ID A0A286XY48_CAVPO Unreviewed; 217 AA.
AC A0A286XY48;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 10-JUN-2026, entry version 35.
DE RecName: Full=C-X-C motif chemokine 16 {ECO:0000256|ARBA:ARBA00017995};
DE AltName: Full=Transmembrane chemokine CXCL16 {ECO:0000256|ARBA:ARBA00032815};
GN Name=Cxcl16 {ECO:0000313|Ensembl:ENSCPOP00000030214.1};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000030214.1, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000030214.1}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000030214.1};
RG Ensembl;
RL Submitted (JAN-2026) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the intercrine alpha (chemokine CxC) family.
CC {ECO:0000256|ARBA:ARBA00010665}.
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DR EMBL; AAKN02044433; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A286XY48; -.
DR FunCoup; A0A286XY48; 385.
DR STRING; 10141.ENSCPOP00000030214; -.
DR Ensembl; ENSCPOT00000043390.1; ENSCPOP00000030214.1; ENSCPOG00000032022.1.
DR KEGG; cpoc:101787378; -.
DR VEuPathDB; HostDB:ENSCPOG00000032022; -.
DR GeneTree; ENSGT00390000002148; -.
DR InParanoid; A0A286XY48; -.
DR OMA; CGHAYRK; -.
DR OrthoDB; 9836360at2759; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000032022; Expressed in zone of skin and 13 other cell types or tissues.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008009; F:chemokine activity; IEA:InterPro.
DR GO; GO:0005041; F:low-density lipoprotein particle receptor activity; IEA:InterPro.
DR GO; GO:0005044; F:scavenger receptor activity; IEA:InterPro.
DR GO; GO:0030307; P:positive regulation of cell growth; IEA:InterPro.
DR GO; GO:0030335; P:positive regulation of cell migration; IEA:InterPro.
DR GO; GO:0006898; P:receptor-mediated endocytosis; IEA:InterPro.
DR GO; GO:0034612; P:response to tumor necrosis factor; IEA:InterPro.
DR GO; GO:0034341; P:response to type II interferon; IEA:InterPro.
DR GO; GO:0010818; P:T cell chemotaxis; IEA:TreeGrafter.
DR InterPro; IPR026296; CXCL16.
DR InterPro; IPR048585; CXCL16_dom.
DR PANTHER; PTHR14385:SF0; C-X-C MOTIF CHEMOKINE 16; 1.
DR PANTHER; PTHR14385; CXC CHEMOKINE LIGAND; 1.
DR Pfam; PF20902; CXCL16; 1.
PE 3: Inferred from homology;
KW Chemotaxis {ECO:0000256|ARBA:ARBA00022500};
KW Cytokine {ECO:0000256|ARBA:ARBA00022514};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 177..199
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 7..96
FT /note="C-X-C motif chemokine 16"
FT /evidence="ECO:0000259|Pfam:PF20902"
FT REGION 95..124
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 217 AA; 23318 MW; A6C6A9AFE9CAD2DA CRC64;
PRLSASGDGN EGSIAGSCHC DKTVSSDLVT AQLVTHVRKY VKGYQLCAPL TYRFQLYSQS
VCGGSRDQWV LEVVSCLDRG ECGHAYRKNP VHQKIFASPG TPIPRPTEGH SPESSTPAQK
YPPSALQSIT KPTLLPGTHS LDTRLTHLSE TSTPMVGYGL EAGHRAMENQ QGAIGSASAV
VSVVLGATVV IAIGVFFCIR RQRRTRQLQQ YTPGVIA
//
