ID A0A2H0ZM95_CANAR Unreviewed; 246 AA.
AC A0A2H0ZM95;
DT 31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT 31-JAN-2018, sequence version 1.
DT 08-OCT-2025, entry version 29.
DE RecName: Full=Pru domain-containing protein {ECO:0000259|PROSITE:PS51917};
GN ORFNames=B9J08_003357 {ECO:0000313|EMBL:PIS51760.1}, B9J08_01218
GN {ECO:0000313|EMBL:KAK8442869.1};
OS Candidozyma auris (Yeast) (Candida auris).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Pichiomycetes;
OC Metschnikowiaceae; Candidozyma.
OX NCBI_TaxID=498019 {ECO:0000313|EMBL:PIS51760.1};
RN [1] {ECO:0000313|EMBL:PIS51760.1, ECO:0000313|Proteomes:UP000230249}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B8441 {ECO:0000313|EMBL:PIS51760.1,
RC ECO:0000313|Proteomes:UP000230249};
RX PubMed=27988485; DOI=.1093/cid/ciw691;
RA Lockhart S.R., Etienne K.A., Vallabhaneni S., Farooqi J., Chowdhary A.,
RA Govender N.P., Colombo A.L., Calvo B., Cuomo C.A., Desjardins C.A.,
RA Berkow E.L., Castanheira M., Magobo R.E., Jabeen K., Asghar R.J.,
RA Meis J.F., Jackson B., Chiller T., Litvintseva A.P.;
RT "Simultaneous emergence of multidrug-resistant Candida auris on 3
RT continents confirmed by whole-genome sequencing and epidemiological
RT analyses.";
RL Clin. Infect. Dis. 64:134-140(2017).
RN [2] {ECO:0000313|EMBL:PIS51760.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=B8441 {ECO:0000313|EMBL:PIS51760.1};
RA Munoz J.F., Gade L.G., Chow N.A., Litvintseva A.P., Loparev V.N.,
RA Cuomo C.A.;
RT "Candida auris genome assembly and annotation.";
RL Submitted (NOV-2017) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:KAK8442869.1, ECO:0000313|Proteomes:UP000230249}
RP GENOME REANNOTATION.
RC STRAIN=B8441 {ECO:0000313|EMBL:KAK8442869.1,
RC ECO:0000313|Proteomes:UP000230249};
RX PubMed=30559369; DOI=.1038/s41467-018-07779-6;
RA Munoz J.F., Gade L., Chow N.A., Loparev V.N., Juieng P., Berkow E.L.,
RA Farrer R.A., Litvintseva A.P., Cuomo C.A.;
RT "Genomic insights into multidrug-resistance, mating and virulence in
RT Candida auris and related emerging species.";
RL Nat. Commun. 9:5346-5346(2018).
RN [4] {ECO:0000313|EMBL:KAK8442869.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=B8441 {ECO:0000313|EMBL:KAK8442869.1};
RA Cauldron N.C., Shea T., Cuomo C.A.;
RT "Improved genome assembly of Candida auris strain B8441 and annotation of
RT B11205.";
RL Submitted (MAR-2024) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PIS51760.1}.
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DR EMBL; PEKT03000001; KAK8442869.1; -; Genomic_DNA.
DR EMBL; PEKT02000007; PIS51760.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2H0ZM95; -.
DR STRING; 498019.A0A2H0ZM95; -.
DR VEuPathDB; FungiDB:B9J08_003357; -.
DR VEuPathDB; FungiDB:CJI96_0001894; -.
DR VEuPathDB; FungiDB:CJI97_003432; -.
DR VEuPathDB; FungiDB:CJJ07_005453; -.
DR VEuPathDB; FungiDB:CJJ09_000748; -.
DR VEuPathDB; FungiDB:QG37_01877; -.
DR OMA; CNTGRVI; -.
DR OrthoDB; 340431at2759; -.
DR Proteomes; UP000230249; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0008541; C:proteasome regulatory particle, lid subcomplex; IEA:TreeGrafter.
DR GO; GO:0061133; F:endopeptidase activator activity; IEA:TreeGrafter.
DR GO; GO:0070628; F:proteasome binding; IEA:TreeGrafter.
DR Gene3D; 1.10.2020.20; -; 1.
DR Gene3D; 2.30.29.70; Proteasomal ubiquitin receptor Rpn13/ADRM1; 1.
DR InterPro; IPR006773; Rpn13/ADRM1.
DR InterPro; IPR044868; Rpn13/ADRM1_Pru.
DR InterPro; IPR038633; Rpn13/ADRM1_Pru_sf.
DR InterPro; IPR038108; RPN13_DEUBAD_sf.
DR PANTHER; PTHR12225; ADHESION REGULATING MOLECULE 1 110 KDA CELL MEMBRANE GLYCOPROTEIN; 1.
DR PANTHER; PTHR12225:SF0; PROTEASOMAL UBIQUITIN RECEPTOR ADRM1; 1.
DR Pfam; PF04683; Rpn13_ADRM1_Pru; 1.
DR PROSITE; PS51917; PRU; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Proteasome {ECO:0000256|ARBA:ARBA00022942};
KW Reference proteome {ECO:0000313|Proteomes:UP000230249}.
FT DOMAIN 1..125
FT /note="Pru"
FT /evidence="ECO:0000259|PROSITE:PS51917"
FT REGION 125..147
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 131..146
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 246 AA; 27717 MW; 6FAB5A1329BE4AD7 CRC64;
MSKTIKFNAG KVQYDEETKK CTPLPHKGQV VIKPSEEEGC FDFRWSPKGN SGNVEVDERL
IIPGDMTFKQ VKSCNTGRVI ALTFVSSGDR SLYWLQDVGD VEEYGQWTEK DQELLKSLQA
LVEEEEEPVE ETVKQESKEE PQREQTRAPI TSIDDVLTVD VIDKHLTSLS DKELVEKYGD
LLPEGVKPTR EEIIRVVRNG FFQQANKELS STILNNGVGQ ILASSLGYEY QGEGIDAFLE
GLRKAK
//
