ID A0A267FTK1_9PLAT Unreviewed; 730 AA.
AC A0A267FTK1;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 02-APR-2025, entry version 28.
DE RecName: Full=RING-type domain-containing protein {ECO:0008006|Google:ProtNLM};
DE Flags: Fragment;
GN ORFNames=BOX15_Mlig000845g2 {ECO:0000313|EMBL:PAA77150.1};
OS Macrostomum lignano.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX NCBI_TaxID=282301 {ECO:0000313|EMBL:PAA77150.1, ECO:0000313|Proteomes:UP000215902};
RN [1] {ECO:0000313|EMBL:PAA77150.1, ECO:0000313|Proteomes:UP000215902}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DV1 {ECO:0000313|EMBL:PAA77150.1};
RC TISSUE=Whole organism {ECO:0000313|EMBL:PAA77150.1};
RA Berezikov E.;
RT "A platform for efficient transgenesis in Macrostomum lignano, a flatworm
RT model organism for stem cell research.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PAA77150.1}.
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DR EMBL; NIVC01000762; PAA77150.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A267FTK1; -.
DR STRING; 282301.A0A267FTK1; -.
DR OrthoDB; 9978677at2759; -.
DR Proteomes; UP000215902; Unassembled WGS sequence.
DR GO; GO:0071797; C:LUBAC complex; IEA:InterPro.
DR GO; GO:0036435; F:K48-linked polyubiquitin modification-dependent protein binding; IEA:TreeGrafter.
DR GO; GO:0070530; F:K63-linked polyubiquitin modification-dependent protein binding; IEA:TreeGrafter.
DR GO; GO:1990450; F:linear polyubiquitin binding; IEA:TreeGrafter.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:TreeGrafter.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR GO; GO:0097039; P:protein linear polyubiquitination; IEA:TreeGrafter.
DR InterPro; IPR002867; IBR_dom.
DR InterPro; IPR026254; RNF31-like.
DR InterPro; IPR041031; RNF31_C.
DR InterPro; IPR044066; TRIAD_supradom.
DR InterPro; IPR013087; Znf_C2H2_type.
DR InterPro; IPR001841; Znf_RING.
DR PANTHER; PTHR16004:SF2; E3 UBIQUITIN-PROTEIN LIGASE LUBEL; 1.
DR PANTHER; PTHR16004; RING FINGER PROTEIN 31-RELATED; 1.
DR Pfam; PF18091; E3_UbLigase_RBR; 1.
DR Pfam; PF01485; IBR; 1.
DR Pfam; PF22191; IBR_1; 2.
DR SMART; SM00647; IBR; 3.
DR SMART; SM00184; RING; 3.
DR SUPFAM; SSF57850; RING/U-box; 3.
DR PROSITE; PS51873; TRIAD; 1.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000215902};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00042}.
FT DOMAIN 42..73
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 193..420
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS51873"
FT REGION 64..124
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 598..626
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 64..73
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:PAA77150.1"
SQ SEQUENCE 730 AA; 80758 MW; 2ADE6554B8AC7754 CRC64;
NPCRLAAPTR MASASENIEW QCQHCTFINS SVCDTSNPKS RIICSVCSKS VSCEELLDLH
QRQQRAQHLE RAPKPKPRKN QQHRQSFDDE SRASWSLRDA ETDAAAEPLS ISMSQRFSRT
RMSETSSTLG LRRCIGEERD PGAVEANDIF TRSSKPFYPT HRATEGVLQW DQIRPLRAIS
IRNSKAAPME TTASKECPVC IDDKKLVEVP LCDCEVCSDC LCQQIEVRLM HDSSVSVLTC
PVCDKLDDRA LTDTSCEYFP LLQRLLAGQL KPAVMKKLDE RLRDWRLKLT DNFCWCSGCS
NGFEVSEHHD RQVRCPHCGK ETCRKCGKAW HERHRGVSCQ QFGEWRQQTD LSERGLAQFL
ESRGSSCPKC GFQFELSRGG CLHLTCRQCK AEFCSDCGSL FVRQECCGGN KGLHCHHGSE
CVETFRDWPL EKVRQTDLSE RGLAQFLESR GSSCPKCGFQ FELSRGGCLH LTCRQCKAEF
CSDCGSLFVR QECCGGNKGL HCHHGSECVE TFRDWPLEKV RQAALERGVQ LELVGVAGAV
GRCSVQEQKE TSGGGLEDGE CGRPVVEAGL CESHLKEALA SAMRGNKKKD RVGAPDFLAG
PMSSKVGKAQ RPTSAPLVAP SKSLNPGLAQ RPMRLDFFSS NNKPKLNFNR RDLSPTLSEI
STSVDFACPH CTAVSPTAPS VSNGSRVLCT VCGKTTPSKG GSGADGAFSG SDSMFNSYDV
DFESCLDIWD
//
