ID A0A287BQN5_PIG Unreviewed; 1485 AA.
AC A0A287BQN5;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2022, sequence version 3.
DT 28-JAN-2026, entry version 45.
DE SubName: Full=Collagen type XVIII alpha 1 chain {ECO:0000313|Ensembl:ENSSSCP00000058425.3};
GN Name=COL18A1 {ECO:0000313|Ensembl:ENSSSCP00000058425.3,
GN ECO:0000313|VGNC:VGNC:86869};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000058425.3, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSSCP00000058425.3}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000058425.3};
RX PubMed=32543654;
RA Warr A., Affara N., Aken B., Beiki H., Bickhart D.M., Billis K., Chow W.,
RA Eory L., Finlayson H.A., Flicek P., Giron C.G., Griffin D.K., Hall R.,
RA Hannum G., Hourlier T., Howe K., Hume D.A., Izuogu O., Kim K., Koren S.,
RA Liu H., Manchanda N., Martin F.J., Nonneman D.J., O'Connor R.E.,
RA Phillippy A.M., Rohrer G.A., Rosen B.D., Rund L.A., Sargent C.A.,
RA Schook L.B., Schroeder S.G., Schwartz A.S., Skinner B.M., Talbot R.,
RA Tseng E., Tuggle C.K., Watson M., Smith T.P.L., Archibald A.L.;
RT "An improved pig reference genome sequence to enable pig genetics and
RT genomics research.";
RL Gigascience 9:giaa051-giaa051(2020).
RN [3] {ECO:0000313|Ensembl:ENSSSCP00000058425.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (AUG-2025) to UniProtKB.
RN [4] {ECO:0000313|Ensembl:ENSSSCP00000058425.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2025) to UniProtKB.
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DR Ensembl; ENSSSCT00000057398.3; ENSSSCP00000058425.3; ENSSSCG00000038089.3.
DR VGNC; VGNC:86869; COL18A1.
DR GeneTree; ENSGT00940000158212; -.
DR Proteomes; UP000008227; Chromosome 13.
DR Bgee; ENSSSCG00000038089; Expressed in liver and 39 other cell types or tissues.
DR ExpressionAtlas; A0A287BQN5; baseline and differential.
DR GO; GO:0005581; C:collagen trimer; IEA:UniProtKB-KW.
DR FunFam; 3.40.1620.70:FF:000003; Collagen type XVIII alpha 1; 1.
DR FunFam; 2.60.120.200:FF:000039; Collagen XV alpha 1 chain; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 3.40.1620.70; -; 1.
DR Gene3D; 3.10.100.10; Mannose-Binding Protein A, subunit A; 1.
DR InterPro; IPR016186; C-type_lectin-like/link_sf.
DR InterPro; IPR008160; Collagen.
DR InterPro; IPR050149; Collagen_superfamily.
DR InterPro; IPR010515; Collagenase_NC10/endostatin.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR016187; CTDL_fold.
DR InterPro; IPR010363; DUF959_COL18_N.
DR InterPro; IPR048287; TSPN-like_N.
DR InterPro; IPR045463; XV/XVIII_trimerization_dom.
DR PANTHER; PTHR24023; COLLAGEN ALPHA; 1.
DR PANTHER; PTHR24023:SF1060; COLLAGEN ALPHA-1(IV) CHAIN; 1.
DR Pfam; PF01391; Collagen; 1.
DR Pfam; PF20010; Collagen_trimer; 1.
DR Pfam; PF06121; DUF959; 1.
DR Pfam; PF06482; Endostatin; 1.
DR Pfam; PF13385; Laminin_G_3; 1.
DR SMART; SM00210; TSPN; 1.
DR SUPFAM; SSF56436; C-type lectin-like; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
PE 1: Evidence at protein level;
KW Collagen {ECO:0000256|ARBA:ARBA00023119};
KW Proteomics identification {ECO:0007829|PeptideAtlas:A0A287BQN5};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 269..457
FT /note="Thrombospondin-like N-terminal"
FT /evidence="ECO:0000259|SMART:SM00210"
FT REGION 1..39
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 79..265
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 458..683
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 752..955
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 990..1013
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1026..1106
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1179..1208
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1312..1346
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1391..1485
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 128..140
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 153..167
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 198..208
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 209..232
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 239..249
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 468..478
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 521..533
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 536..561
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 565..574
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 601..616
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 663..677
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 786..796
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 824..839
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 841..856
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1070..1086
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1322..1333
FT /note="Gly residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1402..1424
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1485 AA; 152456 MW; 5F0F2353D7B65F97 CRC64;
MNGELAAGPG AGGGSGRAPP PDGRGRPLLP GAHSAMAPDP SGRPGHLGLL LLLACCLAAT
WADPFPWLWF SEATMPKATP ASVPQATPAP VPPGSSPEQR PETPPRTWTP GMAPPTRGKP
RPALSLVWRG WRGARARAPL SPRPPREPGP QGGEHRGCGS QDPERGSGHP ALHPAVGRHH
APRELRRRGD ASPPTPTDPL TTPGPSSTLW ESGTTLWLSS GAPSSPDTQR TEAGTQPLPT
QPPPSPGGPL APFRAPSVPP PAPEGEAVEV GLQQMLGEPL PRQVALVHDP DVGPAYEFDG
ISGVGQAALS LVPRTFFHDF SLLMRVRPAS AGAGVLFAVT DAAQAVVLVG VKLAAARGGQ
QQVQLLYTEP GATRTRTAAS FTLPALHGRW THLALSVDGA HVALFVDCEE VQLEPLSRSL
RALQLEPDAR LFVAQAGRAD PDKFQGMISE LRVRGDPQVS PLQCRYGDED EDDSDNEASG
DLGSGLAEEA GERLGAPSGA PLRPRLPEAP PVTSPPLAGA GDEEDSRTEE VEEATTVPSP
GAQTLPGSGA VTTWDGSSWS PGDSLEERGL KGQEEPGAQG LPGQASPQGP TGPVMRSPEA
QPVPGPQGPP GPPGPPGKDG APGRDGEPVS AQVPGDTGPQ GFPGTPGDVG PKGEKGDPGV
GPRGPPGPQG PPGPPGPSFR HDKLTFIDME GSGFGGDLES LRVSVPWPSS PTVEPVGCAE
AWREGAGATF GCTACRDPSV FFCVQGPRGF PGPPGPPGVP GLPGEPGRFG MNSSDVPGPA
GACGHTGCPG PTHTSSPGPP GFPGRDGQAG QTGQKGSVGS KGDPGPVGAP GNPGLAGVPG
PAGPPGPPGP PGPPGPGLAA GFDDMEGSGG PFWWAAQGAD RPQGPAGPKG DLGSKGQPGL
PGPKGEKGEP GTVFSPDGRP LTPAQKGAKV RGAWGPYGRP GHKGEIGFPG RPGRPGMNGL
KGEKGEPGDA SVGFSLRVSV LQAVGVGGKG TPRPGRLAPL ARVPELTGGS PSELKHGSFR
GWWQMQPRPS SLLVPGLGTQ GPKGESIRGQ PGPPGPQGPP GIGYEGRQGP PGPPGPPGPP
GPPSFPGPYR QSKPGRERVL GSRDPTGLGF QQVRVWATYQ TMLDKVPEVP EGWLMFVAER
EELYVRVRNG FRKVLVTAAS HPQDNEVAAL QPPVVQLHEG NPYPRREPPQ PTARAWRGDD
IRASPPRLPV AQPYPGAPHH GAYVHPRPVH PTGSPAHTHH DFQPVLHLVA LNSPQSGGLR
GIRGADFQCF QQARAVGLAG TFRAFLSSRL QDLYSIVRRA DRAAVPIVNL RVGGRPSRPR
GPEGGGGRAG GGSSPRHPME LPRGFTFPVH SIPRAVTAQG SPGQGGRARS LSRAVFRGFF
HEQKYVLSGC SEHPVPQDQR GARSSPGGPG LAAGAQQAGA ASAGRRGGRR RPGVGPSQTA
PASLRPPSRL SLGQEVTSQD DLTSPRRTRC CSPAGRPCSR ALRAS
//
