ID A0A2A2TIZ1_9CYAN Unreviewed; 365 AA.
AC A0A2A2TIZ1;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 08-OCT-2025, entry version 24.
DE RecName: Full=Peptide chain release factor 1 {ECO:0000256|ARBA:ARBA00050039, ECO:0000256|HAMAP-Rule:MF_00093};
DE Short=RF-1 {ECO:0000256|HAMAP-Rule:MF_00093};
GN Name=prfA {ECO:0000256|HAMAP-Rule:MF_00093,
GN ECO:0000313|EMBL:PAX54172.1};
GN ORFNames=CK510_12580 {ECO:0000313|EMBL:PAX54172.1};
OS Brunnivagina elsteri CCALA 953.
OC Bacteria; Bacillati; Cyanobacteriota; Cyanophyceae; Nostocales;
OC Calotrichaceae; Brunnivagina.
OX NCBI_TaxID=987040 {ECO:0000313|EMBL:PAX54172.1, ECO:0000313|Proteomes:UP000218238};
RN [1] {ECO:0000313|EMBL:PAX54172.1, ECO:0000313|Proteomes:UP000218238}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CCALA 953 {ECO:0000313|EMBL:PAX54172.1,
RC ECO:0000313|Proteomes:UP000218238};
RA Gagunashvili A.N., Elster J., Andresson O.S.;
RT "Draft genome sequence of filamentous cyanobacterium Calothrix elsteri
RT CCALA 953.";
RL Submitted (AUG-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Peptide chain release factor 1 directs the termination of
CC translation in response to the peptide chain termination codons UAG and
CC UAA. {ECO:0000256|ARBA:ARBA00002986, ECO:0000256|HAMAP-Rule:MF_00093}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00093}.
CC -!- PTM: Methylated by PrmC. Methylation increases the termination
CC efficiency of RF1. {ECO:0000256|HAMAP-Rule:MF_00093}.
CC -!- SIMILARITY: Belongs to the prokaryotic/mitochondrial release factor
CC family. {ECO:0000256|ARBA:ARBA00010835, ECO:0000256|HAMAP-
CC Rule:MF_00093}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PAX54172.1}.
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DR EMBL; NTFS01000119; PAX54172.1; -; Genomic_DNA.
DR RefSeq; WP_095722032.1; NZ_NTFS01000119.1.
DR AlphaFoldDB; A0A2A2TIZ1; -.
DR OrthoDB; 9806673at2; -.
DR Proteomes; UP000218238; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016149; F:translation release factor activity, codon specific; IEA:UniProtKB-UniRule.
DR FunFam; 3.30.160.20:FF:000004; Peptide chain release factor 1; 1.
DR FunFam; 3.30.70.1660:FF:000002; Peptide chain release factor 1; 1.
DR FunFam; 3.30.70.1660:FF:000014; Peptide chain release factor 1; 1.
DR Gene3D; 3.30.160.20; -; 1.
DR Gene3D; 3.30.70.1660; -; 1.
DR Gene3D; 6.10.140.1950; -; 1.
DR HAMAP; MF_00093; Rel_fac_1; 1.
DR InterPro; IPR005139; PCRF.
DR InterPro; IPR000352; Pep_chain_release_fac_I.
DR InterPro; IPR045853; Pep_chain_release_fac_I_sf.
DR InterPro; IPR050057; Prokaryotic/Mito_RF.
DR InterPro; IPR004373; RF-1.
DR NCBIfam; TIGR00019; prfA; 1.
DR NCBIfam; NF001859; PRK00591.1; 1.
DR PANTHER; PTHR43804; LD18447P; 1.
DR PANTHER; PTHR43804:SF8; PEPTIDE CHAIN RELEASE FACTOR APG3, CHLOROPLASTIC; 1.
DR Pfam; PF03462; PCRF; 1.
DR Pfam; PF00472; RF-1; 1.
DR SMART; SM00937; PCRF; 1.
DR SUPFAM; SSF75620; Release factor; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00093};
KW Methylation {ECO:0000256|ARBA:ARBA00022481, ECO:0000256|HAMAP-
KW Rule:MF_00093};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917, ECO:0000256|HAMAP-
KW Rule:MF_00093}; Reference proteome {ECO:0000313|Proteomes:UP000218238}.
FT DOMAIN 68..183
FT /note="Peptide chain release factor"
FT /evidence="ECO:0000259|SMART:SM00937"
FT COILED 261..300
FT /evidence="ECO:0000256|SAM:Coils"
FT MOD_RES 239
FT /note="N5-methylglutamine"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00093"
SQ SEQUENCE 365 AA; 41232 MW; A7FF6E46D3D8153F CRC64;
MAEQYLLEKL KSVEQTFHEL TRRLGDPDTA KDQHEYQTIA KARSGLEDVV NSYDNWKIAQ
DDLIGARQIY KESASDPEMQ EIAGFEVKEL EEKIDFLEKR LKVLLLPRDP NDEKNIMLEI
RAGTGGDEAS IWAGDLMRMY TRYAQTQGWK VLLASESLGE MGGWKEVILE IKGNDVYSQL
KFEAGVHRVQ RVPVTEAGGR VHTSTATVAI MPEVDEVEVH IDPKDIEMKT ARSGGAGGQN
VNKVETAADL LHKPTGIRIF CTEERSQLQN KERAMQILRA KLYEIKLQEQ QAEITSARRL
QVGTGSRSEK IRTYNYKDNR VTDHRLNQNF SLTPALEGDI ENIIQSCISQ DQQDQLAELA
ASANN
//
