ID A0A2A2AG74_9BURK Unreviewed; 652 AA.
AC A0A2A2AG74;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 28-JAN-2026, entry version 25.
DE RecName: Full=Selenocysteine-specific elongation factor {ECO:0000256|ARBA:ARBA00015953};
DE AltName: Full=SelB translation factor {ECO:0000256|ARBA:ARBA00031615};
GN Name=selB {ECO:0000313|EMBL:PAT37555.1};
GN ORFNames=CK625_04500 {ECO:0000313|EMBL:PAT37555.1};
OS Vandammella animalimorsus.
OC Bacteria; Pseudomonadati; Pseudomonadota; Betaproteobacteria;
OC Burkholderiales; Comamonadaceae; Vandammella.
OX NCBI_TaxID=2029117 {ECO:0000313|EMBL:PAT37555.1, ECO:0000313|Proteomes:UP000218054};
RN [1] {ECO:0000313|EMBL:PAT37555.1, ECO:0000313|Proteomes:UP000218054}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NML00-0135 {ECO:0000313|EMBL:PAT37555.1,
RC ECO:0000313|Proteomes:UP000218054};
RA Bernier A.-M., Bernard K.;
RT "WGS of Clinical strains of the CDC Group NO-1 linked to zoonotic
RT infections in humans.";
RL Submitted (AUG-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Translation factor necessary for the incorporation of
CC selenocysteine into proteins. It probably replaces EF-Tu for the
CC insertion of selenocysteine directed by the UGA codon. SelB binds GTP
CC and GDP. {ECO:0000256|ARBA:ARBA00025526}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PAT37555.1}.
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DR EMBL; NSJB01000002; PAT37555.1; -; Genomic_DNA.
DR RefSeq; WP_095539123.1; NZ_NSJB01000002.1.
DR AlphaFoldDB; A0A2A2AG74; -.
DR Proteomes; UP000218054; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
DR GO; GO:0001514; P:selenocysteine incorporation; IEA:InterPro.
DR CDD; cd04171; SelB; 1.
DR CDD; cd03696; SelB_II; 1.
DR CDD; cd15491; selB_III; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 3.
DR InterPro; IPR057335; Beta-barrel_SelB.
DR InterPro; IPR050055; EF-Tu_GTPase.
DR InterPro; IPR004161; EFTu-like_2.
DR InterPro; IPR015190; Elong_fac_SelB-wing-hlx_typ-2.
DR InterPro; IPR031157; G_TR_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR015191; SelB_WHD4.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR009001; Transl_elong_EF1A/Init_IF2_C.
DR InterPro; IPR004535; Transl_elong_SelB.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR InterPro; IPR048931; WHD_2nd_SelB_bact.
DR NCBIfam; TIGR00475; selB; 1.
DR PANTHER; PTHR43721; ELONGATION FACTOR TU-RELATED; 1.
DR PANTHER; PTHR43721:SF9; GTP-BINDING PROTEIN 1; 1.
DR Pfam; PF25461; Beta-barrel_SelB; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF03144; GTP_EFTU_D2; 1.
DR Pfam; PF09106; WHD_2nd_SelB; 1.
DR Pfam; PF21214; WHD_2nd_SelB_bact; 1.
DR Pfam; PF09107; WHD_3rd_SelB; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR SUPFAM; SSF50465; EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 3.
DR PROSITE; PS00301; G_TR_1; 1.
DR PROSITE; PS51722; G_TR_2; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Elongation factor {ECO:0000313|EMBL:PAT37555.1};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000218054}.
FT DOMAIN 1..176
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
SQ SEQUENCE 652 AA; 69977 MW; 4CFB5E59A331B603 CRC64;
MIIGTAGHID HGKTALVRAL TGVDTDRLPE EKARGISIEL SYAYLPVPGT QQVLGFIDVP
GHEKFVHTMA AGAVGIDHAL LVIAADDGPM PQTREHLAIL ELLGVRQGCV ALNKADRATP
ARLAAVQAEV AALLQGTPLA GAPVFATNAL DAADAGLAAL RAHLLDAAQR FPARPSQGLF
RLAVDRSFTL PGQGTIVTGT VFGGSVRVGD VLRHSPSGQS VRVRSIHAQN QPAQAGHSGQ
RVALNLAGIE RTAIARGDWM AEPQALQATR RLDVQLRVLA SQPQPINPSG QTEASAAKPI
GPWTSVHLHL GTAHRTAHVV PLEGSHIACG QQARAQLVLD EEVFVTAGDR FILRNAQASQ
TIAGGQVLDP NAPERKRRSP ERMAYLDAVQ TAIDTGDIAP LIGQAPWGMG RAQLARLLGQ
PARSLPAPPG CIALGADEAE QLLLAPQHWA ALQAKVCEAL ARFHERTPDE PGVNAARLRR
MALPNLPPAA LQSPDTLWRG LLAALLEQGL LAQTGPWLHL PSHRVQLSAQ EEQRAAQLLP
AIAAGRFDPP WVRDLAQAHQ LPEEEVRQLL RKLARQGRLH QVVKDLFYSP EAIDALLAIA
AELARQSPQQ AVQARHFRDA TALGRKRAIQ VLEYFDRSGH TRRIRDAHVM RT
//
