ID A0A250YHN0_CASCN Unreviewed; 407 AA.
AC A0A250YHN0;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 28-JAN-2026, entry version 42.
DE RecName: Full=Proteasomal ubiquitin receptor ADRM1 {ECO:0000256|ARBA:ARBA00068549};
DE AltName: Full=110 kDa cell membrane glycoprotein {ECO:0000256|ARBA:ARBA00083501};
DE AltName: Full=Adhesion-regulating molecule 1 {ECO:0000256|ARBA:ARBA00078376};
DE AltName: Full=Rpn13 homolog {ECO:0000256|ARBA:ARBA00079688};
GN Name=ADRM1 {ECO:0000313|EMBL:JAV43054.1};
GN Synonyms=Adrm1 {ECO:0000313|Ensembl:ENSCCNP00000014521.1,
GN ECO:0000313|RefSeq:XP_020023372.1};
OS Castor canadensis (American beaver).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Castorimorpha; Castoridae;
OC Castor.
OX NCBI_TaxID=51338 {ECO:0000313|EMBL:JAV43054.1};
RN [1] {ECO:0000313|EMBL:JAV43054.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Ward {ECO:0000313|EMBL:JAV43054.1};
RC TISSUE=Leukocyte {ECO:0000313|EMBL:JAV43054.1};
RX PubMed=28087693; DOI=10.1534/g3.116.038208;
RA Lok S., Paton T.A., Wang Z., Kaur G., Walker S., Yuen R.K., Sung W.W.,
RA Whitney J., Buchanan J.A., Trost B., Singh N., Apresto B., Chen N.,
RA Coole M., Dawson T.J., Ho K.Y., Hu Z., Pullenayegum S., Samler K.,
RA Shipstone A., Tsoi F., Wang T., Pereira S.L., Rostami P., Ryan C.A.,
RA Tong A.H., Ng K., Sundaravadanam Y., Simpson J.T., Lim B.K., Engstrom M.D.,
RA Dutton C.J., Kerr K.C., Franke M., Rapley W., Wintle R.F., Scherer S.W.;
RT "De Novo Genome and Transcriptome Assembly of the Canadian Beaver (Castor
RT canadensis).";
RL G3 (Bethesda) 7:755-773(2017).
RN [2] {ECO:0000313|Ensembl:ENSCCNP00000014521.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
RN [3] {ECO:0000313|RefSeq:XP_020023372.1}
RP IDENTIFICATION.
RC TISSUE=Leukocyte {ECO:0000313|RefSeq:XP_020023372.1};
RG RefSeq;
RL Submitted (APR-2025) to UniProtKB.
CC -!- SUBUNIT: Component of the 19S proteasome regulatory particle complex.
CC The 26S proteasome consists of a 20S core particle (CP) and two 19S
CC regulatory subunits (RP). Interacts with the proteasomal scaffolding
CC protein PSMD1. Interacts with deubiquitinase UCHL5; this interaction
CC activates the auto-inhibited UCHL5 by deoligomerizing it. Interacts
CC with UBQLN2 and ubiquitin. {ECO:0000256|ARBA:ARBA00061738}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the ADRM1 family.
CC {ECO:0000256|ARBA:ARBA00009216}.
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DR EMBL; GFFW01001734; JAV43054.1; -; Transcribed_RNA.
DR RefSeq; XP_020023371.2; XM_020167782.2.
DR RefSeq; XP_020023372.1; XM_020167783.1.
DR AlphaFoldDB; A0A250YHN0; -.
DR Ensembl; ENSCCNT00000019030.1; ENSCCNP00000014521.1; ENSCCNG00000015005.1.
DR GeneID; 109689085; -.
DR CTD; 11047; -.
DR OrthoDB; 340431at2759; -.
DR Proteomes; UP001732720; Chromosome 5.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0008541; C:proteasome regulatory particle, lid subcomplex; IEA:TreeGrafter.
DR GO; GO:0061133; F:endopeptidase activator activity; IEA:TreeGrafter.
DR GO; GO:0070628; F:proteasome binding; IEA:TreeGrafter.
DR CDD; cd13314; PH_Rpn13; 1.
DR FunFam; 1.10.2020.20:FF:000001; Proteasomal ubiquitin receptor ADRM1; 1.
DR FunFam; 2.30.29.70:FF:000001; Proteasomal ubiquitin receptor ADRM1; 1.
DR Gene3D; 1.10.2020.20; -; 1.
DR Gene3D; 2.30.29.70; Proteasomal ubiquitin receptor Rpn13/ADRM1; 1.
DR InterPro; IPR044867; DEUBAD_dom.
DR InterPro; IPR006773; Rpn13/ADRM1.
DR InterPro; IPR044868; Rpn13/ADRM1_Pru.
DR InterPro; IPR038633; Rpn13/ADRM1_Pru_sf.
DR InterPro; IPR032368; RPN13_DEUBAD.
DR InterPro; IPR038108; RPN13_DEUBAD_sf.
DR PANTHER; PTHR12225; ADHESION REGULATING MOLECULE 1 110 KDA CELL MEMBRANE GLYCOPROTEIN; 1.
DR PANTHER; PTHR12225:SF0; PROTEASOMAL UBIQUITIN RECEPTOR ADRM1; 1.
DR Pfam; PF04683; Rpn13_ADRM1_Pru; 1.
DR Pfam; PF16550; RPN13_C; 1.
DR PROSITE; PS51916; DEUBAD; 1.
DR PROSITE; PS51917; PRU; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Proteasome {ECO:0000256|ARBA:ARBA00022942};
KW Receptor {ECO:0000313|EMBL:JAV43054.1, ECO:0000313|RefSeq:XP_020023372.1};
KW Reference proteome {ECO:0000313|Proteomes:UP001732720}.
FT DOMAIN 18..131
FT /note="Pru"
FT /evidence="ECO:0000259|PROSITE:PS51917"
FT DOMAIN 277..391
FT /note="DEUBAD"
FT /evidence="ECO:0000259|PROSITE:PS51916"
FT REGION 196..259
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 381..407
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 196..254
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 387..398
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 407 AA; 42102 MW; 3843C7AB92273183 CRC64;
MTTSGALFPS LVPGSRGSSN KYLVEFRAGK MSLKGTTVTP DKRKGLVYIQ QTDDSLIHFC
WKDRTSGTVE DDLIIFPDDC EFKRVPQCPS GRVYVLKFKA GSKRLFFWMQ EPKTDQDEEH
CRKVNEYLNN PPMPGALGTS GSGGHELSAL GGEGGLQSLL GNMSHSQLMQ LIGPAGLGGL
GGLGALTGPG LASLLGSGGP PASSSSSSSR SQSAAVTPSS STSSARATPA PSAPAAASAT
SPSPAPSSGN GTSTAASPTQ PIQLSDLQSI LATMNVPAGP GGGQQVDLAS VLTPEIMAPI
LANADVQERL LPYLPSGESL PQTADEIQNT LTSPQFQQAL GMFSAALASG QLGPLMCQFG
LPAEAVEAAN KGDVEAFAKA MQNNAKSEQK EGDTKDKKDE EEDMSLD
//
