ID A0A2J8KMR9_PANTR Unreviewed; 1530 AA.
AC A0A2J8KMR9; H2QZL7;
DT 25-APR-2018, integrated into UniProtKB/TrEMBL.
DT 25-APR-2018, sequence version 1.
DT 18-JUN-2025, entry version 39.
DE SubName: Full=Synaptonemal complex protein 2 {ECO:0000313|Ensembl:ENSPTRP00000039171.4};
GN Name=SYCP2 {ECO:0000313|Ensembl:ENSPTRP00000039171.4,
GN ECO:0000313|VGNC:VGNC:6277};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000039171.4, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000039171.4, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000039171.4}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2025) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|ARBA:ARBA00004286}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the SYCP2 family.
CC {ECO:0000256|ARBA:ARBA00007960}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AACZ04052929; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04052930; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_016793692.1; XM_016938203.1.
DR RefSeq; XP_016793693.1; XM_016938204.1.
DR RefSeq; XP_016793694.1; XM_016938205.1.
DR FunCoup; A0A2J8KMR9; 680.
DR STRING; 9598.ENSPTRP00000039171; -.
DR PaxDb; 9598-ENSPTRP00000039171; -.
DR Ensembl; ENSPTRT00000045404.4; ENSPTRP00000039171.4; ENSPTRG00000013687.6.
DR VGNC; VGNC:6277; SYCP2.
DR GeneTree; ENSGT00530000063859; -.
DR InParanoid; A0A2J8KMR9; -.
DR OMA; QWETVII; -.
DR TreeFam; TF332368; -.
DR Proteomes; UP000002277; Chromosome 20.
DR Bgee; ENSPTRG00000013687; Expressed in testis and 19 other cell types or tissues.
DR GO; GO:0000779; C:condensed chromosome, centromeric region; IBA:GO_Central.
DR GO; GO:0000800; C:lateral element; IBA:GO_Central.
DR GO; GO:0006915; P:apoptotic process; IEA:Ensembl.
DR GO; GO:0035234; P:ectopic germ cell programmed cell death; IEA:Ensembl.
DR GO; GO:0007143; P:female meiotic nuclear division; IEA:Ensembl.
DR GO; GO:0009566; P:fertilization; IEA:Ensembl.
DR GO; GO:0048808; P:male genitalia morphogenesis; IEA:Ensembl.
DR GO; GO:0007140; P:male meiotic nuclear division; IEA:Ensembl.
DR GO; GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl.
DR GO; GO:0051093; P:negative regulation of developmental process; IEA:Ensembl.
DR GO; GO:2000242; P:negative regulation of reproductive process; IEA:Ensembl.
DR InterPro; IPR024835; SYCP2-like.
DR InterPro; IPR041322; SYCP2_ARLD.
DR InterPro; IPR040560; SYCP2_SLD.
DR PANTHER; PTHR15607:SF12; SYNAPTONEMAL COMPLEX PROTEIN 2; 1.
DR PANTHER; PTHR15607; SYNAPTONEMAL COMPLEX PROTEIN-RELATED; 1.
DR Pfam; PF18581; SYCP2_ARLD; 1.
DR Pfam; PF18584; SYCP2_SLD; 1.
PE 3: Inferred from homology;
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277}.
FT DOMAIN 9..187
FT /note="Synaptonemal complex protein 2 armadillo-repeat-
FT like"
FT /evidence="ECO:0000259|Pfam:PF18581"
FT DOMAIN 278..389
FT /note="Synaptonemal complex protein 2 Spt16M-like"
FT /evidence="ECO:0000259|Pfam:PF18584"
FT REGION 439..480
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 498..558
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 653..676
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 692..717
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 756..775
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 962..1009
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 439..461
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 542..557
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 695..713
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 970..979
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 988..997
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1530 AA; 175877 MW; FE438BF00A9C3A27 CRC64;
MPIRPDLQQL EKCIDDALRK NDFKPLKTLL QIDICEDVKI KCSKQFFHKV DNLICRELNK
EDIHNVSAIL VSVGRCGKNI SVLGQAGLLT MIKQGLIQKM VAWFEKSKDI IQSQGNSKDE
AVLNMIEDLV DLLLVIHDVS DEGKKQVVES FVPRICSLVI DSRVNICIQQ EIIKRMNAML
DKMPQDARKI LSNQEMLILM SSMGERILDA GDYDLQVGIV EALCRMTTEK QRQELAHQWF
SMDFIAKAFK RIKDSEFETD CRIFLNLVNG MLGDKRRVFT FPCLSAFLDK YELQIPSDEK
LEEFWIDFNL GSQTLSFYIA GDNDDHQWEA VTVPEEKVQI YSIEVRESKK LLTIILKNTV
KISKREGKEL LLYFDASLEI TNVTQKIFGA NKHRESIRKQ GISVAKTSLH ILFDASGSQI
LVPESQISPV GEELVSLKEK SKSPKEFAKP SKYIKNSDKG NRNNSQLEKI TPSKRKMSEA
SMIVSGADRY TMRSPVLFSN TSIPPRRRRI KPPLQMMSSA EKPSVSQTSE NRVDNAASLK
SRSSEERHRR DNTDKHIKTA KCVENTENKN VEFPNQNFSE LQDVIPDSQP VEKRDHAILP
GVLDNICGNK IHSKWACWTP VTNIELCNNQ RASTSSGDTL NQDIVINKKL TKQKSSSSIS
DHNSEGTGKV KYKKEQTDHI KIDKAEVEVC KKHNQQQNHP KYSGQKNTEN AKQSDWPVES
ETTFKSVLLN KTIEESLIYK KKYILSKDVN TATCDKNPSA SKNVQSHRKA EKELTSELDS
WDLKQKKMRE KSKGKEFTDV AESLISQINK RYKTKDDIKS TRKLKESLIN SDFSNKPVVQ
LSKEKVQKKS YRKLKTTFVN VTSECPVNDV YNFNLNGADD PIIKLGIQEF QATAKEACAD
RSIRLVGPRN HDELKSSVKT KDKKIITNHQ KKNLFSDTET EYRCDDSKTD ISWLREPKSK
PQLIDYSRNK NVRNHKSGKS RSSLEKGQPS SKMTPSKNIM KKTDKTIPEG RIRLPRKATK
TKKNYKDLSN SESECEQEFS HSFKENIPVK EENIHSRMKT VKLPKKQQKV FCAETEKELS
KQCKNSSLLK DAIRDNCLDL SPRSLSGSPS SIEVTRCIEK ITEKDFTQDY DCITKSISPY
PKTSSLESLN SNSGVGGTIK SPKNNEKNFL CASESCSPIP RPLFLPRHTP TKSNTIVNRK
KKSSLVLTQE TQNCNSYSDV SSYSSEERFM EIESPHINEN YIQSKREESH LASSLSKSSE
GREKTWFDMP CDATHVSGPT QHLSRKRIYI EDNLSNSNEV EMEEKGERRA NLLPKKLCKI
EDADHHIHKM SESVSSLSTN DFSIPWETWR NEFAGIEMTY ETYERLNSEF KRRNNIRHKM
LSYFTTQSWK TAQQHLRTIN HQSQDSRIKK LDKFQFIIIE ELENFEKDSQ SLKDLEKEFV
DFWEKIFQKF SAYQKSEQQR LHLLKTSLAK SVFCNTDNEE TVFTSEMCLM KEDMKVLQDR
LLKDMLEEEL LNVRRELMSV FMSHERNANV
//
