ID A0A238BVY1_9BILA Unreviewed; 451 AA.
AC A0A238BVY1;
DT 25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT 25-OCT-2017, sequence version 1.
DT 18-JUN-2025, entry version 26.
DE RecName: Full=peptidyl-tRNA hydrolase {ECO:0000256|ARBA:ARBA00013260};
DE EC=3.1.1.29 {ECO:0000256|ARBA:ARBA00013260};
GN ORFNames=X798_04107 {ECO:0000313|EMBL:OZC08875.1};
OS Onchocerca flexuosa.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Onchocerca.
OX NCBI_TaxID=387005 {ECO:0000313|EMBL:OZC08875.1, ECO:0000313|Proteomes:UP000242913};
RN [1] {ECO:0000313|EMBL:OZC08875.1, ECO:0000313|Proteomes:UP000242913}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Red Deer {ECO:0000313|EMBL:OZC08875.1};
RA Mitreva M.;
RT "Draft genome of the nematode, Onchocerca flexuosa.";
RL Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=an N-acyl-L-alpha-aminoacyl-tRNA + H2O = an N-acyl-L-amino
CC acid + a tRNA + H(+); Xref=Rhea:RHEA:54448, Rhea:RHEA-COMP:10123,
CC Rhea:RHEA-COMP:13883, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:59874, ChEBI:CHEBI:78442, ChEBI:CHEBI:138191;
CC EC=3.1.1.29; Evidence={ECO:0000256|ARBA:ARBA00048707};
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000256|ARBA:ARBA00004434}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004434}.
CC -!- SIMILARITY: Belongs to the COX16 family.
CC {ECO:0000256|ARBA:ARBA00008370}.
CC -!- SIMILARITY: Belongs to the PTH2 family.
CC {ECO:0000256|ARBA:ARBA00038050}.
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DR EMBL; KZ270001; OZC08875.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A238BVY1; -.
DR OrthoDB; 1733656at2759; -.
DR Proteomes; UP000242913; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:TreeGrafter.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004045; F:peptidyl-tRNA hydrolase activity; IEA:UniProtKB-EC.
DR CDD; cd02430; PTH2; 1.
DR FunFam; 3.40.1490.10:FF:000002; Peptidyl-tRNA hydrolase 2, mitochondrial; 1.
DR Gene3D; 3.40.1490.10; Bit1; 1.
DR Gene3D; 1.10.8.10; DNA helicase RuvA subunit, C-terminal domain; 1.
DR InterPro; IPR020164; Cyt_c_Oxase_assmbl_COX16.
DR InterPro; IPR023476; Pep_tRNA_hydro_II_dom_sf.
DR InterPro; IPR002833; PTH2.
DR InterPro; IPR015940; UBA.
DR InterPro; IPR009060; UBA-like_sf.
DR NCBIfam; TIGR00283; arch_pth2; 1.
DR PANTHER; PTHR12649; PEPTIDYL-TRNA HYDROLASE 2; 1.
DR PANTHER; PTHR12649:SF11; PEPTIDYL-TRNA HYDROLASE 2, MITOCHONDRIAL; 1.
DR Pfam; PF14138; COX16; 1.
DR Pfam; PF01981; PTH2; 1.
DR Pfam; PF22562; UBA_7; 1.
DR SUPFAM; SSF102462; Peptidyl-tRNA hydrolase II; 1.
DR SUPFAM; SSF46934; UBA-like; 1.
DR PROSITE; PS50030; UBA; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:OZC08875.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00022792};
KW Reference proteome {ECO:0000313|Proteomes:UP000242913};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 266..308
FT /note="UBA"
FT /evidence="ECO:0000259|PROSITE:PS50030"
FT REGION 105..152
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 170..189
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 140..152
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 171..189
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 451 AA; 48872 MW; 4AC2DA79FCD8FD7E CRC64;
MNRASSWKFV RKGLPFLAVG GATLLLAYKI QQIKFEFGPS SCTLADAEEI SQFLDTKGIR
HQQESIEAVY QELIEKEDDN WENIRGPRDS EDNKEFLQLN IPATDHRIDS SGDFSEAPPP
PPGFPNTSRE AVRGSERTPV ISSPSGSDFL HASTNERGNI QIIADPTIDR QTSFPSSSAP
TSQSQLTQPV LDPASSSISA IETAVPTQPF YVPAVPDFNQ ETLYTTAESS QSVTSNPLDP
DISLAQTLIA GASCSHPADP ENKEHLVDPA LLAEILQLGF EEAIAVLAIS KTKGIGGAEA
AINWILEHSN ESDFESDEEQ NLMGGTVSTN VISRQYKMVF VVNMSLKMGA GKLAAQVGHA
TLNVYRLAQR SEEGQNALDA WRMSGEMKVV VKGHNTEMLL DLFKQSKDSG LFAYIVSDAG
RTQIPAGSRT VLGIFGPTHL VDVVTGELKL L
//
