ID A0A2D1U4D2_9SPHI Unreviewed; 786 AA.
AC A0A2D1U4D2;
DT 31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT 31-JAN-2018, sequence version 1.
DT 18-JUN-2025, entry version 29.
DE RecName: Full=peptidoglycan glycosyltransferase {ECO:0000256|ARBA:ARBA00044770};
DE EC=2.4.99.28 {ECO:0000256|ARBA:ARBA00044770};
GN Name=pbpC {ECO:0000313|EMBL:ATP56394.1};
GN ORFNames=CPT03_07865 {ECO:0000313|EMBL:ATP56394.1};
OS Pedobacter ginsengisoli.
OC Bacteria; Pseudomonadati; Bacteroidota; Sphingobacteriia;
OC Sphingobacteriales; Sphingobacteriaceae; Pedobacter.
OX NCBI_TaxID=363852 {ECO:0000313|EMBL:ATP56394.1, ECO:0000313|Proteomes:UP000223749};
RN [1] {ECO:0000313|EMBL:ATP56394.1, ECO:0000313|Proteomes:UP000223749}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=T01R-27 {ECO:0000313|EMBL:ATP56394.1,
RC ECO:0000313|Proteomes:UP000223749};
RA Weon H.-Y., Lee S.A., Sang M.K., Song J.;
RT "Whole genome of Pedobacter ginsengisoli T01R-27 isolated from tomato
RT rhizosphere.";
RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-
CC Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-
CC (1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-
CC cis-undecaprenyl diphosphate = [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-
CC D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans,octa-cis-undecaprenyl
CC diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+);
CC Xref=Rhea:RHEA:23708, Rhea:RHEA-COMP:9602, Rhea:RHEA-COMP:9603,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:58405, ChEBI:CHEBI:60033,
CC ChEBI:CHEBI:78435; EC=2.4.99.28;
CC Evidence={ECO:0000256|ARBA:ARBA00049902};
CC -!- PATHWAY: Cell wall biogenesis; peptidoglycan biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004752}.
CC -!- SIMILARITY: In the C-terminal section; belongs to the transpeptidase
CC family. {ECO:0000256|ARBA:ARBA00007090}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the
CC glycosyltransferase 51 family. {ECO:0000256|ARBA:ARBA00007739}.
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DR EMBL; CP024091; ATP56394.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2D1U4D2; -.
DR KEGG; pgs:CPT03_07865; -.
DR OrthoDB; 9766909at2; -.
DR Proteomes; UP000223749; Chromosome.
DR GO; GO:0030288; C:outer membrane-bounded periplasmic space; IEA:TreeGrafter.
DR GO; GO:0004180; F:carboxypeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR GO; GO:0008955; F:peptidoglycan glycosyltransferase activity; IEA:InterPro.
DR GO; GO:0009252; P:peptidoglycan biosynthetic process; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 1.10.3810.10; Biosynthetic peptidoglycan transglycosylase-like; 1.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR001264; Glyco_trans_51.
DR InterPro; IPR050396; Glycosyltr_51/Transpeptidase.
DR InterPro; IPR023346; Lysozyme-like_dom_sf.
DR InterPro; IPR011815; PBP_1c.
DR InterPro; IPR009647; PBP_C.
DR InterPro; IPR036950; PBP_transglycosylase.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR NCBIfam; TIGR02073; PBP_1c; 1.
DR PANTHER; PTHR32282; BINDING PROTEIN TRANSPEPTIDASE, PUTATIVE-RELATED; 1.
DR PANTHER; PTHR32282:SF15; PENICILLIN-BINDING PROTEIN 1C; 1.
DR Pfam; PF06832; BiPBP_C; 1.
DR Pfam; PF00912; Transgly; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF53955; Lysozyme-like; 1.
PE 3: Inferred from homology;
KW Carboxypeptidase {ECO:0000256|ARBA:ARBA00022645};
KW Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022670};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000223749};
KW Transferase {ECO:0000256|ARBA:ARBA00022676}.
FT DOMAIN 51..210
FT /note="Glycosyl transferase family 51"
FT /evidence="ECO:0000259|Pfam:PF00912"
FT DOMAIN 293..573
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
FT DOMAIN 695..771
FT /note="Penicillin-binding C-terminal"
FT /evidence="ECO:0000259|Pfam:PF06832"
SQ SEQUENCE 786 AA; 88616 MW; 174299EF035BAA2F CRC64;
MTDVVFLILL LIFLFSLPSK LFVSPTSYVV EASNGDLLSA SIAKDGQWRF PVADNIPEKF
AQCLVAFEDK RFYYHPGVDP IAMARAMRQN FKAKSVISGG STISMQVIRL SRRESRTVWQ
KLIEIILAIR LEASYSKKEI LKLYAGNAPF GSNVVGLDAA AWRYFGRSAE SLSWGEMATL
AVLPNSPSLV HPGKNSPRLI KKRNDLLDKL AVLKIIDQST ANLSKLEPIP GKPQQLPQNA
PHLLNRFKAE RSALKTGSTR ITSTLDYDLQ LRVSSLLKRY NNRYRANDIN NIAALVLDVK
KGTVLSYVGN IYQPENTELE SHVDMIKAPR SPGSTLKPIL YASMLNDGFI LPKTLIADIP
TQIGGYSPQN YDMGYDGAIQ ADRALSRSLN IPAVKMLQNY KYQRFYDKLK QLGFTTLNKP
ADHYGLSLIL GGSEVTMWDL ARTYMGMART LNHFNDYKGR YNPHDYDEPL YVNEQRDKRF
DEFETEVNSA IDHGSIWNAF NAMEELMRPG EEGLWEQFSS SQRLAWKTGT SFGFRDAWAV
GLNPNYVVCV WVGNADGEGR PGLTGIDAAA PVMFDIFKQL PVVKWFKTPT SKLKKIVVCK
ESGYKAGEYC TDKVIQLVSP AGEKTGLCPY HKMVHLDRTG TYRVTDECEA PSAMVHKSWF
ILPPSMEYYY KIKNSDYKEL PPFKPGCGDA GNNFVMEMIY PRNYATVYIP VEFDGTRGKI
VLNATHRNAN AKIYWHIDNE YVATTKNYHQ LAVSPAPGKH ILTLVDENGE RLVQHFTVLE
KEKEKN
//
