ID A0A267E1R9_9PLAT Unreviewed; 724 AA.
AC A0A267E1R9;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 02-APR-2025, entry version 23.
DE RecName: Full=RING-type domain-containing protein {ECO:0000259|PROSITE:PS50089};
GN ORFNames=BOX15_Mlig026643g1 {ECO:0000313|EMBL:PAA55505.1};
OS Macrostomum lignano.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX NCBI_TaxID=282301 {ECO:0000313|EMBL:PAA55505.1, ECO:0000313|Proteomes:UP000215902};
RN [1] {ECO:0000313|EMBL:PAA55505.1, ECO:0000313|Proteomes:UP000215902}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DV1 {ECO:0000313|EMBL:PAA55505.1};
RC TISSUE=Whole organism {ECO:0000313|EMBL:PAA55505.1};
RA Berezikov E.;
RT "A platform for efficient transgenesis in Macrostomum lignano, a flatworm
RT model organism for stem cell research.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the TRIM/RBCC family.
CC {ECO:0000256|ARBA:ARBA00008518}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PAA55505.1}.
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DR EMBL; NIVC01002742; PAA55505.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A267E1R9; -.
DR STRING; 282301.A0A267E1R9; -.
DR OrthoDB; 252722at2759; -.
DR Proteomes; UP000215902; Unassembled WGS sequence.
DR GO; GO:0005654; C:nucleoplasm; IEA:TreeGrafter.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:TreeGrafter.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR017868; Filamin/ABP280_repeat-like.
DR InterPro; IPR001298; Filamin/ABP280_rpt.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR001258; NHL_repeat.
DR InterPro; IPR047153; TRIM45/56/19-like.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR25462; BONUS, ISOFORM C-RELATED; 1.
DR PANTHER; PTHR25462:SF285; RING-TYPE DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00630; Filamin; 1.
DR Pfam; PF01436; NHL; 1.
DR Pfam; PF14634; zf-RING_5; 1.
DR SMART; SM00557; IG_FLMN; 1.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF57845; B-box zinc-binding domain; 1.
DR SUPFAM; SSF81296; E set domains; 1.
DR SUPFAM; SSF101898; NHL repeat; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50194; FILAMIN_REPEAT; 1.
DR PROSITE; PS51125; NHL; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000215902};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 32..82
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT REPEAT 328..431
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 446..483
FT /note="NHL"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00504"
FT COILED 226..253
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 724 AA; 77368 MW; BED52F705A7C155E CRC64;
MAFSNSHVMT SSRLVETIQI NFEDFSESFL TCGTCLNLFD AGEHQPKLLP CSHTLCRSCL
QRIMQGPGPG RQAESFRCPI CREGIAVPHG GGAAAFPPSF VVNQLLDLMA SQRRDLVPKC
SIHSGRELLF CETCDTVFCP ACLSHQAKAD HTVLSFSVAV KRMTEILLYK ATLAASQLGS
AYEAVCREVE TLDANAEACM QSVDQAFQQL RDLVDRRHST VRETVKRVKE EKRRALKEQL
ELIGQEKARV ESECEGLQYQ MDVMAITKKI SDLNAKLDTF AGLSEPRENA YMEFSRDSSA
SGVANANVVD DECLRSVEAA LQRCGKVRVS TTHPGLCSVQ LLSGADAATA GLRCSALLHT
VDYHGRRRRD GDDPVSARLE TPGGEQLEIG VVDKGDGSYE LNFLPLSAGR HRLDVRVFGR
PVRDCPLALD VAGRQRPAAK AGGAGRGSQP GQLQAPYAVA VGRNGEVYIS DTGNSRIVVL
DSTLRWLGDL GRSACTGQSA TGLAVDAGGR LWVANWRQRR VFEVEPVEDR ISSSLQSAAF
REPGLVAVGP RGHVIVGDAG AGAVFVCDPT LTEADGALLA RIDGLSGLTA LAVGCHDSAA
SAVQREPQML LCCAVGAKLL VYEIGAGQGS EAESAIGIRH SLTGSACGSS AVTGLALDSD
GRLLASRATG DVEVHSRPLG EFLCRVVPEE AEKLRRPGGV ASLGQGWLAV VDAQGHAVKK
FRYV
//
