ID   A0A2B7Y2D7_9EURO        Unreviewed;       644 AA.
AC   A0A2B7Y2D7;
DT   20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT   20-DEC-2017, sequence version 1.
DT   28-JAN-2026, entry version 29.
DE   RecName: Full=Tyrosinase copper-binding domain-containing protein {ECO:0000259|PROSITE:PS00497, ECO:0000259|PROSITE:PS00498};
GN   ORFNames=AJ79_02239 {ECO:0000313|EMBL:PGH15646.1};
OS   Helicocarpus griseus UAMH5409.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Ajellomycetaceae; Helicocarpus.
OX   NCBI_TaxID=1447875 {ECO:0000313|EMBL:PGH15646.1, ECO:0000313|Proteomes:UP000223968};
RN   [1] {ECO:0000313|EMBL:PGH15646.1, ECO:0000313|Proteomes:UP000223968}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UAMH5409 {ECO:0000313|EMBL:PGH15646.1,
RC   ECO:0000313|Proteomes:UP000223968};
RA   Munoz J.F., Mcewen J.G., Clay O.K., Cuomo C.A.;
RT   "Comparative genomics in systemic dimorphic fungi from Ajellomycetaceae.";
RL   Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Cu(2+); Xref=ChEBI:CHEBI:29036;
CC         Evidence={ECO:0000256|ARBA:ARBA00001973};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PGH15646.1}.
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DR   EMBL; PDNB01000023; PGH15646.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2B7Y2D7; -.
DR   STRING; 1447875.A0A2B7Y2D7; -.
DR   OrthoDB; 1658288at2759; -.
DR   Proteomes; UP000223968; Unassembled WGS sequence.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.310.20; -; 1.
DR   Gene3D; 1.10.1280.10; Di-copper center containing domain from catechol oxidase; 1.
DR   InterPro; IPR008922; Di-copper_centre_dom_sf.
DR   InterPro; IPR050316; Tyrosinase/Hemocyanin.
DR   InterPro; IPR041640; Tyrosinase_C.
DR   InterPro; IPR002227; Tyrosinase_Cu-bd.
DR   PANTHER; PTHR11474:SF131; TYROSINASE COPPER-BINDING DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR11474; TYROSINASE FAMILY MEMBER; 1.
DR   Pfam; PF00264; Tyrosinase; 1.
DR   Pfam; PF18132; Tyrosinase_C; 1.
DR   PRINTS; PR00092; TYROSINASE.
DR   SUPFAM; SSF48056; Di-copper centre-containing domain; 1.
DR   PROSITE; PS00497; TYROSINASE_1; 1.
DR   PROSITE; PS00498; TYROSINASE_2; 1.
PE   4: Predicted;
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Monooxygenase {ECO:0000256|ARBA:ARBA00023033};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000223968};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           22..644
FT                   /note="Tyrosinase copper-binding domain-containing protein"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5012699374"
FT   DOMAIN          105..122
FT                   /note="Tyrosinase copper-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS00497"
FT   DOMAIN          297..308
FT                   /note="Tyrosinase copper-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS00498"
FT   REGION          608..644
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        626..644
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   644 AA;  73466 MW;  E627D5F84749A718 CRC64;
     MGVFRWQMLL LLSALLSIAS ATVTIQGVQT GIDEKTGERP ARKDITKLQW SGPEWDLYIQ
     ALKAFQDGPD REDLLSFWKV AGIHGYPYVS WDGVEGTQNA GYCSHGSTLF PVWHRPYLAM
     YEERISHHAQ LIANEYPSIV RGIYQKAAED LRIPYWDWAN DPELPKSVIV PELNINTSEG
     MKTIANPLYN YTLNPTTEQG FPNDPLINFP VTVRNPDQNG VSQYDAIQKT LNANGAFLRI
     QTYQLLASEN NYTVFSTDAL QDRGDDYNNL ENLHGLIHVS VGGNLGHMTY TPWSSYDPLF
     WLHHTNVDRI VALWQAVHPD SYVQPVANLG GDFMKAPGTM EDAKTPFAPF REPSGEFYNA
     ETSRHLAPFG YTYPEIEDWE KTPEELATSV RKQINRLYNR RGDNNQQKRN NGPLTARAAH
     YHSMYKHKRV PNLAEEALED LKEFHFKVKD FFEDLGKFSL LNFIKLGINN MKKQWVINIK
     ANKFALPHAY RIFFFLSEPP EEPCEWPYAS NLIGTFASFA SSMGSPANQT REMYGQVPLS
     HMLAVVKNSR MIFDIEETSV VPLLEKHLEW RVLDLTGKVV DEGELEGDAT GISRGLEITI
     AERDVDALDD DDDERDHFPT PHSWKVHKDI TMKRKESCKS KSKK
//