ID A0A226C0P2_9FIRM Unreviewed; 633 AA.
AC A0A226C0P2;
DT 25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT 25-OCT-2017, sequence version 1.
DT 28-JAN-2026, entry version 29.
DE RecName: Full=Selenocysteine-specific elongation factor {ECO:0000256|ARBA:ARBA00015953};
DE AltName: Full=SelB translation factor {ECO:0000256|ARBA:ARBA00031615};
GN Name=selB {ECO:0000313|EMBL:OWZ83940.1};
GN ORFNames=CDO51_06015 {ECO:0000313|EMBL:OWZ83940.1};
OS Natranaerobius trueperi.
OC Bacteria; Bacillati; Bacillota; Clostridia; Natranaerobiales;
OC Natranaerobiaceae; Natranaerobius.
OX NCBI_TaxID=759412 {ECO:0000313|EMBL:OWZ83940.1, ECO:0000313|Proteomes:UP000214588};
RN [1] {ECO:0000313|EMBL:OWZ83940.1, ECO:0000313|Proteomes:UP000214588}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 18760 {ECO:0000313|EMBL:OWZ83940.1,
RC ECO:0000313|Proteomes:UP000214588};
RA Zhao B.;
RT "Draft Genome Sequence of Natranaerobius trueperi halophilic,
RT alkalithermophilic bacteria from soda lakes.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Translation factor necessary for the incorporation of
CC selenocysteine into proteins. It probably replaces EF-Tu for the
CC insertion of selenocysteine directed by the UGA codon. SelB binds GTP
CC and GDP. {ECO:0000256|ARBA:ARBA00025526}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OWZ83940.1}.
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DR EMBL; NIQC01000010; OWZ83940.1; -; Genomic_DNA.
DR RefSeq; WP_089023400.1; NZ_NIQC01000010.1.
DR AlphaFoldDB; A0A226C0P2; -.
DR OrthoDB; 9804504at2; -.
DR Proteomes; UP000214588; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:TreeGrafter.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
DR GO; GO:0001514; P:selenocysteine incorporation; IEA:InterPro.
DR CDD; cd04171; SelB; 1.
DR CDD; cd03696; SelB_II; 1.
DR CDD; cd15491; selB_III; 1.
DR Gene3D; 1.10.10.2770; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR057335; Beta-barrel_SelB.
DR InterPro; IPR050055; EF-Tu_GTPase.
DR InterPro; IPR004161; EFTu-like_2.
DR InterPro; IPR031157; G_TR_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR015191; SelB_WHD4.
DR InterPro; IPR005225; Small_GTP-bd.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR009001; Transl_elong_EF1A/Init_IF2_C.
DR InterPro; IPR004535; Transl_elong_SelB.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR NCBIfam; TIGR00475; selB; 1.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR43721:SF22; ELONGATION FACTOR TU, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43721; ELONGATION FACTOR TU-RELATED; 1.
DR Pfam; PF25461; Beta-barrel_SelB; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF03144; GTP_EFTU_D2; 1.
DR Pfam; PF09107; WHD_3rd_SelB; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR SUPFAM; SSF50465; EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 2.
DR PROSITE; PS00301; G_TR_1; 1.
DR PROSITE; PS51722; G_TR_2; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Elongation factor {ECO:0000313|EMBL:OWZ83940.1};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000214588}.
FT DOMAIN 1..173
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
SQ SEQUENCE 633 AA; 71626 MW; 7F0988A94222564D CRC64;
MHLVVGTAGH VDHGKTKLIE KLTGKDTDRL QEEKDRGISV DLGFAPFTMP SGGVAGVVDV
PGHEKFIHNM LAGIAGIDLV LLVIDVNEGI MPQTKEHLAI MELLEIKSGI VVLTKVDQAE
EEWIDLMEEE VRESLAGTFL DNEPVIRTSV VSEEGIDDLK EAIDDKSQDI SPKDEDGPIR
MPIDRSFKIS GFGTVVTGTL VSGTINKDDE LEVVPSNTKT RARSLQVHGK SVEKAVAGQR
VAINVPNVTS ENLERGYVLS QPNYFQEVSK CDVKISMLED TTWELKNGTP IHLHVGAGET
IARVYFYGQK KLEPGESSYA QLRLEKPLAI FRKDKFIIRS YSPVTTIGGG FVLEHNATKK
PLNSKQTIER LKTLEIGDPK QIVNQIIQKN GVITINELKK ETGIIGENLT KILDELIEEK
EVKLVENYVI SSEKRKVLKD QITNMIIDYH KIYPLRDGKP KAEVISWLKE FGLDEKASIL
VLEEIYNEEN IDNQNDYIFM EDFIPSPNNK QQYYIDSILK LYDENEFKPP QLNEISTQLK
IEDNELKEII DYLIRKGDVI KITEGYYISS HILEKAIELL KTHFENNSTI SIGEWRDILD
TSRKYALPLL EYFDRIRLTK RDGDIRVLLN KKD
//
