteomes:UP000198374};
RN [1] {ECO:0000313|EMBL:GAW98797.1, ECO:0000313|Proteomes:UP000198374}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IWT30 {ECO:0000313|EMBL:GAW98797.1,
RC ECO:0000313|Proteomes:UP000198374};
RA Tohno M., Tanizawa Y., Arita M.;
RT "Draft genome sequences of new species of the genus Lactobacillus isolated
RT from orchardgrass silage.";
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the ketopantoate reductase family.
CC {ECO:0000256|ARBA:ARBA00007870}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GAW98797.1}.
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DR EMBL; BCMF01000003; GAW98797.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1Z5IAZ5; -.
DR UniPathway; UPA00028; UER00004.
DR Proteomes; UP000198374; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:TreeGrafter.
DR GO; GO:0008677; F:2-dehydropantoate 2-reductase activity; IEA:UniProtKB-EC.
DR GO; GO:0050661; F:NADP binding; IEA:TreeGrafter.
DR GO; GO:0015940; P:pantothenate biosynthetic process; IEA:UniProtKB-UniPathway.
DR Gene3D; 1.10.1040.10; N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR050838; Ketopantoate_reductase.
DR InterPro; IPR013752; KPA_reductase.
DR InterPro; IPR013332; KPR_N.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43765:SF2; 2-DEHYDROPANTOATE 2-REDUCTASE; 1.
DR PANTHER; PTHR43765; 2-DEHYDROPANTOATE 2-REDUCTASE-RELATED; 1.
DR Pfam; PF02558; ApbA; 1.
DR Pfam; PF08546; ApbA_C; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000198374}.
FT DOMAIN 5..146
FT /note="Ketopantoate reductase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02558"
FT DOMAIN 182..266
FT /note="Ketopantoate reductase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF08546"
SQ SEQUENCE 269 AA; 30530 MW; 25BCF8B62A37FFC8 CRC64;
MKFTMIGAGA MGLRYGILLQ QAGNDVTFID TWQPHIDKIR EQGGVYVSRD HQDRHLVPIK
LETPETYQGD PDILIFFTKQ MQLAGFLKRC EHFFNDRQYA FTCMNGMGHI EKLQQYFADD
KIIAGTALIA TVLNGPGDVD FMGKSGAGKM NMANLTEKPD EMTHRLFDEL QKGNMNPTLT
TNFKGTLMTK VIFNSVINTL CTLFEIQMGE FGNFPKAYDL GRQLIDEAYD VCERAGITLV
STRDEEMHAL DINTRIDMPL HYPSMYTKI
//
