ID A0A2I8VQ67_9EURY Unreviewed; 598 AA.
AC A0A2I8VQ67;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 18-JUN-2025, entry version 30.
DE RecName: Full=Probable translation initiation factor IF-2 {ECO:0000256|ARBA:ARBA00020166, ECO:0000256|HAMAP-Rule:MF_00100};
GN Name=infB {ECO:0000256|HAMAP-Rule:MF_00100};
GN ORFNames=C2R22_20480 {ECO:0000313|EMBL:AUV84080.1};
OS Salinigranum rubrum.
OC Archaea; Methanobacteriati; Methanobacteriota; Stenosarchaea group;
OC Halobacteria; Halobacteriales; Haloferacaceae; Salinigranum.
OX NCBI_TaxID=755307 {ECO:0000313|EMBL:AUV84080.1, ECO:0000313|Proteomes:UP000236584};
RN [1] {ECO:0000313|EMBL:AUV84080.1, ECO:0000313|Proteomes:UP000236584}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=GX10 {ECO:0000313|EMBL:AUV84080.1,
RC ECO:0000313|Proteomes:UP000236584};
RA Han S.;
RT "Complete genome sequence of Salinigranum rubrum GX10T, an extremely
RT halophilic archaeon isolated from a marine solar saltern.";
RL Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Function in general translation initiation by promoting the
CC binding of the formylmethionine-tRNA to ribosomes. Seems to function
CC along with eIF-2. {ECO:0000256|ARBA:ARBA00024852, ECO:0000256|HAMAP-
CC Rule:MF_00100, ECO:0000256|RuleBase:RU000644}.
CC -!- SIMILARITY: Belongs to the TRAFAC class translation factor GTPase
CC superfamily. Classic translation factor GTPase family. IF-2 subfamily.
CC {ECO:0000256|ARBA:ARBA00007733, ECO:0000256|HAMAP-Rule:MF_00100,
CC ECO:0000256|RuleBase:RU000644}.
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DR EMBL; CP026309; AUV84080.1; -; Genomic_DNA.
DR RefSeq; WP_103427769.1; NZ_CP026309.1.
DR AlphaFoldDB; A0A2I8VQ67; -.
DR GeneID; 35594522; -.
DR KEGG; srub:C2R22_20480; -.
DR OrthoDB; 30957at2157; -.
DR Proteomes; UP000236584; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:TreeGrafter.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR CDD; cd03703; aeIF5B_II; 1.
DR CDD; cd16266; IF2_aeIF5B_IV; 1.
DR CDD; cd01887; IF2_eIF5B; 1.
DR FunFam; 2.40.30.10:FF:000013; eukaryotic translation initiation factor 5B; 1.
DR FunFam; 3.40.50.300:FF:000112; Eukaryotic translation initiation factor 5B; 1.
DR FunFam; 3.40.50.10050:FF:000001; Translation initiation factor IF-2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 2.
DR Gene3D; 3.40.50.10050; Translation initiation factor IF- 2, domain 3; 1.
DR HAMAP; MF_00100_A; IF_2_A; 1.
DR InterPro; IPR004161; EFTu-like_2.
DR InterPro; IPR029459; EFTU-type.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005225; Small_GTP-bd.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR004544; TF_aIF-2_arc.
DR InterPro; IPR015760; TIF_IF2.
DR InterPro; IPR023115; TIF_IF2_dom3.
DR InterPro; IPR036925; TIF_IF2_dom3_sf.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR NCBIfam; TIGR00491; aIF-2; 1.
DR NCBIfam; NF003078; PRK04004.1; 1.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR43381:SF4; EUKARYOTIC TRANSLATION INITIATION FACTOR 5B; 1.
DR PANTHER; PTHR43381; TRANSLATION INITIATION FACTOR IF-2-RELATED; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF03144; GTP_EFTU_D2; 1.
DR Pfam; PF14578; GTP_EFTU_D4; 1.
DR Pfam; PF11987; IF-2; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR SUPFAM; SSF52156; Initiation factor IF2/eIF5b, domain 3; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR PROSITE; PS51722; G_TR_2; 1.
PE 3: Inferred from homology;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134, ECO:0000256|HAMAP-
KW Rule:MF_00100};
KW Initiation factor {ECO:0000256|ARBA:ARBA00022540, ECO:0000256|HAMAP-
KW Rule:MF_00100};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00100};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917, ECO:0000256|HAMAP-
KW Rule:MF_00100}; Reference proteome {ECO:0000313|Proteomes:UP000236584}.
FT DOMAIN 11..226
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
FT BINDING 20..27
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00100"
FT BINDING 82..86
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00100"
FT BINDING 136..139
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00100"
SQ SEQUENCE 598 AA; 65230 MW; F5DEDFBBCAA1EBBC CRC64;
MSESDTTPTA LRTPIVAVLG HVDHGKTSLL DTIRGSAVSE GEAGAITQHI GATAVPLETI
SDMAGSLVDP EDFDLPGLLF IDTPGHHSFS TLRSRGGALA DIAIVVVDVN DGFQPQTVEA
IEILKRTGTP FVVAANKIDT TPGWNPQEGA PIQQTYEAQS SRARSMLDEN LYEIIGDLSD
NGFSADLYWR VQNFQKNVGV VPSSAMTSEG IPDLLAVLMG LSQRYMKEEM QIDVTGPGAG
TVLEVKEERG FGTTLDVVLY DGSIKEGETI VVGGKNDPIV TEVRALLRPR PNAEIRTEKR
FERVDEVTAA SGVKIAAPDL EDAMAGAPVR VVRDRPVDEV IAEVKRELAE IEVETAEEGV
VVKADTLGSL EAMANALDEA EVPILRAEVG DVAPRDVAVA STANEEKHKV ILAFNVSVLK
NAQEELDKAG VKLFDDDVIY QLVEEYEAYV DEMQRAQQEN VLDKIIRPCR FRVLEDHVFR
QSNPAVVGVE VMSGTLKNNQ YVVKWEGNEP TRVGQLNGIQ EQGEDVSEAR AGKRVSVAID
GPTVGRQIDE GDELWIMLPE KHAKILEQEL SSDIPADELE ALQSYLDKHR RRDPFWGK
//
