ID A0A2I3T6M4_PANTR Unreviewed; 561 AA.
AC A0A2I3T6M4;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 10-JUN-2026, entry version 30.
DE RecName: Full=Outer dense fiber protein 2 {ECO:0000256|ARBA:ARBA00040458};
DE AltName: Full=Cenexin {ECO:0000256|ARBA:ARBA00041830};
DE AltName: Full=Outer dense fiber of sperm tails protein 2 {ECO:0000256|ARBA:ARBA00043200};
GN Name=ODF2 {ECO:0000313|Ensembl:ENSPTRP00000084842.1,
GN ECO:0000313|VGNC:VGNC:4815};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000084842.1, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000084842.1, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000084842.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JAN-2026) to UniProtKB.
CC -!- FUNCTION: Seems to be a major component of sperm tail outer dense
CC fibers (ODF). ODFs are filamentous structures located on the outside of
CC the axoneme in the midpiece and principal piece of the mammalian sperm
CC tail and may help to maintain the passive elastic structures and
CC elastic recoil of the sperm tail. May have a modulating influence on
CC sperm motility. Functions as a general scaffold protein that is
CC specifically localized at the distal/subdistal appendages of mother
CC centrioles. Component of the centrosome matrix required for the
CC localization of PLK1 and NIN to the centrosomes. Required for the
CC formation and/or maintenance of normal CETN1 assembly.
CC {ECO:0000256|ARBA:ARBA00037601}.
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium, flagellum
CC {ECO:0000256|ARBA:ARBA00004230}. Cytoplasm, cytoskeleton, microtubule
CC organizing center, centrosome, centriole
CC {ECO:0000256|ARBA:ARBA00004114}. Cytoplasm, cytoskeleton, spindle pole
CC {ECO:0000256|ARBA:ARBA00004647}.
CC -!- SIMILARITY: Belongs to the ODF2 family.
CC {ECO:0000256|ARBA:ARBA00009316}.
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DR EMBL; AACZ04069103; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2I3T6M4; -.
DR Ensembl; ENSPTRT00000094097.1; ENSPTRP00000084842.1; ENSPTRG00000021430.6.
DR VGNC; VGNC:4815; ODF2.
DR GeneTree; ENSGT00530000063497; -.
DR Proteomes; UP000002277; Chromosome 9.
DR Bgee; ENSPTRG00000021430; Expressed in testis and 20 other cell types or tissues.
DR GO; GO:0005814; C:centriole; IEA:UniProtKB-SubCell.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0031514; C:motile cilium; IEA:UniProtKB-SubCell.
DR GO; GO:0000922; C:spindle pole; IEA:UniProtKB-SubCell.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
DR InterPro; IPR026099; ODF2/BCAP.
DR PANTHER; PTHR23162; OUTER DENSE FIBER OF SPERM TAILS 2; 1.
DR PANTHER; PTHR23162:SF8; OUTER DENSE FIBER PROTEIN 2; 1.
DR Pfam; PF27605; ODF2_C; 1.
DR Pfam; PF27578; ODF2_N; 1.
PE 3: Inferred from homology;
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW Flagellum {ECO:0000256|ARBA:ARBA00022846};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW Spermatogenesis {ECO:0000256|ARBA:ARBA00022871}.
FT REGION 25..47
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 296..317
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 56..121
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 426..534
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 561 AA; 64958 MW; 2294657CB03EE21F CRC64;
VQDQPGQHGE TPSLLKIQKF ASDLPTLASQ RPPFSGPCLG PPAQVKMQKG ERQMAKRFLE
ERKEELEEVA HELAETEHEN TVLRHNIERM KEEKDFTILQ KKHLQQEKEC LMSKLVEAEM
DGAAAAKQVM ALKDTIGKLK TEKQMTCTDI NTLTRQKELL LQKLSTFEET NRTLRDLLRE
QHCKEDSERL MEQQGALLKR LAEADSEKAR LLLLLQDKDK EVEELLQEIQ CEKAQAKTAS
ELSKSMESMR GHLQAQLRSK EAENSRLCMQ IKNLERSGNQ HKAEVEAIME QLKELKQKGD
RDKESLKKAI RAQKERAEKS EEYAEQLHVQ LADKDLYVAE ALSTLESWRS RYNQVVKEKG
DLELEIIVLN DRVTDLVNQQ QTLEEKMRED RDSLVERLHR QTAEYSAFKL ENERLKASFA
PMEDKLNQAH LEVQQLKASV KNYEGMIDNY KSQVMKTRLE ADEVAAQLER CDKENKILKD
EMNKEIEAAR RQFQSQLADL QQLPDILKIT EAKLAECQDQ LQGYERKNID LTAIISDLRS
RVRDWQKGSH ELTRAGARIP R
//
