ID A0A2C6AKQ6_9HYPO Unreviewed; 1755 AA.
AC A0A2C6AKQ6;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 18-JUN-2025, entry version 28.
DE RecName: Full=DNA-directed RNA polymerase subunit {ECO:0000256|RuleBase:RU004279};
DE EC=2.7.7.6 {ECO:0000256|RuleBase:RU004279};
GN ORFNames=CDD83_4508 {ECO:0000313|EMBL:PHH92836.1};
OS Cordyceps sp. RAO-2017.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Cordycipitaceae; Cordyceps.
OX NCBI_TaxID=2004951 {ECO:0000313|EMBL:PHH92836.1, ECO:0000313|Proteomes:UP000221130};
RN [1] {ECO:0000313|Proteomes:UP000221130}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1346 {ECO:0000313|Proteomes:UP000221130};
RA de Bekker C., Evans H.C., Brachmann A., Hughes D.P.;
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:PHH92836.1, ECO:0000313|Proteomes:UP000221130}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1346 {ECO:0000313|EMBL:PHH92836.1,
RC ECO:0000313|Proteomes:UP000221130};
RA De Bekker C., Evans H.C., Brachmann A., Hughes D.P.;
RT "Ant-infecting Ophiocordyceps genomes reveal a high diversity of potential
RT behavioral manipulation genes and a possible major role for enterotoxins.";
RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of
CC DNA into RNA using the four ribonucleoside triphosphates as substrates.
CC {ECO:0000256|RuleBase:RU004279}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) +
CC diphosphate; Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC EC=2.7.7.6; Evidence={ECO:0000256|ARBA:ARBA00048552,
CC ECO:0000256|RuleBase:RU004279};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the RNA polymerase beta' chain family.
CC {ECO:0000256|ARBA:ARBA00006460, ECO:0000256|RuleBase:RU004279}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PHH92836.1}.
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DR EMBL; NJEV01000023; PHH92836.1; -; Genomic_DNA.
DR STRING; 2004951.A0A2C6AKQ6; -.
DR OrthoDB; 270392at2759; -.
DR Proteomes; UP000221130; Unassembled WGS sequence.
DR GO; GO:0005739; C:mitochondrion; IEA:GOC.
DR GO; GO:0005665; C:RNA polymerase II, core complex; IEA:TreeGrafter.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003899; F:DNA-directed RNA polymerase activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006366; P:transcription by RNA polymerase II; IEA:InterPro.
DR CDD; cd02584; RNAP_II_Rpb1_C; 1.
DR CDD; cd02733; RNAP_II_RPB1_N; 1.
DR FunFam; 2.40.40.20:FF:000019; DNA-directed RNA polymerase II subunit RPB1; 1.
DR FunFam; 1.10.132.30:FF:000001; DNA-directed RNA polymerase subunit; 1.
DR FunFam; 1.10.150.390:FF:000001; DNA-directed RNA polymerase subunit; 1.
DR FunFam; 1.10.274.100:FF:000001; DNA-directed RNA polymerase subunit; 1.
DR FunFam; 3.30.1360.140:FF:000001; DNA-directed RNA polymerase subunit; 1.
DR FunFam; 3.30.1490.180:FF:000001; DNA-directed RNA polymerase subunit; 1.
DR FunFam; 4.10.860.120:FF:000003; DNA-directed RNA polymerase subunit; 1.
DR Gene3D; 1.10.132.30; -; 1.
DR Gene3D; 1.10.150.390; -; 1.
DR Gene3D; 2.40.40.20; -; 1.
DR Gene3D; 3.30.1360.140; -; 1.
DR Gene3D; 6.10.250.2940; -; 1.
DR Gene3D; 6.20.50.80; -; 1.
DR Gene3D; 3.30.1490.180; RNA polymerase ii; 1.
DR Gene3D; 4.10.860.120; RNA polymerase II, clamp domain; 2.
DR Gene3D; 1.10.274.100; RNA polymerase Rpb1, domain 3; 1.
DR InterPro; IPR045867; DNA-dir_RpoC_beta_prime.
DR InterPro; IPR000722; RNA_pol_asu.
DR InterPro; IPR000684; RNA_pol_II_repeat_euk.
DR InterPro; IPR006592; RNA_pol_N.
DR InterPro; IPR007080; RNA_pol_Rpb1_1.
DR InterPro; IPR007066; RNA_pol_Rpb1_3.
DR InterPro; IPR042102; RNA_pol_Rpb1_3_sf.
DR InterPro; IPR007083; RNA_pol_Rpb1_4.
DR InterPro; IPR007081; RNA_pol_Rpb1_5.
DR InterPro; IPR007075; RNA_pol_Rpb1_6.
DR InterPro; IPR007073; RNA_pol_Rpb1_7.
DR InterPro; IPR038593; RNA_pol_Rpb1_7_sf.
DR InterPro; IPR044893; RNA_pol_Rpb1_clamp_domain.
DR InterPro; IPR038120; Rpb1_funnel_sf.
DR NCBIfam; NF006336; PRK08566.1; 1.
DR PANTHER; PTHR19376; DNA-DIRECTED RNA POLYMERASE; 1.
DR PANTHER; PTHR19376:SF37; DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1; 1.
DR Pfam; PF04997; RNA_pol_Rpb1_1; 1.
DR Pfam; PF00623; RNA_pol_Rpb1_2; 1.
DR Pfam; PF04983; RNA_pol_Rpb1_3; 1.
DR Pfam; PF05000; RNA_pol_Rpb1_4; 1.
DR Pfam; PF04998; RNA_pol_Rpb1_5; 1.
DR Pfam; PF04992; RNA_pol_Rpb1_6; 1.
DR Pfam; PF04990; RNA_pol_Rpb1_7; 1.
DR SMART; SM00663; RPOLA_N; 1.
DR SUPFAM; SSF64484; beta and beta-prime subunits of DNA dependent RNA-polymerase; 1.
DR PROSITE; PS00115; RNA_POL_II_REPEAT; 2.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW DNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022478,
KW ECO:0000256|RuleBase:RU004279}; Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695,
KW ECO:0000256|RuleBase:RU004279}; Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000221130};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU004279};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU004279};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 244..550
FT /note="RNA polymerase N-terminal"
FT /evidence="ECO:0000259|SMART:SM00663"
FT REGION 1559..1755
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1561..1573
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1579..1591
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1603..1646
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1658..1677
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1684..1701
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1712..1740
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1743..1755
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1755 AA; 193217 MW; C6BD20FC3479D77E CRC64;
MANLYFTHSS APLKTVEEIQ FGLMSPEEIK NMSVAHILYP ETMEENKTKP RDGGLNDPLL
GSIDRQFKCK TCTQAMGECP GHFGHIELAK PVYHPGFIKK VKKILEIVCH NCSKVLADTS
DPEFVTAINT RDPKLRFNRV WTVCKKKRRC ENEDRQSKDK DEEFAPGMKL PNAVDNHGGC
GNVQPAVRQA ALQLKAAFEV AQEDGPKRKE TVPITPEMAH GILRRISEDD LRNMGLNCDY
ARPEWMIVTV LPVPPPPVRP SISMDGTGTG MRNEDDLTYK LGDIIRANGN VKQAIREGSP
QHIARDFEEL LQYHVATYMD NDIAGQPRAL QKSGRPVKAI RARLKGKEGR LRGNLMGKRV
DFSARTVITG DANISLHEVG VPRSIARTLT YPETVTPYNI GKLHQLVENG PNEHPGAKYV
IRSDGTRIDL RHHRRAAQIS LEYGWKVERH LMDGDYIIFN RQPSLHKESM MGHRVRVMPY
STFRLNLSVT SPYNADFDGD EMNLHVPQSE ETRAEIKELC LVPNNIVSPQ KNGPLMGIVQ
DSLAGAYKLC RRDTFIDKEM VMNLMLWVPH WDGVIPPPAI LKPRPRWTGK QIISMVIPQE
ISLHTPEGDS DIPLKDTGLL IQSGQLMYGL LKKKNIGSAA GGIVHLCYNE LGPDGAMAFL
NGVQQVVTYW LLHNGHSIGI GDTVPDKQTI EKVQVHIDVQ KAEVARLTAQ ATANELEALP
GMNVRATFEN KVSMALNQAR DQAGTTTQKS LKDSNNAVTM AESGSKGSSI NISQMTALVG
QQIVEGKRIP FGFKYRTLPH FTKDDYSPEA RGFVENSYLR GLTPSEFFFH AMAGREGLID
TAVKTAETGY IQRRLVKALE DLSARYDGTV RNSLGDIVQF LYGEDGLDAM CIEKQKLGVL
KMSDPAFEKK YRLDLANPPE WFRTDYEYGN ELTGDKASMA LLDEEWEALL RDRREVRLIN
KSKMGEEMMQ LPLNIGRIIE TAKRVFNVKA TDRSNLRPSD VIPAVQKVLA NMKIVRGPDP
ISWEADANAT ILIKALLRSR LAFKEIVKEH RLNRLAFDHV LGELQNRWDR SFVSPGEMVG
VLAAQSIGEP ATQMTLNTFH FAGVSSKNVT LGVPRLKEIL NLAKDIKTPS MAVYLNTTLG
KQEEAKKLRS MVEYTNLRSI TSVTEIYYDP DIQGTSIAED VDMVESYFLI PDDSQDTLEQ
QSRWLLRITL DRQKLLDKEI KIDDVAQRIK EEYPHDLGII FSDNNADEQV IRIRTIRQDD
EKDENGEKRI EDDVMLKRLE SHLLDTLTLR GVPGIERAFL TKGTRLVEGP DGAELAIKDD
PRCTQWYLDT SGSALREVLA VDGVDPTRTY TNDLWQIVEV FGIEAARSAL VKELTNVLAF
DGSYVNHRHI ALLTDVMTYR GTISAVTRHG INRADTGALM RCSFEETVEI LLEAAATGEL
DDCRGISENV MLGQMAPMGT GNFDVLLDPK MLETVISDNS RMGLMPGMPT KDGEAEGAAT
PYDTGSPMAD SGYMSLSSPA AGNFSPIQGA GSETPAGFGT EYGGIGFGGI GSMSPYARGA
TSPFSTSPTS PFSGMGGYSP SSPNAGYSPT SPLIDGGGGR YATSPSFSPS SPSFSPTSPM
LRPTSPASPN YSPTSPSYSP ASPSSPRHYS PTSPAQFNSP TSPSYSPASP NYSPASPNLH
GAGPTSPSYS PASPSWSPTS PEAYSPTSPG FSRSPGTQQS PTSPSYSPTS PSFSPRTPGP
GNSGNQYSPN SPAND
//
