ID A0A287BIN8_PIG Unreviewed; 1201 AA.
AC A0A287BIN8;
DT 11-DEC-2019, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 1.
DT 28-JAN-2026, entry version 29.
DE SubName: Full=Collagen type XV alpha 1 chain {ECO:0000313|Ensembl:ENSSSCP00000056238.2};
GN Name=COL15A1 {ECO:0000313|Ensembl:ENSSSCP00000056238.2,
GN ECO:0000313|VGNC:VGNC:86866};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000056238.2, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSSCP00000056238.2}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000056238.2};
RX PubMed=32543654;
RA Warr A., Affara N., Aken B., Beiki H., Bickhart D.M., Billis K., Chow W.,
RA Eory L., Finlayson H.A., Flicek P., Giron C.G., Griffin D.K., Hall R.,
RA Hannum G., Hourlier T., Howe K., Hume D.A., Izuogu O., Kim K., Koren S.,
RA Liu H., Manchanda N., Martin F.J., Nonneman D.J., O'Connor R.E.,
RA Phillippy A.M., Rohrer G.A., Rosen B.D., Rund L.A., Sargent C.A.,
RA Schook L.B., Schroeder S.G., Schwartz A.S., Skinner B.M., Talbot R.,
RA Tseng E., Tuggle C.K., Watson M., Smith T.P.L., Archibald A.L.;
RT "An improved pig reference genome sequence to enable pig genetics and
RT genomics research.";
RL Gigascience 9:giaa051-giaa051(2020).
RN [3] {ECO:0000313|Ensembl:ENSSSCP00000056238.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (AUG-2025) to UniProtKB.
RN [4] {ECO:0000313|Ensembl:ENSSSCP00000056238.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2025) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A287BIN8; -.
DR PaxDb; 9823-ENSSSCP00000025497; -.
DR Ensembl; ENSSSCT00000053184.2; ENSSSCP00000056238.2; ENSSSCG00000005380.5.
DR VGNC; VGNC:86866; COL15A1.
DR GeneTree; ENSGT00940000158302; -.
DR Proteomes; UP000008227; Chromosome 1.
DR Bgee; ENSSSCG00000005380; Expressed in subcutaneous adipose tissue and 38 other cell types or tissues.
DR ExpressionAtlas; A0A287BIN8; baseline and differential.
DR GO; GO:0005581; C:collagen trimer; IEA:UniProtKB-KW.
DR CDD; cd00247; Endostatin-like; 1.
DR CDD; cd00110; LamG; 1.
DR FunFam; 3.40.1620.70:FF:000002; Collagen alpha 1 (XV) chain; 1.
DR FunFam; 2.60.120.200:FF:000039; Collagen XV alpha 1 chain; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 3.40.1620.70; -; 1.
DR Gene3D; 3.10.100.10; Mannose-Binding Protein A, subunit A; 1.
DR InterPro; IPR016186; C-type_lectin-like/link_sf.
DR InterPro; IPR008160; Collagen.
DR InterPro; IPR050149; Collagen_superfamily.
DR InterPro; IPR010515; Collagenase_NC10/endostatin.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR016187; CTDL_fold.
DR InterPro; IPR001791; Laminin_G.
DR InterPro; IPR048287; TSPN-like_N.
DR InterPro; IPR045463; XV/XVIII_trimerization_dom.
DR PANTHER; PTHR24023; COLLAGEN ALPHA; 1.
DR PANTHER; PTHR24023:SF1082; COLLAGEN TRIPLE HELIX REPEAT; 1.
DR Pfam; PF01391; Collagen; 2.
DR Pfam; PF20010; Collagen_trimer; 1.
DR Pfam; PF06482; Endostatin; 1.
DR Pfam; PF13385; Laminin_G_3; 1.
DR SMART; SM00282; LamG; 1.
DR SMART; SM00210; TSPN; 1.
DR SUPFAM; SSF56436; C-type lectin-like; 2.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
PE 1: Evidence at protein level;
KW Collagen {ECO:0000256|ARBA:ARBA00023119};
KW Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Hydroxylation {ECO:0000256|ARBA:ARBA00023278};
KW Proteomics identification {ECO:0007829|PeptideAtlas:A0A287BIN8};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 18..206
FT /note="Thrombospondin-like N-terminal"
FT /evidence="ECO:0000259|SMART:SM00210"
FT DOMAIN 67..205
FT /note="Laminin G"
FT /evidence="ECO:0000259|SMART:SM00282"
FT REGION 201..229
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 245..297
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 354..392
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 476..734
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 767..832
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 880..914
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 509..518
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 544..554
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 580..590
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 655..669
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 704..718
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 792..805
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1201 AA; 123549 MW; 0321C0BD149E9A55 CRC64;
MCDAWPLSLP AELASQGHLD LTELIGVPLP SSVSFVTGYG GFPAYSFGPG ANVGRPARTL
IPPTFFRDFA ISVTVKPSSA RGGVLFAITD AFQKVIYLGL RLSAVEDGRQ RVILYYTEPG
SQVSHEAASF PVPVMTHRWN RFAVVVQGEE ASLLVECEEQ GHVSFPRSSQ ALAFEPSAGI
FVGNAGATGL ERFTGSIQQL TVHSDPRTPE ELCEAEESSA SGEASGLQET DGVAEMVEAV
TYTQAPSEPA EVEPINMPPT PSPLSEDAEL SGEPVPEGTQ GTTNLSAFPH SSPEQGSGEI
LNDTLERVHT VDGAPVTDTG SGDGAFLHVI EESPHTEEGL AATAAAVESE VTISTAGEAE
TESVPTEGPT LSMSTKDPGE EVTLGPDDEE GSAVTAAEEA EVLVSSPGEA EAGSVPTGEL
TLSMSTQDPG EGGPVHEESL TTAVTAKAPL STFEEEASRV PTDGLAPLIP TVAPEQVFTS
GPGDDDLAAA ATEEPLISSG AEELSGVPPE GPPLPLPTVA PERGGAPGEE GEGLPGPPPP
TRPAGPTAGA EAEGSSLGWG LDIGSGSGDP VRSEELLRGP PGPPGPPGLP GIPGRPGTDV
FVGPPGSPGE DGPAGEPGPP GRIISLSSSL QGDPGSRGLP GPPGKNGQVG TPGVMGPPGP
PGPPGPPGPG CAMGQGFEDT EGSGSIRLLH EPRISGPVAS VGPKGEKGDQ GPKGERGMDG
ASIVGPPGPR GPPGRIEVLS SVSITRSECG CVFPAFAKGD RSLTTTSGPS GLLGMQGGEK
GEPGAILTGD VPLERLRGKK GEPGEHGAPG PMGPKGPPGH KGEFGLPGRP GRPGLNGLKG
AKGDRGVMMP VSATLGPPWG WGGGDTSAVF PIPVRPHCKT PVSSVKGEKG SWGLPGSKGE
KGDQGAQGPP GPPVDPAYLR HFLNSLKGEN GDRGMKGEKG DTYEGFSVSG PPGLPGSPGL
VVSRDPSTSS SLKSCSFPRS PQSFSNMDDM LQKAHLVIEG TFIYLRDSTE FFIRVRDGWK
KLQLGELIPL PADSLPPPAL SGNPHQPQLP LTSISSVNYD RPALHLVALN TPSSGDLRAD
FQCFQQARAA GLLSTYRAFL SSHLQDLSTI VRKAERYSLP IVNLKGQVLF NNWDSIFSGH
GGQFNTHVPI YSFDGRDVMT DPSWPQKVVW HGSSTHGVRL VDQYCEAWRT ADVAVMGLAP
R
//
