ID A0A2I4D826_AUSLI Unreviewed; 379 AA.
AC A0A2I4D826;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 28-JAN-2026, entry version 36.
DE SubName: Full=Forkhead box protein F1 {ECO:0000313|RefSeq:XP_013888393.1};
GN Name=foxf1 {ECO:0000313|RefSeq:XP_013888393.1};
OS Austrofundulus limnaeus (Annual killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Rivulidae;
OC Austrofundulus.
OX NCBI_TaxID=52670 {ECO:0000313|Proteomes:UP000192220, ECO:0000313|RefSeq:XP_013888393.1};
RN [1] {ECO:0000313|RefSeq:XP_013888393.1}
RP IDENTIFICATION.
RC STRAIN=Quisiro {ECO:0000313|RefSeq:XP_013888393.1};
RC TISSUE=Liver {ECO:0000313|RefSeq:XP_013888393.1};
RG RefSeq;
RL Submitted (AUG-2025) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00089}.
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DR RefSeq; XP_013888393.1; XM_014032939.1.
DR AlphaFoldDB; A0A2I4D826; -.
DR FunCoup; A0A2I4D826; 55.
DR STRING; 52670.A0A2I4D826; -.
DR GeneID; 106535830; -.
DR KEGG; alim:106535830; -.
DR CTD; 2294; -.
DR InParanoid; A0A2I4D826; -.
DR OrthoDB; 5954824at2759; -.
DR Proteomes; UP000192220; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:TreeGrafter.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:TreeGrafter.
DR GO; GO:0009887; P:animal organ morphogenesis; IEA:TreeGrafter.
DR GO; GO:0048731; P:system development; IEA:UniProtKB-ARBA.
DR CDD; cd20049; FH_FOXF1; 1.
DR FunFam; 1.10.10.10:FF:000071; Forkhead box F1; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR001766; Fork_head_dom.
DR InterPro; IPR051770; Forkhead_box_regulator.
DR InterPro; IPR018122; TF_fork_head_CS_1.
DR InterPro; IPR030456; TF_fork_head_CS_2.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR46262; FORKHEAD BOX PROTEIN BINIOU; 1.
DR PANTHER; PTHR46262:SF1; FORKHEAD BOX PROTEIN F1; 1.
DR Pfam; PF00250; Forkhead; 1.
DR PRINTS; PR00053; FORKHEAD.
DR SMART; SM00339; FH; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS00657; FORK_HEAD_1; 1.
DR PROSITE; PS00658; FORK_HEAD_2; 1.
DR PROSITE; PS50039; FORK_HEAD_3; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00089};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00089}; Reference proteome {ECO:0000313|Proteomes:UP000192220}.
FT DOMAIN 53..147
FT /note="Fork-head"
FT /evidence="ECO:0000259|PROSITE:PS50039"
FT DNA_BIND 53..147
FT /note="Fork-head"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00089"
FT REGION 1..51
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 288..310
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..22
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 379 AA; 41294 MW; AA187D95CF57A014 CRC64;
MTAEVQQPPA QTPAQSSPMS APEKPHGQTV VMETASSTTK TKKTNAGIRR PEKPPYSYIA
LIVMAIQSSP TKRLTLSEIY QFLQSRFPFF RGSYQGWKNS VRHNLSLNEC FIKLPKGLGR
PGKGHYWTID PASEFMFEEG SFRRRPRGFR RKCQALKPMY SMMNGLGFNH IPESYNFQGS
GGGLSCPPNT LSLDSGIGMM NGHLAGNMDG MALSGHSMSH LSANGGHSYM GSCTGSTGSD
YPHHDNSASP LLTSGGVMEP HPVYSSSASA WAPAPSASLN NGASYIKQQP LSPCNPGANS
LQPSLPTHSL DQSYLHQNGH STDLQGIPRY HSQSPSMCDR KEFVFSFNAM TSSAMHSSSN
GSYYHHQQVS YQDIKPCVM
//
