ID A0A250Y0X4_CASCN Unreviewed; 441 AA.
AC A0A250Y0X4;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 28-JAN-2026, entry version 42.
DE SubName: Full=Suppressor of cytokine signaling 4 {ECO:0000313|EMBL:JAV37236.1, ECO:0000313|RefSeq:XP_020031160.1};
GN Name=SOCS4 {ECO:0000313|EMBL:JAV37236.1};
GN Synonyms=Socs4 {ECO:0000313|Ensembl:ENSCCNP00000003847.1,
GN ECO:0000313|RefSeq:XP_020031160.1};
OS Castor canadensis (American beaver).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Castorimorpha; Castoridae;
OC Castor.
OX NCBI_TaxID=51338 {ECO:0000313|EMBL:JAV37236.1};
RN [1] {ECO:0000313|EMBL:JAV37236.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ROM106880 {ECO:0000313|EMBL:JAV37236.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:JAV37236.1};
RX PubMed=28087693; DOI=10.1534/g3.116.038208;
RA Lok S., Paton T.A., Wang Z., Kaur G., Walker S., Yuen R.K., Sung W.W.,
RA Whitney J., Buchanan J.A., Trost B., Singh N., Apresto B., Chen N.,
RA Coole M., Dawson T.J., Ho K.Y., Hu Z., Pullenayegum S., Samler K.,
RA Shipstone A., Tsoi F., Wang T., Pereira S.L., Rostami P., Ryan C.A.,
RA Tong A.H., Ng K., Sundaravadanam Y., Simpson J.T., Lim B.K., Engstrom M.D.,
RA Dutton C.J., Kerr K.C., Franke M., Rapley W., Wintle R.F., Scherer S.W.;
RT "De Novo Genome and Transcriptome Assembly of the Canadian Beaver (Castor
RT canadensis).";
RL G3 (Bethesda) 7:755-773(2017).
RN [2] {ECO:0000313|Ensembl:ENSCCNP00000003847.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
RN [3] {ECO:0000313|RefSeq:XP_020031160.1}
RP IDENTIFICATION.
RC TISSUE=Leukocyte {ECO:0000313|RefSeq:XP_020031160.1};
RG RefSeq;
RL Submitted (APR-2025) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
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DR EMBL; GFFV01002709; JAV37236.1; -; Transcribed_RNA.
DR RefSeq; XP_020031160.1; XM_020175571.1.
DR AlphaFoldDB; A0A250Y0X4; -.
DR Ensembl; ENSCCNT00000005031.1; ENSCCNP00000003847.1; ENSCCNG00000004067.1.
DR GeneID; 109693954; -.
DR KEGG; ccan:109693954; -.
DR CTD; 122809; -.
DR OrthoDB; 8820570at2759; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP001732720; Chromosome 3.
DR GO; GO:0005942; C:phosphatidylinositol 3-kinase complex; IEA:TreeGrafter.
DR GO; GO:0046935; F:1-phosphatidylinositol-3-kinase regulator activity; IEA:TreeGrafter.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:TreeGrafter.
DR GO; GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR CDD; cd10385; SH2_SOCS4; 1.
DR CDD; cd03738; SOCS_SOCS4; 1.
DR FunFam; 3.30.505.10:FF:000028; Suppressor of cytokine signaling 5; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR022252; SOCS4/SOCS5_dom.
DR InterPro; IPR035864; SOCS4_SH2.
DR InterPro; IPR037342; SOCS4_SOCS.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10155:SF21; SUPPRESSOR OF CYTOKINE SIGNALING 4; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF12610; SOCS; 1.
DR Pfam; PF07525; SOCS_box; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00253; SOCS; 1.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF158235; SOCS box-like; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50225; SOCS; 1.
PE 4: Predicted;
KW Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW Reference proteome {ECO:0000313|Proteomes:UP001732720};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191};
KW Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 287..382
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 377..426
FT /note="SOCS box"
FT /evidence="ECO:0000259|PROSITE:PS50225"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..11
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 12..29
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 441 AA; 50505 MW; E970259365907275 CRC64;
MAENSENNSK NVDVRPKTSR SRSADRKDGY VWSGKKLSWS KKSESCSDAE TVDAIEKTEV
PLRSQERKHS CSSIELDLDH SCGHRFLGRS LKQKLQDAVG QCFPIKNCSS RHSSGLPSKR
KIHISELMLD KCPFPPRSDL AFRWHFIKRH TAPISPKSDE WVSTDLSQSE LRDGQLKQRR
SMEEDVNSFS HTNVQPCVVT TNNASCRGGP MTGSVMNLVS NNSIEDSDMD SDEEIITLCT
SSRKRNKPKW EMDDEVLQLE TPPKYHTQID YVHCLVPDLL QINNNPCYWG VMDKYAAEAL
LEGKPEGTFL LRDSAQEDYL FSVSFRRYSR SLHARIEQWN HNFSFDAHDP CVFHSPDITG
LLEHYKDPSA CMFFEPLLST PLIRTFPFSL QHICRTVICN CTTYDGIDAL PIPPSMKLYL
KEYHYKSKVR VLRIDAPEQQ C
//
