ID A0A2I2Z2A9_GORGO Unreviewed; 445 AA.
AC A0A2I2Z2A9;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 28-JAN-2026, entry version 32.
DE RecName: Full=Integrin beta-like protein 1 {ECO:0000256|ARBA:ARBA00068076};
GN Name=ITGBL1 {ECO:0000313|Ensembl:ENSGGOP00000041120.1};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000041120.1, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000041120.1, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000041120.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (AUG-2025) to UniProtKB.
RN [4] {ECO:0000313|Ensembl:ENSGGOP00000041120.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2025) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
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DR EMBL; CABD030090648; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030090649; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030090650; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030090651; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030090652; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030090653; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030090654; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2I2Z2A9; -.
DR Ensembl; ENSGGOT00000052354.1; ENSGGOP00000041120.1; ENSGGOG00000006808.4.
DR GeneTree; ENSGT01150000286919; -.
DR Proteomes; UP000001519; Chromosome 13.
DR Bgee; ENSGGOG00000006808; Expressed in heart and 6 other cell types or tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-ARBA.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-ARBA.
DR FunFam; 2.10.25.10:FF:000249; Integrin subunit beta like 1; 1.
DR FunFam; 2.10.25.10:FF:000374; Integrin subunit beta like 1; 1.
DR FunFam; 2.10.25.10:FF:000384; Integrin subunit beta like 1; 1.
DR FunFam; 2.10.25.10:FF:000042; Integrin subunit beta-like 1; 4.
DR FunFam; 2.10.25.10:FF:000175; Integrin subunit beta-like 1; 1.
DR Gene3D; 2.10.25.10; Laminin; 9.
DR InterPro; IPR000742; EGF.
DR InterPro; IPR013111; EGF_extracell.
DR InterPro; IPR057073; EGF_integrin_2.
DR InterPro; IPR015812; Integrin_bsu.
DR InterPro; IPR057243; Integrin_I-EGF_CS.
DR PANTHER; PTHR10082; INTEGRIN BETA SUBUNIT; 1.
DR PANTHER; PTHR10082:SF60; INTEGRIN BETA-PS; 1.
DR Pfam; PF07974; EGF_2; 5.
DR Pfam; PF23105; EGF_integrin; 1.
DR SMART; SM00181; EGF; 4.
DR SUPFAM; SSF57196; EGF/Laminin; 5.
DR PROSITE; PS00243; I_EGF_1; 5.
DR PROSITE; PS52047; I_EGF_2; 7.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..445
FT /note="Integrin beta-like protein 1"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014174056"
FT DOMAIN 135..168
FT /note="EGF-like"
FT /evidence="ECO:0000259|SMART:SM00181"
FT DOMAIN 181..221
FT /note="EGF-like"
FT /evidence="ECO:0000259|SMART:SM00181"
FT DOMAIN 226..262
FT /note="EGF-like"
FT /evidence="ECO:0000259|SMART:SM00181"
FT DOMAIN 318..350
FT /note="EGF-like"
FT /evidence="ECO:0000259|SMART:SM00181"
SQ SEQUENCE 445 AA; 48532 MW; 4DE069A591BBA42F CRC64;
MRPPGFRNFL LLASSLLFAG LSAVPQSFSP SLRSWPGAAC RLSRAESERR CRAPGQPPGA
ALCHGRGRCD CGVCICHVTE PGMFFGPLCE CHEWVCETYD GSTCAGTCHC GRCKCDNSDG
SGLVYGKFCE CDDRECIDDE TEEICGGHGK CYCGNCYCKA GWHGDKCEFQ CDITPWESKR
RCTSPDGKIC SNRGTCVCGE CTCHDVDPTG DWGDIHGDTC ECDERDCRAV YDRYSDDFCS
GHGQCNCGRC DCKAGWYGKK CEHPQSCTLS ADESIRKCQG SSDLPCSGRG KCECGKCTCY
PPGDRRVYGK TCECDDRRCE DLDGVVCGGH GTCSCGRCVC ERGWFGKLCQ HPRKCNMTEE
QSKNLCESAD GILCSGKGSC HCGKCICSAE EWYISGEFCD CDDRDCDKHD GLICTGNGIC
SCGNCECWDG WNGNACEIWL GSEYP
//
