ID A0A2H5W9A7_UNCXX Unreviewed; 786 AA.
AC A0A2H5W9A7;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 18-JUN-2025, entry version 28.
DE RecName: Full=peptidoglycan glycosyltransferase {ECO:0000256|ARBA:ARBA00044770};
DE EC=2.4.99.28 {ECO:0000256|ARBA:ARBA00044770};
GN Name=pbpC {ECO:0000313|EMBL:GBC85532.1};
GN ORFNames=HRbin11_01982 {ECO:0000313|EMBL:GBC85532.1};
OS bacterium HR11.
OC Bacteria.
OX NCBI_TaxID=2035406 {ECO:0000313|EMBL:GBC85532.1, ECO:0000313|Proteomes:UP000236429};
RN [1] {ECO:0000313|Proteomes:UP000236429}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Kato S., Suzuki K.;
RT "Metaegenomics of thermophilic ammonia-oxidizing enrichment culture.";
RL Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-
CC Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-
CC (1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-
CC cis-undecaprenyl diphosphate = [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-
CC D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans,octa-cis-undecaprenyl
CC diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+);
CC Xref=Rhea:RHEA:23708, Rhea:RHEA-COMP:9602, Rhea:RHEA-COMP:9603,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:58405, ChEBI:CHEBI:60033,
CC ChEBI:CHEBI:78435; EC=2.4.99.28;
CC Evidence={ECO:0000256|ARBA:ARBA00049902};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GBC85532.1}.
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DR EMBL; BEHN01000019; GBC85532.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2H5W9A7; -.
DR Proteomes; UP000236429; Unassembled WGS sequence.
DR GO; GO:0030288; C:outer membrane-bounded periplasmic space; IEA:TreeGrafter.
DR GO; GO:0004180; F:carboxypeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR GO; GO:0008955; F:peptidoglycan glycosyltransferase activity; IEA:InterPro.
DR GO; GO:0009252; P:peptidoglycan biosynthetic process; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 1.10.3810.10; Biosynthetic peptidoglycan transglycosylase-like; 1.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR001264; Glyco_trans_51.
DR InterPro; IPR050396; Glycosyltr_51/Transpeptidase.
DR InterPro; IPR023346; Lysozyme-like_dom_sf.
DR InterPro; IPR011815; PBP_1c.
DR InterPro; IPR009647; PBP_C.
DR InterPro; IPR036950; PBP_transglycosylase.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR NCBIfam; TIGR02073; PBP_1c; 1.
DR PANTHER; PTHR32282; BINDING PROTEIN TRANSPEPTIDASE, PUTATIVE-RELATED; 1.
DR PANTHER; PTHR32282:SF15; PENICILLIN-BINDING PROTEIN 1C; 1.
DR Pfam; PF06832; BiPBP_C; 1.
DR Pfam; PF00912; Transgly; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF53955; Lysozyme-like; 1.
PE 4: Predicted;
KW Carboxypeptidase {ECO:0000256|ARBA:ARBA00022645};
KW Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022670};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Transferase {ECO:0000256|ARBA:ARBA00022676}.
FT DOMAIN 75..242
FT /note="Glycosyl transferase family 51"
FT /evidence="ECO:0000259|Pfam:PF00912"
FT DOMAIN 321..537
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
FT DOMAIN 697..778
FT /note="Penicillin-binding C-terminal"
FT /evidence="ECO:0000259|Pfam:PF06832"
SQ SEQUENCE 786 AA; 86070 MW; ADB9DB5757548AA8 CRC64;
MTSSSVSASG PARRDALPDG FRAFRRRWPG LLVAWAGMGV AALGRAPLPA GVHAPYSQVV
YDRRGEVLRI FLTPDEKWRI EARLDEIDPL LVRATVCFED RFFWFHPGVN PLAVLRAAWQ
NVRAGRIVSG GSTLSMQSAR IVEPRPRTWR AKLVEALRAF QYELRLGKRR ILELYLSRAP
YGGNLEGVTA AALAYFGRPP RRLTPAEVAF LVSLPQAPVS RSLLRASPSE VRKARDRVLA
RMRACGLLSE AAYRSALRES VPTGLRPMPA RALHATDYLH ALFPQAARIR STLDADVQRT
VESLVQAYRP VVYRNGATNV SVVVIENSTR KVRALVGSLD YWDEAHDGQV PGFLAPRSPG
SALKPFLYAL ALQKGVITTE TLLEDYPTSI RGYQPVNFSG TFRGLVRAEE ALAYSLNVPF
VHLLRRTGFR DFLRLLERGG IDVRSGVDYG LSVITGALEV RLLDLTNLYV TLARDGRHGP
PVLVEDASRP ETERRLLHPG AVVLTRRALA LRDRPDAPHL RAVTLPRATV YWKTGTSWGR
RDAWSVGFHA GYTVGVWVGN FSGEGAEGIV GGELAAPLMF DVLNALPAPA PELRPPPDAD
LTRVPVCPFS GERPTDACPG VRWVLAVRDA APLRACPYHR RLLVERDSGR RMCPWRSYAP
DEVTARVFTV LPPLAAAFLG MPASTEPPPS ESCGPPEAAP ELRILSPLDG ATYLLSADVR
GSGGIPLRAV TPAPDRRIFW FVNDRFVGST ASGGVQVIRL PPGPVTVVAV DSTGRADRAH
LHVLPP
//
