ID A0A2I4BJM4_AUSLI Unreviewed; 548 AA.
AC A0A2I4BJM4;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 28-JAN-2026, entry version 35.
DE SubName: Full=Suppressor of cytokine signaling 9 {ECO:0000313|RefSeq:XP_013867923.1};
GN Name=socs9 {ECO:0000313|RefSeq:XP_013867923.1};
OS Austrofundulus limnaeus (Annual killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Rivulidae;
OC Austrofundulus.
OX NCBI_TaxID=52670 {ECO:0000313|Proteomes:UP000192220, ECO:0000313|RefSeq:XP_013867923.1};
RN [1] {ECO:0000313|RefSeq:XP_013867923.1}
RP IDENTIFICATION.
RC STRAIN=Quisiro {ECO:0000313|RefSeq:XP_013867923.1};
RC TISSUE=Liver {ECO:0000313|RefSeq:XP_013867923.1};
RG RefSeq;
RL Submitted (AUG-2025) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
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DR RefSeq; XP_013867923.1; XM_014012469.1.
DR AlphaFoldDB; A0A2I4BJM4; -.
DR STRING; 52670.A0A2I4BJM4; -.
DR KEGG; alim:106520389; -.
DR CTD; 100003691; -.
DR InParanoid; A0A2I4BJM4; -.
DR OrthoDB; 8820570at2759; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000192220; Unplaced.
DR GO; GO:0005942; C:phosphatidylinositol 3-kinase complex; IEA:TreeGrafter.
DR GO; GO:0046935; F:1-phosphatidylinositol-3-kinase regulator activity; IEA:TreeGrafter.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:TreeGrafter.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR FunFam; 3.30.505.10:FF:000028; Suppressor of cytokine signaling 5; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR022252; SOCS4/SOCS5_dom.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10155:SF18; SUPPRESSOR OF CYTOKINE SIGNALING 9 ISOFORM X1; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF12610; SOCS; 1.
DR Pfam; PF07525; SOCS_box; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00253; SOCS; 1.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF158235; SOCS box-like; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50225; SOCS; 1.
PE 4: Predicted;
KW Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW Reference proteome {ECO:0000313|Proteomes:UP000192220};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191};
KW Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 396..491
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 486..535
FT /note="SOCS box"
FT /evidence="ECO:0000259|PROSITE:PS50225"
FT REGION 1..62
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 156..177
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9..18
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 25..35
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 38..47
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 164..177
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 548 AA; 61302 MW; 55ACC3F1DF435D59 CRC64;
MSLPNESGNR GKDRERGARP KVRQSRSEER RDAGGGRKNG KVKKKGVCLH ETAAERPVSD
GFEYGELLSE LEARSQNTSS PLKESWRWQG LDVAGSLLGQ GVTAKASLVT VSSATDLPAL
NETDGRGSSA SRSLRQKIQD AMGQCFPIKT HSAAASAPPQ QTFSSSASCA PSSSSSSSRR
KIHLSELMLD DCPFPVGSEL AQKWYLIKQH TAPITQSPLL DSAVVCSAPT SAMAASVEDV
DDKLRERRRI SIEQGVEPPP NAEIHTFEVT AQINPLYKHG PKLAHGMNEL AETDRTSVHQ
QQQLLLQRQE QHQLLLQSCL DTLDEVVASA SASVRAADMS SESLVDPEEK TTNLTSRALR
PETEIQKAHE GYRIHTQIDY IHCLVPDLLQ ITNLPCYWGV MDRYEAETLL EGKPEGTFLL
RDSAQEDYLF SVSFRRYGRS LHARIEQWNH NFSFDVHDPS VFHAPTVTGL LEHYKDPNSC
MFFEPLLSNP IHRTHPFSLQ HVCRAVISSC TTYDGINMLP IPNALKKHLK EYHYKQRVRV
RRMDTWWE
//
